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The contribution of adhesion signaling to lactogenesis

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Journal of Cell Communication and Signaling Aims and scope

Abstract

The mammary gland undergoes hormonally controlled cycles of pubertal maturation, pregnancy, lactation, and involution, and these processes rely on complex signaling mechanisms, many of which are controlled by cell–cell and cell–matrix adhesion. The adhesion of epithelial cells to the extracellular matrix initiates signaling mechanisms that have an impact on cell proliferation, survival, and differentiation throughout lactation. The control of integrin expression on the mammary epithelial cells, the composition of the extracellular matrix and the presence of secreted matricellular proteins all contribute to essential adhesion signaling during lactogenesis. In vitro and in vivo studies, including the results from genetically engineered mice, have shed light on the regulation of these processes at the cell and tissue level and have led to increased understanding of the essential signaling components that are regulated in temporal and cell specific manner during lactogenesis. Recent studies suggest that a secreted matricellular protein, CTGF/CCN2, may play a role in lactogenic differentiation through binding to β1 integrin complexes, enhancing the production of extracellular matrix components and contributions to cell adhesion signaling.

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The authors acknowledge support from the United States Military Cancer Institute.

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  1. Bethanie Morrison

    Present address: Drug Mechanism Group, Developmental Therapeutics Program, SAIC Frederick/NCI-FCRDC, Frederick, MD, USA

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  1. Department of Pathology, Uniformed Services University, Rm B3122, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA

    Bethanie Morrison & Mary Lou Cutler

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Morrison, B., Cutler, M.L. The contribution of adhesion signaling to lactogenesis. J. Cell Commun. Signal. 4, 131–139 (2010). https://doi.org/10.1007/s12079-010-0099-6

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