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Diagnostic efficiency of Sestamibi gammagraphy and Doppler sonography in the preoperative assessment of breast lesions

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Abstract

Introduction

It would be desirable to have preoperative methods that allow an adequate selection of patients with breast lesions to rule out breast cancer: The aim of the present study is to evaluate the efficiency of preoperative Sestamibi gammagraphy and Doppler sonography regarding the differential diagnosis of malignancy in breast lesions.

Material and methods

A prospective observational study was conducted on 88 consecutive patients with breast lesions. All the patients underwent preoperative Doppler sonogrpahy with an echo-enhancing agent and Sestamibi gammagraphy. All the patients had histopathological study of the surgical specimen to compare with the result of the preoperative techniques. These comparations were done both for the overall series and separately for palpable and non-palpable lesions.

Results

In the overall series results, both tests separately and the two combined, are related significantly to the malignant histological diagnosis (p<0.001). In palpable lesions, there is a considerable increase in sensitivity, and especially in specificity, attaining 100%, with the combination of both tests. In non-palpable lesions, a relationship was only found between the results of the Sestamibi gammagraphy and the malignant histological diagnosis (93.3%; p<0.05).

Conclusions

Sestamibi gammagraphy and Doppler sonography are two efficient exploratory techniques in the preoperative assessment of malignancy in breast lesions, especially for palpable lesions, and this efficiency is greater when they are combined.

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Authors and Affiliations

  1. Breast Surgery Unit, Department of General Surgery, Virgen de la Arrixaca University Hospital, 3rd floor, 30120 El Palmar, Murcia, Spain

    Antonio Piñero, Pedro José Galindo, Julián Illana & Pascual Parrilla

  2. Department of Nuclear Medicine, Virgen de la Arrixaca University Hospital, Murcia, Spain

    Francisco Nicolás

  3. Department of Radiology, Virgen de la Arrixaca University Hospital, Murcia, Spain

    Manuel Reus, María Dolores Hernández & Isidro Durán

  4. Department of Statistics, School of Medicine, Murcia, Spain

    Manuel Canteras

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  1. Antonio Piñero
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  2. Pedro José Galindo
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  3. Julián Illana
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  4. Francisco Nicolás
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  9. Pascual Parrilla
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Correspondence to Antonio Piñero.

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Piñero, A., Galindo, P.J., Illana, J. et al. Diagnostic efficiency of Sestamibi gammagraphy and Doppler sonography in the preoperative assessment of breast lesions. Clin Transl Oncol 8, 103–107 (2006). https://doi.org/10.1007/s12094-006-0166-x

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  • DOI: https://doi.org/10.1007/s12094-006-0166-x

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