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A rare case of extragastrointestinal stromal tumor of vocal cord - case report

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Abstract

Gastrointestinal stromal tumors (GISTs) are the mesenchymal tumors of the gastrointestinal tract. Extra Gastrointestinal stromal tumors (EGISTs) are rare neoplasms that occur outside the gastrointestinal tract [1]. Miettinen et al. [2] described the first EGIST in 1999. EGIST accounts for 10% of all GISTs [3]. The main distinction between GIST and EGIST is the site of origin of the primary tumor, as GIST occurs throughout the GI tract, from the esophagus to the anus, whereas EGIST is a tumor without any connection with the intestinal wall and are reported in the retroperitoneum, mesentery, and omentum [4]. Hu et al. [5] reported a first case report of EGIST of larynx.We present a second case report of Extra-gastrointestinal stromal tumor of larynx a 47-year-old male reported to ENT Department Command Hospital Central Command Lucknow with complaints of Hoarseness. On examination found to have right vocal cord growth for which he underwent excision of right vocal cord growth. Histopathological examination showed typical of a spindle-cell GIST, showing strong immunoreactivity for CD 117, DOG1, Vimentin and CD 99. 6 months follow up post surgery with no recurrence.

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Data availability

The data that support the findings of this study are available from Command Hospital Central Command Lucknow, but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the authors upon reasonable request and with permission of Command Hospital Central Command Lucknow.

References

  1. Hatipoglu E (2018) Extragastrointestinal stromal tumor (EGIST): a 16-year experience of 13 cases diagnosed at a single center. Med Sci Monit 24:3301

    Article  PubMed  PubMed Central  Google Scholar 

  2. Miettinen M, Monihan JM, Sarlomo-Rikala M et al (1999) Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: Clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol 23(9):1109–1118

    Article  CAS  PubMed  Google Scholar 

  3. Du CY, Shi YQ, Zhou Y et al (2008) The analysis of status and clinical implication of KIT and PDGFRA mutations in gastrointestinal stromal tumor (GIST). J Surg Oncol 98(3):175–178

    Article  PubMed  Google Scholar 

  4. Reith JD, Goldblum JR, Lyles RH, Weiss SW (2000) Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol 13(5):577–578

    Article  CAS  PubMed  Google Scholar 

  5. Hu A, Koch L, Merati AL (2013) Pathology quiz case 1. Diagnosis: gastrointestinal stromal tumor (GIST) of the larynx with cervical metastases. JAMA Otolaryngol Head Neck Surg 139(6):649–651

    Article  PubMed  Google Scholar 

  6. Miettinen M, Lasota J (2001) Gastrointestinal stromal tumors - definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Archiv: Int J Pathol 438:1–12. https://doi.org/10.1007/s004280000338

    Article  CAS  Google Scholar 

  7. Fletcher CD, Berman JJ, Corless C et al (2002) Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol 33(5):459–465

    Article  PubMed  Google Scholar 

  8. Miettinen M, Sarlomo-Rikala J, Lasota J (1999) Gastrointestinal stromal tumors – new findings on their biology. A review. Hum Pathol 23:1209–1220

    Google Scholar 

  9. Zheng S, Huang K-e, Tao D-y, Pan Y-l (2011) Gene mutations and prognostic factors analysis in extragastrointestinal stromal tumor of a Chinese three-center study. 15(4):675–681J Gastrointest Surg.

  10. Vij M, Agrawal V, Pandey R (2011) Malignant extra-gastrointestinal stromal tumor of the pancreas. A case report and review of literature. J Pancreas 12(2):200–413

    Google Scholar 

  11. Weppler E, Gaertner E (2005) Malignant extragastrointestinal stromal tumor presenting as a vaginal mass: report of an unusual case with literature review. J Gynecol Cancer 15(6):1169–1172

    Article  CAS  Google Scholar 

  12. Agaimy A, Wünsch P (2006) Gastrointestinal stromal tumours: a regular origin in the muscularis propria, but an extremely diverse gross presentation. Langenbecks Arch Surg 391(4):322–329

    Article  PubMed  Google Scholar 

  13. Blackstein ME, Rankin B, Fletcher C, Heinrich M, Benjamin R, Mehren MV (2005) etal.Clinical benefit of Imatinib in patients with metastatic GIST negative for the expression of CD117 in the S0033 trial. ASCO. J Clin Oncol ;9010

  14. Dorfman DM, Bui MM, Tubbs RR, His ED, Fitzgibbons PL, Linden MD (2006) CD117 immunohistochemistry tissue microarray survey for quality assurance and interlaboratory comparison: a college of American pathologists cell markers committee study. Arch Pathol Lab Med 130:779–782

    Article  CAS  PubMed  Google Scholar 

  15. Raut CP, Morgan JA, Ashley SW (2007) Current issues in gastrointestinal stromal tumors: incidence, molecular biology, and contemporary treatment of localized and advanced disease. Curr Opin Gastroenterol 23:149–158

    Article  PubMed  Google Scholar 

  16. Miettinen M Are desmoid tumors kit positive? Am. J Surg Pathol 2001 Apr ;25(4):549–550

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Authors and Affiliations

  1. Department of ENT, Head and Neck Surgery, Command Hospital Central Command, Cariappa Road, Lucknow, Uttar Pradesh, 226002, India

    Omvir Singh Chahar, Lohith BR, Sheetal Raina, Krishna Dev Singh, Shailendra Tripathi, Ombir Singh & Nandini Bisht

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  1. Omvir Singh Chahar
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  2. Lohith BR
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  3. Sheetal Raina
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  4. Krishna Dev Singh
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  5. Shailendra Tripathi
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  6. Ombir Singh
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  7. Nandini Bisht
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Contributions

Omvir Singh Chahar, Lohith BR: Design, Conduct, Analysis, Presentation of research; Sheetal Raina, Krishna Dev Singh, Shailendra Tripathi: Design, Conduct, Presentation of research; Ombir Singh, Dr Nandini: Conduct, Analysis.

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Correspondence to Lohith BR.

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Ethical Clearance was taken from the Institutional Ethics committee. The authors assert that all the procedures contributing to the present work comply with the ethical standards of the relevant national and institutional guidelines on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. Informed and written consent was obtained from the patient.

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Chahar, O.S., BR, L., Raina, S. et al. A rare case of extragastrointestinal stromal tumor of vocal cord - case report. Indian J Otolaryngol Head Neck Surg (2024). https://doi.org/10.1007/s12070-024-04652-5

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