Abstract
Anti-platelet drugs have been used to prevent thrombosis of systemic to pulmonary artery shunts. Aspirin has traditionally been used. Clopidogrel is being studied as an alternative and in combination with aspirin for shunt patients. We report a near fatal gastro-intestinal bleed in a patient with shunt and on aspirin and clopidogrel. This combination has been known to produce similar bleeds. The authors recommend caution in combining them. Prospective studies currently underway should evaluate this aspect of the antiplatelet drugs.
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References
Li JS, Berezny KY, Yow E, Bokesch PM et al. Optimal Dose of Clopidogrel for Platelet Inhibition in Children: Primary Results of the PICOLO Trial [Abstr]. Circulation 2006; 114:II–450.
Efficacy and safety of Clopidogrel in neonates/infants with systemic to pulmonary artery shunt palliation (CLARINET). Available at: http://clinicaltrials.gov/ct/gui/show/NCT00396877. Accessed September 12, 2007.
Derry S, Loke YK. Risk of gastrointestinal hemorrhage with long term use of aspirin: meta-analysis. BMJ 2000; 321:1183–1187.
Chan FKL, Ching JYL, Hung LCT et al. Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. N Engl J Med 2005;352:238–244.
Finkelstein Y, Nurmohamed L, Avner M, Benson LN, Koren G. Clopidogrel use in children. J Pediatr 2005; 147:657–661.
Soman T, Rafay MF, Hune S, Allen A, MacGregor D, deVeber G. The risks and safety of clopidogrel in pediatric arterial ischemic stroke. Stroke 2006; 37: 1120–1122.
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Kohli, V., Sibal, A., Choudhary, S. et al. Gastrointentinal bleed with clopidogrel and aspirin. Indian J Pediatr 77, 101–102 (2010). https://doi.org/10.1007/s12098-009-0264-1
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DOI: https://doi.org/10.1007/s12098-009-0264-1