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The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence

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Journal of Cell Communication and Signaling Aims and scope

Abstract

Chemokines are immune system mediators that mediate various activities and play a role in the pathogenesis of several cancers. Among these chemokines, C-X-C motif chemokine 17 (CXCL-17) is a relatively novel molecule produced along the airway epithelium in physiological and pathological conditions, and evidence shows that it plays a homeostatic role in most cases. CXCL17 has a protective role in some cancers and a pathological role in others, such as liver and lung cancer. This chemokine, along with its possible receptor termed G protein-coupled receptor 35 (GPR35) or CXCR8, are involved in recruiting myeloid cells, regulating angiogenesis, defending against pathogenic microorganisms, and numerous other mechanisms. Considering the few studies that have been performed on the dual role of CXCL17 in human malignancies, this review has investigated the possible pro-tumor and anti-tumor roles of this chemokine, as well as future treatment options in cancer therapy.

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Acknowledgements

Rafsanjan University of Medical Sciences supported this study.

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Authors and Affiliations

  1. School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Seyyede Fatemeh Hashemi

  2. Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

    Hossein Khorramdelazad

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  1. Seyyede Fatemeh Hashemi
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  2. Hossein Khorramdelazad
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Correspondence to Hossein Khorramdelazad.

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Hashemi, S.F., Khorramdelazad, H. The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence. J. Cell Commun. Signal. 17, 409–422 (2023). https://doi.org/10.1007/s12079-022-00699-7

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