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Association between Serum Vitamin D Levels and Risk of Sudden Sensorineural Hearing Loss: A cross-sectional Study

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Background

Sudden sensorineural hearing loss (SSNHL) is an autoimmune diseases of the inner ear which is usually defined by acute onset of hearing loss in one or both ears, of 30 dB or more on at least three contiguous audiometric frequencies within 3 days or less. This study aimed to compare the serum levels of 25-hydroxyvitamin D (VitD) between patients with SSNHL and healthy controls.

Methods

A total of 50 patients with SSNHL and 50 healthy individuals without hearing loss as control group were enrolled in this study. Serum levels of VitD and other related laboratory tests such as calcium (Ca), phosphorus (P), and parathyroid hormone (PTH) were measured and compared between two study groups.

Results

Serum level of VitD was significantly lower in patients suffering from SSNHL compared to the healthy controls (26.55 ± 14.44 vs. 33.51 ± 14.21, P = 0.017, respectively). VitD insufficiency was observed in 70% (n = 35) of the patients with SSNHL as compared to 44% (n = 22) of healthy individuals, demonstrating a significant difference between two study groups. However, no statistically difference was observed for serum levels of Ca, P, and PTH.

Conclusion

This study indicated an increased prevalence of VitD insufficiency in subjects with SSNHL, suggesting a possible association between serum VitD levels and the development of SSNHL. VitD may protect the hearing loss through its antioxidant role.

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Data Availability

All data generated or analyzed during this study are included in this article. Further enquiries can be directed to the corresponding author.

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Acknowledgements

We would like to thank all the study participants, as well as staff of Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, for their kindly cooperation. This work was supported by Research Project No. 4000720 as ENT residency dissertation.

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Author notes

  1. Afshin Zandi and Hassan Mehrad-Majd contributed equally to this work.

Authors and Affiliations

  1. Sinus and Surgical Endoscopic Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Afshin Zandi & Mohamad Reza Afzalzadeh

  2. Department of Otorhinolaryngology, Faculty of Medicine, Mashhad University of Medical Sciences, P.O. Box: 9176699199, Mashhad, Iran

    Afshin Zandi & Mohamad Reza Afzalzadeh

  3. Clinical Research Development Unit, Faculty of Medicine, Ghaem hospital, Mashhad University of Medical Sciences, Mashhad, Iran

    Hassan Mehrad-Majd

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  1. Afshin Zandi
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  2. Hassan Mehrad-Majd
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Contributions

Study concept and design: MRA, HMM, Acquisition of data: AZ, BR, ZMK Statistical analysis: HMM, Drafting of the manuscript: AZ, HMM, Study supervision: MRA.

Corresponding author

Correspondence to Mohamad Reza Afzalzadeh.

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Zandi, A., Mehrad-Majd, H. & Afzalzadeh, M.R. Association between Serum Vitamin D Levels and Risk of Sudden Sensorineural Hearing Loss: A cross-sectional Study. Indian J Otolaryngol Head Neck Surg 75, 2974–2978 (2023). https://doi.org/10.1007/s12070-023-03917-9

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  • DOI: https://doi.org/10.1007/s12070-023-03917-9

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