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Plasma Asymmetrıc Dımethylargınıne (ADMA) and Nıtrıc Oxıde (NO) Levels ın Patıents wıth Chronıc Pansınusıtıs

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Abstract

Chronic pansinusitis is a mucosal inflammation of the nose and all paranasal sinuses with severe inflammation of the upper airways. Asymmetric dimethylarginine (ADMA) is associated with oxidative stress. In this study, we aimed to examine the plasma levels and importance of ADMA and nitric oxide (NO) in patients with chronic pansinusitis. The study was conducted with a total of 64 patients. The study group included a total of 40 patients with chronic pansinusitis. (18 females, 22 males) (mean age 32.27 ± 10.02). The control group consisted of 24 patients (11 females and 13 males). The mean age of the patients in the control group was 31.35 ± 6.05 years. Nasal endoscopic examinations were performed in patients with a history of chronic pansinusitis and symptoms of chronic pansinusitis. Later, the diagnosis of chronic pansinusitis was confirmed with coronal paranasal sinus Computed tomography scans. Plasma ADMA levels were measured by ELISA method and NO levels were measured by Griess method. Plasma ADMA and NO levels of the patients and healthy volunteers were measured and the mean plasma levels of the two groups were compared. ADMA levels were significantly higher in the group with chronic pansinusitis compared to the control group (1.23 ± 0.41 μM and 0.28 ± 0.06 μM, respectively) (p < 0.001), while NO levels were significantly lower in the patient group compared to the control group (7.06 ± 1.07 μM and 12.25 ± 0.95, μM, respectively) (p < 0.001). Our results show that the increase in ADMA levels and the decrease in NO levels are associated with chronic pansinusitis. According to these results, increased plasma levels of ADMA in chronic pansinusitis may be useful in clinical use as a sign of increased oxidative stress.

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Funding

The present study has been supported by Istanbul Rumeli University, through the Scientific Research Project no: 2019010.

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Authors and Affiliations

  1. Private Çorlu REYAP Hospital, Department of Otorhinolaryngology, Istanbul Rumeli University, Istanbul, Turkey

    Fuat Bulut

  2. Vocational College of Health Services, Istanbul Rumeli University, Istanbul, Turkey

    Aylin Türksever Tetiker

  3. Department of Medical Biochemistry, Faculty of Medicine, Tekirdağ Namık Kemal University, Tekirdağ, Turkey

    Aliye Çelikkol

  4. Private Kurtköy Ersoy Hospital, Department of Otorhinolaryngology, Istanbul Yeni Yüzyıl Üniversity, Istanbul, Turkey

    Ayşe Sezim Şafak

  5. Department of Biostatistics, Faculty of Medicine, Tekirdağ Namık Kemal University, Tekirdağ, Turkey

    Birol Topçu

  6. Istanbul Bahcesehir University, Faculty of Medicine, Istanbul, Turkey

    Basak Ballica

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Correspondence to Fuat Bulut.

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Bulut, F., Türksever Tetiker, A., Çelikkol, A. et al. Plasma Asymmetrıc Dımethylargınıne (ADMA) and Nıtrıc Oxıde (NO) Levels ın Patıents wıth Chronıc Pansınusıtıs. Indian J Otolaryngol Head Neck Surg 74 (Suppl 2), 1591–1596 (2022). https://doi.org/10.1007/s12070-021-02720-8

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