To the Editor: Elizabethkingia species are saprophytic gram-negative rods ubiquitous in soil and water but can occasionally cause sepsis and meningitis in infants [1]. These bacteria can colonize water sinks and respirators, and contaminate saline solutions, lipid solutions, and reconstituted antibiotics [2, 3]. Clinical reports from neonatal intensive care units (NICUs) are few [4]. In two outbreaks in our NICU, we noticed that this bacterium frequently infected neonates without the usual risk factors for nosocomial infection like intravenous catheters or ventilator support and had a high propensity to cause meningitis. The number of affected neonates were 2 and 30 in the two outbreaks, respectively. A total of 47 isolates of Elizabethkingia species were identified from the blood and cerebrospinal fluid (CSF) of the 32 neonates (36 blood and 11 nonaugmented CSF cultures). Nine infants had growth in both blood and CSF. We noted meningitis, requirement of ventriculo-peritoneal shunt placement, and mortality in 19, 4, and 6 infants, respectively. Isolation of the organism was done by using BacT/ALERT, and VITEK-2 system was used for species identification and for antibiotic sensitivity pattern. The mean time to positivity for growth from blood was 12.9 (range 2–23) h. E. anophelis was isolated in half the cases and E. meningoseptica in the rest. Susceptibility to amikacin, ciprofloxacin, cefoperazone-sulbactam, and piperacillin-tazobactam was noted in 68%, 72%, 72%, and 30%, respectively. We noted universal resistance to carbapenems (intrinsic resistance) and universal sensitivity to levofloxacin and minocycline. Line-listing of the cases helped to narrow down the source in the first outbreak. Extensive environmental microbiological investigations resulted in isolation of E. meningoseptica from one of the breast pumps. Cleaning protocols for reusable accessories were changed and reinforced, including cleaning of the tubing and container and capping of the tubing after use. However, the source of infection could not be identified in the second outbreak, despite repeated extensive environmental testing.