Abstract
Ten children aged 11 months to 10 years (means 5.7 years) with reflux nephropathy, vesicoureteric reflux (VUR) and normal or mildly impaired renal function having GFR more than 50 ml/min/1.72 m2, were included in the study. The hematological and biochemical parameters were within normal limits. Height standard deviation score (HZ score) was reduced at entry and, decreased further during follow-up (−2.2 and −2.6 at 0 and 12 months, respectively). Weight for height index (WHI) improved significantly (p=0.0004) during follow-up. The basal and stimulated peak growth hormone levels of these patients were found to be elevated, 18.53 ± 11.36 μg/L and 34.20 ± 5.86 μg/L, respectively. The IGF-1 levels were low ranging from 45.00 to 84.40 ng/dl (mean ± SD 61.54 ± 10.21 ng/dl) compared to 51.80 to 247.50 ng/dl (mean ± SD111.20 ± 70.24 ng/dl) in age and sex matched controls, indicating partial insensitivity to growth hormone.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Polito C, La Manna A, Capacchione A, Pullano F, Lovene A, Del Gado R. Height and weight in children with vesicoureteric efflux and renal scarring. Pediatr Nephrol 1996; 10: 564–756.
Polito C, Marte A, Zamparelli M, Papale MR, Racco CE, La Manna A. Catch-up growth in children with vesico-ureteric reflux. Pediatr Nephrol 1997; 11: 164–168.
Report of International Reflux Study Committee. Medical versus surgical reatment of primary vesicoureteral reflux. Prospective international reflux study in children. J Urol 1981; 125: 277–283.
Tanner JM, Whitehouse RH, Marshall WA, Healy MJR, Goldstein H. Assessment of skeletal maturity and prediction of adult height (TW2 method) 2nd ed. Styne DM Puberty and its disorder vol II. London; Academic Press; 1983; 1–106.
Menon PSN, Gupta P, Karmarkar MG. High and low dose clonidine tests for the diagnosis of growth hormone deficiency. Indian Pediatr 1994; 31: 145–150.
Merell RW, Moward JJ. Increased physical growth after successful antireflux operation. J Urol 1979; 12: 523–527.
Chertin B, Farkas A, Puri P. Insulin-like growth factor-1 expression in reflux nephropathy. Pediatr Surg Int 2004; 20: 283–289.
Marc R, Ammerman, Miller BS. The growth hormone insulin like growth factor axis in kidney revisited. Am J Physiol 1993; 265: F1–F4.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Das, S.K., Menon, P.S.N., Bagga, A. et al. Physical growth in children with reflux nephropathy with normal or mildly impaired renal function. Indian J Pediatr 77, 684–686 (2010). https://doi.org/10.1007/s12098-010-0077-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12098-010-0077-2