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Diagnosis of SPECT/CT bone imaging combined with two serum examinations in patients with bone metastases from pulmonary cancer

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Abstract

Purpose

To study the clinical diagnostic value of SPECT/CT bone imaging combined with two serum examinations in patients with bone metastases from pulmonary cancer.

Methods

The clinical data of 120 patients consistent with pulmonary cancer admitted to the First Affiliated Hospital of Hebei North University from March 2019 to December 2019 were selected for retrospective analysis, and they were divided into the bone metastasis group (n = 58) and non-bone metastasis group (n = 62) according to comprehensive evaluation result of X-ray, CT, MRI and clinical follow-up. The CT values of patients were obtained by SPECT/CT bone imaging to compare serum levels of ALP (alkaline phosphatase belongs to phosphoric monoester hydrolases, as a specific phosphatase, mainly in body tissues and body fluid) and BAP (bone alkaline phosphatase is formed by different modification and processing of alkaline phosphatase, and is mainly released by osteoblasts) and CT values of patients in both groups, using receiver operating characteristic (ROC) curve to evaluate the diagnostic efficacy of single detection and combined detection.

Results

SPECT/CT bone imaging in patients with bone metastasis from pulmonary cancer showed abnormal radioactive accumulation in spine, pelvis and bilateral ribs. Serum ALP, BAP and CT values in bone metastasis group were overtly higher than the non-bone metastasis group (P < 0.001). Logistic regression analysis showed that serum ALP, BAP and CT value were independent risk factors for bone metastasis from pulmonary cancer. The AUC value and Youden index of combined diagnosis were higher than those of single diagnosis.

Conclusion

SPECT/CT bone imaging combined with serum detection of ALP and BAP in patients with pulmonary cancer is helpful for early diagnosis of bone metastasis, which provides more basis for the formulation and selection of clinical treatment options.

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Data Availability

Data to support the findings of this study is available on reasonable request from the corresponding author.

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Funding

This research was funded by Diagnostic value of SPECT/CT bone imaging in bone metastasis of lung cancer, grant number 1921026D.

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Authors and Affiliations

  1. Department of Nuclear Medicine, The First Affiliated Hospital of Hebei North University, No. 12, Changqing Road, Qiaoxi District, Zhangjiakou, 075000, Hebei, China

    Yi Zhou, Chuangui Li, Shasha Jiang, Faliang Niu, Feng Cui, Hongwei Ma & Yan Li

  2. Department of Medical Imaging, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, Hebei, China

    Yusen Zhao

  3. Department of Thoracic Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, Hebei, China

    Dong Wei

Authors
  1. Yi Zhou
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  2. Chuangui Li
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  3. Shasha Jiang
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  4. Faliang Niu
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  5. Feng Cui
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  7. Dong Wei
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  8. Hongwei Ma
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  9. Yan Li
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Contributions

YZ conceived and designed the study, and drafted the manuscript. CL, SJ, FN, FC and YZ collected, analyzed and interpreted the experimental data. DW, HM and YL revised the manuscript for important intellectual content. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yi Zhou.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was approved by Ethical Committee of The First Affiliated Hospital of Hebei North University and conducted in accordance with the ethical standards.

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Subjects signed the informed consent.

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Zhou, Y., Li, C., Jiang, S. et al. Diagnosis of SPECT/CT bone imaging combined with two serum examinations in patients with bone metastases from pulmonary cancer. Clin Transl Oncol 26, 147–154 (2024). https://doi.org/10.1007/s12094-023-03231-4

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  • DOI: https://doi.org/10.1007/s12094-023-03231-4

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