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Invasive and in situ cervical cancer associated with pregnancy: analysis from the French cancer network (CALG: Cancer Associé à La Grossesse)

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Abstract

Purpose

To describe the oncologic and obstetric outcomes of patients diagnosed with invasive cervical cancer (ICC) and in situ adenocarcinoma (ISA) during pregnancy or during the year following delivery.

Methods

This retrospective observational study involved a cohort of 28 patients diagnosed with invasive cervical cancer (20 patients) or in situ adenocarcinoma (eight patients) during pregnancy or during the year following delivery who received expert opinion from physicians of the Cancer Associé à La Grossesse (CALG) network between 2005 and 2018. Descriptive results were expressed in median, range and interquartile range (IQR).

Results

Between 2005 and 2018, 20 patients with ICC and eight with ISA received expert opinion from physicians of the CALG network. Both ICC and ISA were mostly diagnosed during pregnancy with a median term at diagnosis of 23.3 weeks of gestation (WG) for ICC and 7.3 WG for ISA. Overall, the median age at diagnosis for both ICC and ISA was 33 years. Most ICCs (n = 9) had FIGO stage ≥ IB2 and five underwent neoadjuvant chemotherapy at a median term of 22.5 WG. Seventeen patients with ICC underwent surgery. Three patients had medical termination of the pregnancy. Two patients experienced recurrence and three died. Median time of follow-up was 59.3 months (IQR 30.5–129.2).

Conclusion

Management of cervical cancer during pregnancy is challenging especially in terms of maternal outcomes with a relative poor prognosis requiring a multidisciplinary expert advice.

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Data availability

Data supporting the results reported in the article can be found by requested and the corresponding author.

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Department of Gynaecology and Obstetrics, Tenon University Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), University Pierre-et-Marie-Curie Paris VI, Institut Universitaire de Cancérologie (IUC), Paris, France

    A. Puchar, A. S. Boudy, L. Selleret, A. Arfi, C. Owen, S. Bendifallah & E. Darai

  2. Centre CALG (Cancer Associé à La Grossesse), Paris, France

    A. Puchar, A. S. Boudy, L. Selleret, A. Arfi, C. Owen, S. Bendifallah & E. Darai

  3. UMRS-938 4, Faculté de Médecine Sorbonne Université, Paris, France

    S. Bendifallah & E. Darai

Authors
  1. A. Puchar
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  2. A. S. Boudy
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  3. L. Selleret
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  4. A. Arfi
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  5. C. Owen
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  6. S. Bendifallah
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  7. E. Darai
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Contributions

AP made the analysis and wrote the article; ASB implement the database and helped write the manuscript; LS, AA and CO implement the database; SB helped write the manuscript; DE helped write the manuscript.

Corresponding author

Correspondence to A. Puchar.

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Conflict of interest

The authors declare no conflict of interest.

Ethical approval

The Ethical Review Committee (CEROG) approved this study (CEROG 2019-GYN-603). Written informed consent was obtained from all patients. The study was performed in accordance with the Declaration of Helsinki.

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Our manuscript doesn’t contain any individual person’s data in any form (including individual details, images or videos).

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Study conducted in Tenon University Hospital, Paris, France.

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Puchar, A., Boudy, A.S., Selleret, L. et al. Invasive and in situ cervical cancer associated with pregnancy: analysis from the French cancer network (CALG: Cancer Associé à La Grossesse). Clin Transl Oncol 22, 2002–2008 (2020). https://doi.org/10.1007/s12094-020-02343-5

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  • DOI: https://doi.org/10.1007/s12094-020-02343-5

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