Abstract
Polyketide cyclase from Mycobacterium tuberculosis (MtPC) is related to the formation of sterol derivatives, which may play a role in immune escape in the initial stage of macrophage infection by Mycobacterium tuberculosis. However, the structure and specific functions of MtPC are still unknown. Here we report the backbone and side-chain NMR resonance assignments for the MtPC. Most resonances were assigned and the secondary structure was predicted according to the assigned backbone resonances by TALOS-N and PECAN. These NMR assignments represent a first step towards researching the structure and function of MtPC.
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Acknowledgements
This work was supported by the National Key Research and Development Project of China (No. 2016YFA0500600). All the NMR experiments were performed at the High‐Field Nuclear Magnetic Resonance Centre of Xiamen University
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Fan, S., Zhuang, J., Guo, C. et al. 1H, 13C, 15N backbone and side-chain chemical shift assignments of the polyketide cyclase from Mycobacterium tuberculosis. Biomol NMR Assign 15, 397–402 (2021). https://doi.org/10.1007/s12104-021-10036-5
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DOI: https://doi.org/10.1007/s12104-021-10036-5