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Involvement of oral tissues by AL amyloidosis: a literature review and report of eight new cases

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Abstract

Objective

Amyloidosis is a term used to describe a group of diseases in which there is an extracellular deposition of amorphous fibrillar proteins known as amyloid. The aim of this study was to present clinicopathological data from eight oral amyloidosis-affected patients and a deep review of the literature about the disease.

Materials and methods

A retrospective study was conducted based on the records of oral amyloidosis-affected patients diagnosed in our institution between 1978 and 2012. The clinicopathological features and immunohistochemical (IHC) staining with anti-kappa and anti-lambda light chain antibodies were carried out and analyzed.

Results

Eight patients were diagnosed with the disease; the tongue and women in their sixth decade of life were mostly affected. All lesions demonstrated apple-green birefringence and immunoreactivity for kappa-light chain, and four cases also showed lambda positivity. According to our series, four cases were diagnosed with localized amyloidosis and four with systemic amyloidosis. Prognosis for the systemic ones was gloomy, but good for the localized ones, which was characterized by a slow pattern of deposition without evolution to systemic involvement.

Conclusions

This study reinforces our knowledge about predilections, outcomes, and the importance of making a correct and quick diagnosis of oral amyloidosis and shows the necessity of more studies detailing oral amyloidosis predilection on a global scale. The importance and utility of IHC in the typing of the biochemical nature of amyloid deposits are becoming increasingly necessary for proper management of the patient. Correct classification of the type of amyloid is important for treatment consequences.

Clinical relevance

This article highlights the clinicopathological data of patients with amyloidosis affecting oral tissues and compare these new findings with other worldwide descriptions. Because of its rarity, such data are often unfamiliar to most clinicians and pathologists.

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Acknowledgments

Fundação de Amparo a Pesquisa do Estado de Minas Gerais–FAPEMIG, and Conselho Nacional de Desenvolvimento Científico e Tecnológico–CNPq.

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Authors and Affiliations

  1. Universidade Federal de Uberlandia, Uberlandia, Minas Gerais, Brazil

    Flávia Sayuri Matsuo, Luiz Fernando Barbosa de Paulo, João Paulo Silva Servato, Paulo Rogério de Faria, Sergio Vitorino Cardoso & Adriano Mota Loyola

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  1. Flávia Sayuri Matsuo
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  2. Luiz Fernando Barbosa de Paulo
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  3. João Paulo Silva Servato
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  4. Paulo Rogério de Faria
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  5. Sergio Vitorino Cardoso
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  6. Adriano Mota Loyola
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Corresponding author

Correspondence to Adriano Mota Loyola.

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The authors declare that they have no competing interests.

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Matsuo, F.S., Barbosa de Paulo, L.F., Servato, J.P.S. et al. Involvement of oral tissues by AL amyloidosis: a literature review and report of eight new cases. Clin Oral Invest 20, 1913–1920 (2016). https://doi.org/10.1007/s00784-015-1649-3

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  • DOI: https://doi.org/10.1007/s00784-015-1649-3

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