Skip to main content

Advertisement

SpringerLink
Log in

Clinico-etiological and EEG profile of neonatal seizures

  • Original Article
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Objective

To evaluate clinical, etiological and EEG profile of neonatal seizures.

Methods

In all the neonates enrolled in the study baseline information recorded was sex, gestational age, weight, ponderal index etc. Clinical profile of seizure episode included age at onset of seizure, type and duration of seizure, associated autonomic changes, medication given, response time to medication and possible cause. Relevant maternal history including antenatal and peripartum history was recorded. Relevant history and examination of newborn were noted. Essential investigations done in all subjects included blood glucose, serum calcium, serum sodium and arterial pH. USG cranium and EEG were done at earliest in all the subjects wherever feasible. Additional investigations were done as guided by history, physical examination and essential investigations.

Results

Ninety babies with clinical seizures were enrolled into the study over one year period with an overall incidence of 1.17% (0.69% in term babies and 6.14% in preterm babies). Abnormal EEG’s were found in one third cases out of 60 EEG’s done in 90 babies. 26.7% of babies with perinatal asphyxia had abnormal EEG’s (8/30). While 60% of babies with HIE II had abnormal discharges, background activity was suppressed in 66.66% EEG’s in babies with HIE III.

Conclusions

Overall incidence of neonatal seizures was 11.7/1000 live births, majority being preterm very low birth weight babies before 5 days of life. Perinatal asphyxia was responsible in 44.44% babies followed by metabolic abnormalities (23.33%). EEG abnormalities were present in 33.34% babies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Volpes J. Neonatal seizures. N Engl J Med 1973; 289: 164–168.

    Google Scholar 

  2. Kuppuswami Scale for Scoio-economic status in urban area (1994). Source: Kuppuswami B. Manual of Socio-economic status Scale (URBAN) Manasayan, 32, Netaji Subhash Nagar, Delhi-110006.

    Google Scholar 

  3. Manmohan, Shivprasad SR, Chellani HK, Kapni V. Intrauterine Growth curves in North Indian babies: weight, length, head circumference and ponderal index. Indian Pediatr 1990; 27: 43–51.

    Google Scholar 

  4. American EEG Society. Guidelines in EEG, 1–7. Report of the American EEG Society Ad Hoc Committee on Techniques. 1985.

  5. Rennie JM, Bylan GB. Neonatal seizures. In David TJ, ed. Recent Advances in Paediatrics 18. Churchill Livingstone, Edinburgh 2002; pp. 19–32.

    Google Scholar 

  6. Laroia N. Current Controversies in Diagnosis and Management of Neonatal Seizures. Indian Pediatr 2000; 37: 367–372.

    PubMed  CAS  Google Scholar 

  7. Bernes SM, Kaplan AM. Evolution of neonatal seizures. Ped Clin North Am 1994; 41(5): 1069–1104.

    CAS  Google Scholar 

  8. Rennie JM. Neonatal seizures. Eur J Pediatrics 1997; 156: 83–87.

    Article  CAS  Google Scholar 

  9. Lanska MJ, Lanska DJ, Baumann RJ, Kryscio RJ. A populations based study of neonatal seizures in Fayette county, Kentucky. Neurology 1995; 45: 724–732.

    PubMed  CAS  Google Scholar 

  10. Mizrahi EM, Kellaway P. Characterization and Classification of neonatal seizures. Neurology 1987; 37: 1837–1844.

    PubMed  CAS  Google Scholar 

  11. Scher MS, Aso K, Beggarly ME, Hamid MY, Steppe DA, Painter MJ. Electrographic Seizures in Preterm and Full-term Neonates: Clinical Correlates, Associated Brain Lesions and Risk for Neurologic Sequelae. Pediatrics 1993; 91(1): 128–134.

    PubMed  CAS  Google Scholar 

  12. Levene MI, Trounce JQ. Causes of Neonatal Convulsions. Arch Dis Child 1986; 61: 78–79.

    PubMed  CAS  Google Scholar 

  13. Goldberg HJ. Neonatal convulsions — a ten year review. Arch Dis Child 1983; 57: 633–635.

    Google Scholar 

  14. Rajadhyaksha S, Shah KN, Jadhav VM. Electroencephalogram in a Neonate. Jour Neonatol 2000; 14(2): 35–39.

    Google Scholar 

  15. Rose AL, Lombroso CT. Neonatal seizure status: A Study of Clinical, Pathological and Electroencephalographic features in 137 Full Term Babies with a Long Term Follow Up. Pediatrics 1970; 45: 404–425.

    PubMed  CAS  Google Scholar 

  16. Naveen B, Vanitha AJ, Vijai Kumar HV, Gururaj S, Satish, Rajashekhar. Etiological Profile of Neonatal Seizures in a Referral Centre. Abstract of scientific paper presented at 20th Annual convention of NNF. at Mumbai, Nov 2000.

  17. Volpe JJ. Neonatal seizures. In: volpe JJ. Neurology of Newborn 4th Ed. W.B. Saunders, Philadelphia 2001;pp178–214.

    Google Scholar 

  18. Bergman I, Painter MJ, Hirsch RP et al. Outcome in Neonates with Convulsions treated in ICU. Ann Neurol 1983; 14: 642–647.

    Article  PubMed  CAS  Google Scholar 

  19. Westerlaine CGN and Vert P (eds.). Analysis of neonatal seizures In: Westerline CGN and Vert P. Neonatal seizures. Raven Press, New York 1990;pp 1–9.

  20. Keen JH, Lee D. Sequelae of Neonatal Convulsions: A Study of 112 Infants. Arch Dis Child 1973; 48: 542–546.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, 110002, India

    Ajay Kumar (Professor of Pediatrics), Ashish Gupta & Bibek Talukdar

Authors
  1. Ajay Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ashish Gupta
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bibek Talukdar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ajay Kumar.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kumar, A., Gupta, A. & Talukdar, B. Clinico-etiological and EEG profile of neonatal seizures. Indian J Pediatr 74, 33–37 (2007). https://doi.org/10.1007/s12098-007-0023-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12098-007-0023-0

Key words

Search

Navigation