Abstract
Cancer is a cellular impairment disorder characterized by the loss of cell cycle regulation leading to aberrant cell proliferation. Cell–cell communication plays a crucial role in cell signaling which is highly disrupted in various malignancies. Tight junctions (TJs) are major proteins that regulate the proper communication, and the dysregulation of TJ proteins makes these tumor cells more aggressive, leading to tumor invasion and metastasis. Hence targeting TJs might be a novel insight towards addressing these highly invasive, metastatic tumors. Due to the prohibitive costs of treatments, side effects, and development of resistance, herbal medications comprising bioactive ingredients have become more popular for various human ailments. Unfortunately, the importance of natural compounds has significantly reduced due to the development of modern synthetic techniques to formulate drugs. However, the pharmaceutical industry that adopts chemistry-based drug development in combination with high throughput synthesis have not resulted in the expected drug productivity. Hence, the focus was shifted back to natural compounds in search of novel drugs with advanced technology to isolate the biologically active compound from the natural ones. The current review delivers the importance of TJ regulation, promoting it through phytochemicals to target malignant tumor cells.
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Acknowledgements
SLP gratefully acknowledges DBT (BT/PR30629/BIC/101/1093/2018), New Delhi; UGC (Ref No: No.F.30–456/2018 (BSR), SERB (Ref No.: PDF/2015/000867), and GITAM-RSG for the financial support. PC gratefully acknowledges DBT (BT/PR30629/BIC/101/1093/2018), New Delhi, for the Junior research fellowship.
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Wrote the manuscript: PC and SLP; figures and tables: PC and JANM; Review and Editing: JANM, GJM, and SNSL; data compiling: GJM and SNSL; Conceptualized the study: SLP. Overall supervision of the study: SLP.
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Pandrangi, S.L., Chittineedi, P., Mohiddin, G.J. et al. Cell–cell communications: new insights into targeting efficacy of phytochemical adjuvants on tight junctions and pathophysiology of various malignancies. J. Cell Commun. Signal. 17, 457–467 (2023). https://doi.org/10.1007/s12079-022-00706-x
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DOI: https://doi.org/10.1007/s12079-022-00706-x