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Retinopathy of prematurity — Risk factors

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Abstract

Objective: Improved survival of low birth weight, premature babies have increased the incidence of retinopathy of prematurity. This hospital-based, prospective, study was undertaken to determine its incidence and risk factors in our neonatal unit.Methods: Neonates with gestational age ≤ 35 weeks and/or birth weight ≤ 1500 gm born over a one-year period were examined by indirect ophthalmoscopy between 2 to 4 weeks after birth, and followed up till retinal vascularisation was complete. Maternal and neonatal risk factors were noted and data analyzed by statistical package SPSS-10.0.Results: Sixty babies were thus examined. The incidence of retinopathy was 21.7% in the cohort, 33.3% in babies ≤32 weeks gestation and 36.4% in babies weighing ≤1250 gm. Oxygen (p=0.01), sepsis (p=0.04) and apnoea (p=0.02) were independent risk factors. Retinopathy was significantly more severe in babies with hyaline membrane disease (p=0.02) and lower birth weight (p=0.02). Severe disease was never seen before 6.5 weeks of age.Conclusion: Indirect ophthalmoscopy should be performed at 4 weeks of post natal age in all preterm babies with birth weight ≤ 1500 gm, and intensified in the presence of risk factors like oxygen administration, apnoea and septicemia.

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References

  1. Charles JB, Ganthier R Jr, Appiah AP. Incidence and characteristics of retinopathy of prematurity in a low-income inner-city population.Ophthalmology 1991; 98(1): 14–17.

    PubMed  CAS  Google Scholar 

  2. Charan R, Dogra MR, Gupta A, Narang A. The incidence of retinopathy of prematurity in a neonatal care unit.Indian J Ophtholmol 1995; 43:123–126.

    CAS  Google Scholar 

  3. Gopal L, Sharma T, Ramachandran S, Shanmugasundaram R, Asha V. Retinopathy of prematurity: a study.Indian J Ophthalmol 1995; 43:59–61.

    PubMed  CAS  Google Scholar 

  4. Maheshwari R, Kumar H, Paul VK, Singh M, Deorari AK, Tiwari AK. Incidence and risk factors of retinopathy of prematurity in a tertiary care newborn unit in New Delhi.Natl Med J Ind 1996; 9(5): 211–214.

    Google Scholar 

  5. Rekha S, Battu RR. Retinopathy of prematurity: incidence and risk factors.Indian Pediatrics 1996; 33:999–1003.

    Google Scholar 

  6. Aggarwal R, Deorari AK, Azad RVet al. Changing profile of retinopathy of prematurity.J Trop Pediatr 2002; 48(4): 239–242.

    Article  PubMed  Google Scholar 

  7. Schalij-Delfos NE, Ziljmans BLM, Wittebol-Post D, Tan KEWP, Cats BP. Screening for retinopathy of prematurity. Do former guidelines still apply?J Pediatr Ophthalmol Strabismus 1996; 33:35–38.

    Google Scholar 

  8. Cotton RB, Oisson T, Law AB. The physiological effects of surfactant treatment on gas exchange in newborn premature infants with hyaline membrane disease.Pediatr Res 1993; 34: 495–501.

    Article  PubMed  CAS  Google Scholar 

  9. Brown DR, Milley JR, Ripepi UJ, Biglan AW. Retinopathy of prematurity. Risk factors in a five-year cohort of critically ill premature neonates.AJDC 1987; 141:154–160.

    PubMed  CAS  Google Scholar 

  10. Holmstrom G, Thomassen P, Broberger U. Maternal risk factors for retinopathy of prematurity- a population-based study.Acta Obstet Gynecol Scand 1996; 75(7): 628–635.

    Article  Google Scholar 

  11. Committee for the classification of retinopathy of prematurity. An international classification of retinopathy of prematurity.Arch Ophthalmol 1984; 102:1130–1134.

    Google Scholar 

  12. Committee for the classification of retinopathy of prematurity. An international classification of retinopathy of prematurity, II: the classification of retinal detachment.Arch Ophthalmol 1987; 105:906–912.

    Google Scholar 

  13. Gilbert C, Foster A. Childhood blindness in the context of Vision 2020- the right to sight.Bull WHO 2001; 79:227–232.

    PubMed  CAS  Google Scholar 

  14. Varughese S, Jain S, Gupta N, Singh S, Tyagi V, Puliyel JM. Magnitude of the problem of retinopathy of prematurity. Experience in a large maternity unit with a medium size level- 3 nursery.Indian J Ophthalmol 2001; 49:187–188.

    PubMed  CAS  Google Scholar 

  15. Darwani S, Parwani S, Jain S. Fundus examination for retinopathy of prematurity.Indian Pediatr 1996; 33:250–252.

    Google Scholar 

  16. Patil J, Deodhar J, Wagh S, Pandit AN. High risk factors for development of retinopathy of prematurity.Indian Pediatr 1997; 34:1024–1027.

    PubMed  CAS  Google Scholar 

  17. Fledelius HC, Dahl H. retinopathy of prematurity, a decrease in frequency and severity. Trends over 16 years in a Danish county.Acta Ophthalmol Scand 2000; 78:359–361.

    Article  PubMed  CAS  Google Scholar 

  18. Leo SW, Cheong PYY. Incidence of retinopathy of prematurity in Singapore.Singapore Med J 1997; 38:54–57.

    PubMed  CAS  Google Scholar 

  19. Bullard SR, Donahue SP, Feman SS, Sinatra RB, Walsh FW. The decreasing incidence and severity of retinopathy of prematurity.J AAPOS 1999; 3:46–52.

    Article  PubMed  CAS  Google Scholar 

  20. Chye JK, Lim CT, Leong HL, Wong PK. Retinopathy of prematurity in very low birth weight infants.Ann Acad Med Singapore 1999; 28(2): 193–198.

    PubMed  CAS  Google Scholar 

  21. Al Essa M, Azad SV, Rashwan N. Rate of and risk factors associated with retinopathy of prematurity: a prospective study from Kuwait.Med Principles Practice 1999; 8(2): 115–118.

    Article  Google Scholar 

  22. Hussain N, Clive J, Bhandari V. Current incidence of retinopathy of prematurity. 1989–1997.Pediatrics 1999; 104(3): e26.

    Article  PubMed  CAS  Google Scholar 

  23. Blair BM, O;halloran HS, Pauly TH, Stevens JL. Decreased incidence of retinopathy of prematurity. 1995–1997.J AAPOS 2001; 5(2): 118–122.

    PubMed  CAS  Google Scholar 

  24. Nair PM, Ganesh A, Mitra S, Ganguly SS. Retinopathy of prematurity in VLBW and extreme LBW babies.Indian J Pediatr 2003; 70(4): 303–306.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, University College of Medical Sciences and GTB Hospital, Delhi, India

    Piyush Gupta

  2. Department of Ophthalmology, University College of Medical Sciences and GTB Hospital, Delhi, India

    Ved P. Gupta, Upreet Dhaliwal, Rohit Sharma, Piyush Gupta & Jolly Rohatgi

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  1. Ved P. Gupta
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  2. Upreet Dhaliwal
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  3. Rohit Sharma
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  4. Piyush Gupta
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Correspondence to Upreet Dhaliwal.

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Gupta, V.P., Dhaliwal, U., Sharma, R. et al. Retinopathy of prematurity — Risk factors. Indian J Pediatr 71, 887–892 (2004). https://doi.org/10.1007/BF02830827

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