Abstract
Purpose
Treatment of recurrent ovarian carcinoma is a challenge, particularly for the clear cell (CCC) subtype. However, there is a preclinical rationale that these patients could achieve a benefit from antiangiogenic therapy. To assess this hypothesis, we used the growth modulation index (GMI), which represents an intrapatient comparison of two successive progression-free survival (PFS).
Methods
We conducted a retrospective real-world study performed on 34 patients with recurrent ovarian cancer, treated with bevacizumab-containing regimens from January 2009 to December 2017. The primary endpoint was GMI. An established cut-off > 1.33 was defined as a sign of drug activity.
Results
73.5% of patients had high-grade serous ovarian carcinoma (HGSOC), and 17.7% had CCC; 70.6% of patients received carboplatin/gemcitabine/bevacizumab, and 29.4% received weekly paclitaxel/bevacizumab. According to histological subtype, the overall response rate and median PFS were 52% and 14 months for HGSOC and 83.3% and 20 months for CCC, respectively. The overall population median GMI was 0.99; it was 0.95 and 2.36 for HGSOC and CCC, respectively. CCC subtype was significantly correlated with GMI > 1.33 (odds ratio 41.67; 95% confidence interval 3.6–486.94; p = .03).
Conclusion
Adding bevacizumab to chemotherapy in recurrent CCC is associated with a remarkable benefit in this cohort. The efficacy of antiangiogenic drugs in CCC warrants further prospective evaluation.
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We will provide our data for the reproducibility of this study in other centers if such is requested.
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Conceptualization: AR, AG, JR-P, JB; data collection: JB, AG, JR-P; data analysis: JR-P, JB, AG; writing—original draft preparation: AG, JR-P, AR; writing—review and editing: MM, AB, GC, BC, EE, AH, DH, JF, AR; supervision: AR.
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AG reports honoraria and advisory/consultancy (Pharmamar), travel/accommodation/expenses (Roche, Tesaro-GSK, Pierre-Fabre, Pharmamar, MSD), speakers bureau (Roche, Clovis, Astra Zeneca, MSD), outside the submitted work. EE reports personal fees from Roche, outside the submitted work. JF reports advisory/consultancy (Amgen, Ipsen, Eisai, Merck, Roche, Novartis) and others (Amgen), outside the submitted work. AR reports honoraria and advisory/consultancy (AstraZeneca, Roche, Tesaro, Clovis, PharmaMar, Lilly, Amgen), honoraria (Eisai), research grant/funding to institution (Eisai, PharmaMar, Roche), travel/accommodation/expenses (AstraZeneca, Tesaro, PharmaMar, Roche), and others (Amgen), outside the submitted work. The remaining authors (JR-P, JB, MM, AB, GC, BC, AH, DH) have declared no conflicts of interest.
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Gallego, A., Ramon-Patino, J., Brenes, J. et al. Bevacizumab in recurrent ovarian cancer: could it be particularly effective in patients with clear cell carcinoma?. Clin Transl Oncol 23, 536–542 (2021). https://doi.org/10.1007/s12094-020-02446-z
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DOI: https://doi.org/10.1007/s12094-020-02446-z