Skip to main content
SpringerLink
Log in

CCN1 promotes vascular endothelial growth factor secretion through αvβ3 integrin receptors in breast cancer

  • Published:
Journal of Cell Communication and Signaling Aims and scope

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  • Babic AM, Kireeva ML, Kolesnikova TV, Lau LF (1998) CCN1, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Proc Natl Acad Sci U S A 95:6355–6360

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Babic AM, Chen CC, Lau LF (1999) Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin αvβ3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol Cell Biol 19:2958–2966

    PubMed Central  PubMed  CAS  Google Scholar 

  • Boudreau N, Myers C (2003) Breast cancer-induced angiogenesis: multiple mechanisms and the role of the microenvironment. Breast Cancer Res 5:140–146

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Brigstock DR (2002) Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CCN1). Angiogenesis 5:153–165

    Article  PubMed  CAS  Google Scholar 

  • Carron CP, Meyer DM, Pegg JA et al (1998) A peptidomimetic antagonist of the integrin αvβ3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy. Cancer Res 58:1930–1935

    PubMed  CAS  Google Scholar 

  • Chen CC, Mo FE, Lau LF (2001) The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. J Biol Chem 276:47329–47337

    Article  PubMed  CAS  Google Scholar 

  • Chen N, Leu SJ, Todorovic V, Lam SC, Lau LF (2004) Identification of a novel integrin αvβ3 binding site in CCN1 (CCN1) critical for pro-angiogenic activities in vascular endothelial cells. The J Biol Chem 279:44166–44176

    Article  CAS  Google Scholar 

  • Dean RA, Butler GS, Hamma-Kourbali Y et al (2007) Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis. Mol Cell Biol 27:8454–8465

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Gasparini G (2001) Clinical significance of determination of surrogate markers of angiogenesis in breast cancer. Crit Rev Oncol Hematol 37:97–114

    Article  PubMed  CAS  Google Scholar 

  • Grote K, Salguero G, Ballmaier M, Dangers M, Drexler H, Schieffer B (2007) The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration. Blood 110:877–885

    Article  PubMed  CAS  Google Scholar 

  • Hashimoto G, Inoki I, Fujii Y, Aoki T, Ikeda E, Okada Y (2002) Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165. J Biol Chem 277:36288–36295

    Article  PubMed  CAS  Google Scholar 

  • Ivkovic S, Yoon BS, Popoff SN et al (2003) Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development (Cambridge, England) 130:2779–2791

    Article  CAS  Google Scholar 

  • Kern FG, Lippman ME (1996) The role of angiogenic growth factors in breast cancer progression. Cancer Metastasis Rev 15:213–219

    Article  PubMed  CAS  Google Scholar 

  • Leek RD (2001) The prognostic role of angiogenesis in breast cancer. Anticancer Res 21:4325–4331

    PubMed  CAS  Google Scholar 

  • Leu SJ, Lam SC, Lau LF (2002) Pro-angiogenic activities of CCN1 (CCN1) mediated through integrins αvβ3 and α6β1 in human umbilical vein endothelial cells. J Biol Chem 277:46248–46255

    Article  PubMed  CAS  Google Scholar 

  • Lin CG, Leu SJ, Chen N et al (2003) CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. J Biol Chem 278:24200–24208

    Article  PubMed  CAS  Google Scholar 

  • Locopo N, Fanelli M, Gasparini G (1998) Clinical significance of angiogenic factors in breast cancer. Breast Cancer Res Treat 52:159–173

    Article  PubMed  CAS  Google Scholar 

  • Menendez JA, Vellon L, Mehmi I, Teng PK, Griggs DW, Lupu R (2005) A novel CCN1-triggered ‘CCN1-alphavbeta3 integrin loop’ regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway. Oncogene 24:761–779

    Article  PubMed  CAS  Google Scholar 

  • Planque N, Perbal B (2003) A structural approach to the role of CCN (CCN1/CTGF/NOV) proteins in tumourigenesis. Cancer Cell Int 3:15

    Article  PubMed Central  PubMed  Google Scholar 

  • Rayson D, Vantyghem SA, Chambers AF (1999) Angiogenesis as a target for breast cancer therapy. J Mammary Gland Biol Neoplasia 4:415–423

    Article  PubMed  CAS  Google Scholar 

  • Saaristo A, Karpanen T, Alitalo K (2000) Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis. Oncogene 19:6122–6129

    Article  PubMed  CAS  Google Scholar 

  • Shannon KE, Keene JL, Settle SL et al (2004) Anti-metastatic properties of RGD-peptidomimetic agents S137 and S247. Clin Exp Metastasis 21:129–138

    Article  PubMed  CAS  Google Scholar 

  • Shimo T, Nakanishi T, Nishida T et al (1999) Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo. J Biochem 126:137–145

    Article  PubMed  CAS  Google Scholar 

  • Sledge GW Jr (2002) Vascular endothelial growth factor in breast cancer: biologic and therapeutic aspects. Semin Oncol 29:104–110

    Article  PubMed  CAS  Google Scholar 

  • Tsai MS, Hornby AE, Lakins J, Lupu R (2000) Expression and function of CCN1, an angiogenic factor, in breast cancer cell lines and tumor biopsies. Cancer Res 60:5603–5607

    PubMed  CAS  Google Scholar 

  • Tsai MS, Bogart DF, Castaneda JM, Li P, Lupu R (2002) Cyr61 promotes breast tumorigenesis and cancer progression. Oncogene 21:8178–8185

    Article  PubMed  CAS  Google Scholar 

  • Vellon L, Menendez JA, Lupu R (2005) αvβ3 integrin regulates heregulin (HRG)-induced cell proliferation and survival in breast cancer. Oncogene 24:3759–3773

    Article  PubMed  CAS  Google Scholar 

  • Xie D, Miller CW, O’Kelly J et al (2001a) Breast cancer. Cyr61 is overexpressed, estrogen-inducible, and associated with more advanced disease. J Biol Chem 276:14187–14194

    PubMed  CAS  Google Scholar 

  • Xie D, Nakachi K, Wang H, Elashoff R, Koeffler HP (2001b) Elevated levels of connective tissue growth factor, WISP-1, and CCN1 in primary breast cancers associated with more advanced features. Cancer Res 61:8917–8923

    PubMed  CAS  Google Scholar 

  • Yang GP, Lau LF (1991) Cyr61, product of a growth factor-inducible immediate early gene, is associated with the extracellular matrix and the cell surface. Cell Growth Differ 2:351–357

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We thank Dr. Cheol Hong-Park of the Mayo Clinic for his assistance in the preparation of the figures presented in this manuscript. This work was supported by NIH award number R01 CA118975 (to RL).

Author information

Authors and Affiliations

  1. Department of Medicine and Experimental Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Ingrid Espinoza, Chandra Mohan KVP & Ruth Lupu

  2. Catalan Institute of Oncology and Girona Biomedical Research Institute, Avenida de Francia S/N, 17007, Girona, Catalonia, Spain

    Javier A. Menendez

  3. Mayo Clinic Cancer Center, Rochester, MN, USA

    Ingrid Espinoza & Ruth Lupu

Authors
  1. Ingrid Espinoza
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Javier A. Menendez
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chandra Mohan KVP
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ruth Lupu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ruth Lupu.

Additional information

Ingrid Espinoza and Javier A. Menendez contributed equally.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Espinoza, I., Menendez, J.A., KVP, C.M. et al. CCN1 promotes vascular endothelial growth factor secretion through αvβ3 integrin receptors in breast cancer. J. Cell Commun. Signal. 8, 23–27 (2014). https://doi.org/10.1007/s12079-013-0214-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12079-013-0214-6

Keywords

Search

Navigation