Abstract
In the present study we aim to evaluate serum vitamin D levels in participants having tinnitus with normal audiometric findings. Total 98 participants in the age range 20–70 year were included in the study. Participants underwent detail case history, ear examination, pure tone audiometry and impedance audiometry. 68 participants with subjective tinnitus for more than 3 months and with normal audiometric thresholds and “A” type tympanogram were included in study group and 30 participants without tinnitus in the control group. The participants fullfillng the inclusion criteria underwent thorough tinnitus evaluation which included administration of tinnitus severity index tinnitus handicap inventory, psychophysical evaluation of tinnitus (pitch matching, loudness matching) and assessment of Vitamin D levels. It was seen that the mean Vitamin D levels were significantly lower in study group, and out of 68 participants only 11 had optimal Vitamin D levels, 57 (83%) had Vitamin D levels less that 30 mg/dl. In the control group 20 (66%) had vitamin D deficiency. The difference came out to be statistically significant. Our study suggests that there is a link between vitamin D and tinnitus, in view of these findings we recommend evaluating serum Vitamin D levels in patients of chronic idiopathic tinnitus, especially in adults with normal hearing. Our study suggests vitamin D deficiency may be one of the risk factor for tinnitus in people with normal hearing in the absence of other manifestations.
Similar content being viewed by others
References
Carla Salles Chamouton (2021) Helenice Yemi nakamura Profile and prevalence of people with tinnitus:a healthy servey. CoDAS 33(6):e202000293
Oosterloo BC, Croll PH, Baatenburg de Jong RJ, Ikram MK, Goedegebure A (2021) Prevalence of Tinnitus in an Aging Population and its relation to Age and hearing loss. Otolaryngol Head Neck Surg 164(4):859–868. https://doi.org/10.1177/0194599820957296
Fife td Michael j,aminoff,robert b.daroffencyclopediaof the neurological sciences.2003.p.541-4
Jung SY, Kim SH, Yeo SG (2019) Association of Nutritional Factors with Hearing Loss. Nutrients. ;11(2):307. Published 2019 Feb 1. doi:https://doi.org/10.3390/nu11020307
Puga AM, Pajares MA, Varela-Moreiras G, Partearroyo T (2018) Interplay between Nutrition and Hearing Loss: State of Art. Nutrients. ;11(1):35. Published 2018 Dec 24. doi:https://doi.org/10.3390/nu11010035
Dawes P, Cruickshanks KJ, Marsden A, Moore DR, Munro KJ (2020) Relationship between Diet, Tinnitus, and hearing difficulties. Ear Hear 41(2):289–299. https://doi.org/10.1097/AUD.0000000000000765
Brooks GB (1985) Vitamin D defeciency and otosclerosis.Otolaryngol. Head Neck Surg 93:313–321
Ghazavi H, Kargoshaie AA, Jamshidi koohsari M (2020) Investigation of vitamin D levels in patents with sudden sensory-nural hearing loss and its effect on treatment. Am J Otolaryngol 41:102327
GrovesNJ McGrathJJ,BurneTH.VitaminD as a neurosteroid affecting the developing and adult brain.Annu Rev Nutr.2014;34;117 – 41]
Anjum I, Jaffery SS, Fayyaz M, Samoo Z, Anjum S (2018) The Role of Vitamin D in Brain Health: A Mini Literature Review. Cureus. ;10(7):e2960. Published 2018 Jul 10. doi:https://doi.org/10.7759/cureus.2960
Salamah M, Alghamdi A, mANIA,K et al (2022) Association between vitamin D and ear disease :a meta analysis and systematic review. Egypt J Otolaryngol 38:27
BukivB,Junger H, Lundberg YW (2018) Vitamin D supplimentation may improve symptoms. Meniere’s Disease Med hypothesis 116:44–46
Yang B, Lu Y, Xing D, Zhong W, Tang Q, Liu J et al (2020) Association between serum vitamin D levels and benign paroxysmal positional vertigo: a systematic review and meta-analysis of observational studies. Eur Arch Otorhinolaryngol 277:169–177 0255482
Taneja MK (2020) Prevention and Rehabilitation of Old Age Deafness. Indian J Otolaryngol Head Neck Surg 72:524–531
serum vitamin D concentration is lower in patents with tinnitus:a meta analysis of observational studies
Worldwide vitamin D status.van Schoor NM, Lips P.Best Pract Res Clin Endocrinol Metab. 2011 Aug; 25(4):671 – 80
Guest H, Munro KJ, Prendergast G, Howe S, Plack CJ (2017) Tinnitus with a normal audiogram: relation to noise exposure but no evidence for cochlear synaptopathy. Hear Res 344:265–274. https://doi.org/10.1016/j.heares.2016.12.002
Liberman MC (2017) Noise-induced and age-related hearing loss: new perspectives and potential therapies. F1000Res 6:927 Published 2017 Jun 16. https://doi.org/10.12688/f1000research.11310.1
Yang CW, Byun JY (2016)Tinnitus Assessment.Hanyang Med Rev:109–112.
Nowaczewska M, Osiński S, Marzec M, Wiciński M, Bilicka K, Kaźmierczak W (2021) The role of vitamin D in subjective tinnitus-A case-control study. PLoS ONE 16(8):e0255482 Published 2021 Aug 18. https://doi.org/10.1371/journal.pone
Abdelmawgoud S (2021) Vitamin D level and its relation to Tinnitus. Egypt J Ear Nose Throat Allied Sci 22(22):1–5. https://doi.org/10.21608/ejentas.2020.37810.124
Bousema EJ, Koops EA, van Dijk P, Dijkstra PUAssociation Between Subjective Tinnitus and Cervical Spine or Temporomandibular Disorders: A Systematic Review.Trends Hear. 2018 JanDec; 22():2331216518800640
Haider HF, Ribeiro SF, Martins C, Ribeiro D, Trigueiros N, Szczepek AJ, Caria H, Hoare DJ, Paço J (2020 May) Borrego LMTinnitus, hearing loss and inflammatory processes in an older portuguese population. Int J Audiol 59(5):323–332
Roffe-Vazquez DN, Huerta-Delgado AS, Castillo EC et al (2019) Correlation of vitamin D with inflammatory cytokines, atherosclerotic parameters, and lifestyle factors in the setting of Heart failure: a 12-Month Follow-Up study. Int J Mol Sci 20(22):5811 Published 2019 Nov 19. https://doi.org/10.3390/ijms20225811
Ausland JH-L, Engdahl B, Oftedal B, Steingrímsdóttir ÓA, Nielsen CS, Hopstock LA et al (2021) Tinnitus and associations with chronic pain: the population-based Tromsø Study (2015–2016). PLoS ONE 16(3):e0247880. https://doi.org/10.1371/journal.pone.0247880
IikuniF,NomuraY (2013 Oct) FumiyukiG,MurakamiM,ShigiharaS,IkedaM.Why do patients with fibromyalgia complain of ear-related symptoms? Ear-related symptoms and otological findings in patients with fibromyalgia.Clin Rheumatol. 32:1437–1441. https://doi.org/10.1007/s10067-013-2287-2. Epub 2013 May 23 10
SalviR AH, BurkardR J, WackD S.Neuroanatomy of tinnitus (1999) F, GalantowiczP J, CoadM L,. Scand Audiol Suppl. ;51:47–52.[28]Neville JJ, Palmieri T, Young ARPhysical Determinants of Vitamin D Photosynthesis: A Review.JBMR Plus. 2021 Jan; 5(1):e10460
AlQuaiz AM, Kazi A, Fouda M, Alyousefi N Age and gender differences in the prevalence and correlates of vitamin D deficiency.Arch Osteoporos.2018 Apr29; 13(1):49
Kuchuk NO, Pluijm SM, van Schoor NM et al (2009) Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons, J Clin Endocrinol Metab, vol. 94 (pg. 1244-50)
Costanzo PR, Elías NO, Kleiman RubinszteinJ et al (2011) Ultraviolet radiation impact on seasonal variations of serum 25-hydroxy-vitamin D in healthy young adults in Buenos Aires. Med (B Aires) 71:336–342
Kapil U, Pandey RM, Goswami R et al (2017) Prevalence of vitamin D deficiency and associated risk factors among children residing at high altitude in Shimla district, Himachal Pradesh, India. Indian J Endocrinol Metab 21(1):178–183. https://doi.org/10.4103/2230-8210.196031
Raj-Koziak D, Gos E, Świerniak W, Karpiesz L, Niedziałek I, Włodarczyk E et al (2019) RelationshipBetween Tinnitus Loudness measure by Visual Analogue Scale and Psychoacoustic Matching of Tinnitus Loudness. Otol Neurotol 40(1):16–21
Al-Swiahb JN, Hwang ES, Kong JS, Kim WJ, Yeo SW, Park SN (2016) Clinical and audiologic characteristics of patients with sensorineural tinnitus and its association with psychological aspects: an analytic retrospective study. Eur Arch Otorhinolaryngol 273(12):4161–4165
Kim SY, Jeon SW, Lim WJ, Oh KS, Shin DW, Cho SJ et al (2020) The relationship between serum vitamin D levels, C-Reactive protein, and anxiety symptoms. Psychiatry Investig
Isabel D, Francisco S, Pedro CAssessing Auditory Processing deficits in Tinnitus and hearing impaired Patientswith the Auditory BehaviorQuestionnaire.Frontiers in Neuroscience.11.2017 https://doi.org/10.3389/fnins.2017.00187
Anderson AJ Vingry AJ.Small samples:does size matter?InvestOpthalmol Vis Sci. 2001 Jun42(7):1411–3.PMID:11381039
Funding
This study received no external funding.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
There are no conflict of intersest.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Sharma, D., Gupta, V., Bhatia, S. et al. Association of Vitamin D Deficiency in Patients with Tinnitus with Normal Audiogram. Indian J Otolaryngol Head Neck Surg 75, 1992–1999 (2023). https://doi.org/10.1007/s12070-023-03751-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12070-023-03751-z