Skip to main content

Advertisement

Log in

Retinopathy of Prematurity

  • Symposium on AIIMS Protocols in Neonatology
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Retinopathy of prematurity (ROP) occurs due to abnormal proliferation of retinal vessels. The most important risk factors which predispose to development of ROP include oxygen therapy, anemia needing blood transfusion, sepsis and apnea. Very low birth weight neonates, those born at ≤32 week of gestation and other preterm neonates with risk factors must be screened for ROP. As a general rule first screening should be done at 1 month of postnatal age. If screening detects ROP not needing treatment follow up should be planned according to location and stage of ROP. Better visual outcomes are observed with earlier treatment at lower threshold. Peripheral retinal ablation with diode laser under adequate analgesia and sedation is the preferred method for treatment of severe ROP. Guidelines regarding the procedure of dilatation, ophthalmic examination and treatment (if required) have been provided in the protocol. Close co-operation between the ophthalmologist and neonatologist is essential for successful management of ROP.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Flynn JT. The premature retina: a model for the in vivo study of molecular genetics? Eye. 1992;6:161–5.

    Article  PubMed  Google Scholar 

  2. Kushner BJ, Essner D, Cohen IJ, Flynn JT. Retrolental fibroplasia II. Pathologic correlation. Arch Ophthalmol. 1977;95:29–38.

    Article  PubMed  CAS  Google Scholar 

  3. Chan-Ling T, Tout S, Hollander H, Stone J. Vascular changes and their mechanisms in the feline model of retinopathy of prematurity. Invest Ophthalmol Vis Sci. 1992;33:2128–47.

    PubMed  CAS  Google Scholar 

  4. Chan-Ling T, Gock B, Stone J. The effect of oxygen on vasoformative cell division. Evidence that ‘physiological hypoxia’ is the stimulus for normal retinal vasculogenesis. Invest Ophthalmol Vis Sci. 1995;36:1201–14.

    PubMed  CAS  Google Scholar 

  5. Chaudhari S, Patwardhan V, Vaidya U, Kadam S, Kamat A. Retinopathy of prematurity in a tertiary care center—incidence, risk factors and outcome. Indian Pediatr. 2009;46:219–24.

    PubMed  Google Scholar 

  6. Charan R, Dogra MR, Gupta A, Narang A. The incidence of retinopathy of prematurity in a neonatal care unit. Indian J Ophthalmol. 1995;43:123–6.

    PubMed  CAS  Google Scholar 

  7. Gupta VP, Dhaliwal U, Sharma R, Gupta P, Rohatgi J. Retinopathy of prematurity—risk factors. Indian J Pediatr. 2004;71:887–92.

    Article  PubMed  Google Scholar 

  8. Maheshwari R, Kumar H, Paul VK, Singh M, Deorari AK, Tiwari HK. Incidence and risk factors of retinopathy of prematurity in a tertiary care newborn unit in New Delhi. Natl Med J India. 1996;9:211–4.

    PubMed  CAS  Google Scholar 

  9. Aggarwal R, Deorari AK, Azad RV, et al. Changing profile of retinopathy of prematurity. J Trop Pediatr. 2002;48:239–42.

    Article  PubMed  Google Scholar 

  10. Dutta S, Narang S, Narang A, Dogra M, Gupta A. Risk factors of threshold retinopathy of prematurity. Indian Pediatr. 2004;41:665–71.

    PubMed  Google Scholar 

  11. Rekha S, Battu RR. Retinopathy of prematurity: incidence and risk factors. Indian Pediatr. 1996;33:999–1003.

    PubMed  CAS  Google Scholar 

  12. Gopal L, Sharma T, Ramachandran S, Shanmugasundaram R, Asha V. Retinopathy of prematurity: a study. Indian J Ophthalmol. 1995;43:59–61.

    PubMed  CAS  Google Scholar 

  13. Varughese S, Jain S, Gupta N, Singh S, Tyagi V, Puliyel JM. Magnitude of the problem of retinopathy of prematurity. experience in a large maternity unit with a medium size level-3 nursery. Indian J Ophthalmol. 2001;49:187–8.

    PubMed  CAS  Google Scholar 

  14. Sharma P. DM dissertation: Risk factors for severe retinopathy of prematurity in preterm low birth weight neonates Department of Pediatrics. New Delhi: All India Institute of Medical Sciences 2009 (Submitted for publication to Indian Journal of Pediatrics).

  15. Saunders RA, Donahue ML, Christmann LM, et al. Racial variation in retinopathy of prematurity. The cryotherapy for retinopathy of prematurity cooperative group. Arch Ophthalmol. 1997;115:604–8.

    Article  PubMed  CAS  Google Scholar 

  16. Hellstrom A, Hard AL, Engstrom E, et al. Early weight gain predicts retinopathy in preterm infants: new, simple, efficient approach to screening. Pediatrics. 2009;123:e638–45.

    Article  PubMed  Google Scholar 

  17. Hellstrom A, Ley D, Hansen-Pupp I, et al. New insights into the development of retinopathy of prematurity—importance of early weight gain. Acta Paediatr 2010;99:502–8.

    Google Scholar 

  18. The International Classification of Retinopathy of Prematurity revisited. Arch Ophthalmol. 2005;123:991–99.

    Google Scholar 

  19. Azad R, Chandra P, Patwardhan SD, Gupta A. Importance of the ‘third criterion’ for retinopathy of prematurity screening in developing countries. J Pediatr Ophthalmol Strabismus. 2009;46:332–4.

    Article  PubMed  Google Scholar 

  20. Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2006;117:572–576.

  21. Sun X, Lemyre B, Barrowman N, O’Connor M. Pain management during eye examinations for retinopathy of prematurity in preterm infants: a systematic review. Acta Paediatr. 2010;99:329–34.

    Article  PubMed  CAS  Google Scholar 

  22. Kemper AR, Wallace DK, Quinn GE. Systematic review of digital imaging screening strategies for retinopathy of prematurity. Pediatrics. 2008;122:825–30.

    Article  PubMed  Google Scholar 

  23. Early Treatment For Retinopathy Of Prematurity Cooperative Group. Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol. 2003;121:1684–94.

    Article  PubMed  CAS  Google Scholar 

  24. Finer N, Leone T. Oxygen saturation monitoring for the preterm infant: the evidence basis for current practice. Pediatr Res. 2009;65:375–80.

    Article  PubMed  Google Scholar 

  25. Flynn JT, Bancalari E, Snyder ES, et al. A cohort study of transcutaneous oxygen tension and the incidence and severity of retinopathy of prematurity. N Engl J Med. 1992;326:1050–4.

    Article  PubMed  CAS  Google Scholar 

  26. Castillo A, Sola A, Baquero H, et al. Pulse oxygen saturation levels and arterial oxygen tension values in newborns receiving oxygen therapy in the neonatal intensive care unit: is 85% to 93% an acceptable range? Pediatrics. 2008;121:882–9.

    Article  PubMed  Google Scholar 

  27. Tin W, Milligan DW, Pennefather P, Hey E. Pulse oximetry, severe retinopathy, and outcome at one year in babies of less than 28 weeks gestation. Arch Dis Child Fetal Neonatal Ed. 2001;84:F106–10.

    Article  PubMed  CAS  Google Scholar 

  28. Chow LC, Wright KW, Sola A. Can changes in clinical practice decrease the incidence of severe retinopathy of prematurity in very low birth weight infants? Pediatrics. 2003;111:339–45.

    Article  PubMed  Google Scholar 

  29. Askie LM, Henderson-Smart DJ, Irwig L, Simpson JM. Oxygen-saturation targets and outcomes in extremely preterm infants. N Engl J Med. 2003;349:959–67.

    Article  PubMed  CAS  Google Scholar 

  30. Supplemental Therapeutic Oxygen for Prethreshold Retinopathy Of Prematurity (STOP-ROP), a randomized, controlled trial. I: primary outcomes. Pediatrics. 2000;105:295–310.

    Google Scholar 

  31. Brion LP, Bell EF, Raghuveer TS. Vitamin E supplementation for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2003:CD003665.

  32. Micieli JA, Surkont M, Smith AF. A systematic analysis of the off-label use of bevacizumab for severe retinopathy of prematurity. Am J Ophthalmol. 2009;148:536–43. e532.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ashok Deorari.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chawla, D., Agarwal, R., Deorari, A. et al. Retinopathy of Prematurity. Indian J Pediatr 79, 501–509 (2012). https://doi.org/10.1007/s12098-010-0279-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12098-010-0279-7

Keywords

Navigation