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Audiological Profile in Primary Sjögren’s Syndrome in a Tertiary Care Setting and its Clinical Implications

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

This study aims to assess the frequency and the profile of hearing loss among patients with primary Sjögren’s syndrome in a tertiary care hospital in India and to look for an association between hearing loss and immunological parameters (anti-SSA antibody, anti-SSB antibody, anticardiolipin antibodies, complements C3 and C4). This prospective observational study was done from January 2011 to October 2011 on consecutive patients diagnosed with primary Sjögren’s syndrome in our tertiary care hospital. All patients underwent a puretone audiogram, tympanogram and acoustic reflex testing. The results of the tests were correlated with clinical and immunological findings. The frequency of audiometrically confirmed hearing loss in primary Sjögren’s syndrome was estimated to be 78.38 %, though only 17.24 % complained of hearing loss; minimal to mild sensorineural hearing loss were the most common varieties. The commonest finding on tympanometry was ‘A’ type curve and acoustic reflex was absent in 18.92 % of cases. There was no association between hearing loss and age, sicca symptoms, systemic symptoms or immunological test results in primary Sjögren’s syndrome. There was a high prevalence of hearing loss among patients with primary Sjögren’s syndrome, but most patients were unaware of this. Hearing assessment and regular monitoring of hearing thresholds is advisable for all patients with primary Sjögren’s syndrome.

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References

  1. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE et al (2002) Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61(6):554–558

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Shiboski SC, Shiboski CH, Criswell L, Baer A, Challacombe S, Lanfranchi H et al (2012) American College of Rheumatology classification criteria for Sjögren’s syndrome: a data-driven, expert consensus approach in the Sjögren’s international collaborative clinical alliance cohort. Arthritis Care Res 64(4):475–487

    Article  CAS  Google Scholar 

  3. Ramos-Casals M, Tzioufas A, Font J (2005) Primary Sjögren’s syndrome: new clinical and therapeutic concepts. Ann Rheum Dis 64(3):347–354

    Article  CAS  PubMed  Google Scholar 

  4. Soliotis F, Mavragani C, Moutsopoulos H (2004) Central nervous system involvement in Sjögren’s syndrome. Ann Rheum Dis 63(6):616–620

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Kassan SS, Moutsopoulos HM (2004) Clinical manifestations and early diagnosis of Sjögren syndrome. Arch Intern Med 164(12):1275–1284

    Article  PubMed  Google Scholar 

  6. Sandhya P, Jeyaseelan L, Scofield RH, Danda D (2015) Clinical characteristics and outcome of primary Sjogren’s syndrome: a large Asian Indian cohort. Open Rheumatol J 26(9):36–45

    Article  Google Scholar 

  7. Mc Cabe BF (1979) Autoimmune sensorineural hearing loss. Ann Otol Rhinol Laryngol 88:585–589

    Article  CAS  Google Scholar 

  8. Magaro M, Zoli A, Altomonte L, Mirone L, Corvino G, Di Girolamo S et al (1990) Sensorineural hearing loss in rheumatoid arthritis. Clin Exp Rheumatol 8(5):487–490

    CAS  PubMed  Google Scholar 

  9. Elwany S, el Garf A, Kamel T (1986) Hearing and middle ear function in rheumatoid arthritis. J Rheumatol 13(5):878–881

    CAS  PubMed  Google Scholar 

  10. Tumiati B, Casoli P, Parmeggiani A (1997) Hearing loss in the Sjögren syndrome. Ann Intern Med 126(6):450–453

    Article  CAS  PubMed  Google Scholar 

  11. Rauch SD, Cohen MA, Ruckenstein MJ (2010) Autoimmune inner ear disease. In: Flint PW, Haughey PH, Lund VJ, Niparko JK, Richardson MA, Robbins KY (eds) Cummings otolaryngology head and neck surgery, 5th edn. MOSBY Elsevier, Philadelphia

    Google Scholar 

  12. Andonopoulos AP, Naxakis S, Goumas P, Lygatsikas C (1995) Sensorineural hearing disorders in systemic lupus erythematosus. A controlled study. Clin Exp Rheumatol 13(2):137–141

    CAS  PubMed  Google Scholar 

  13. Gussen P (1977) Polyarteritis nodosa and deafness a human temporal bone study. Arch Otorhinolaryngol 217(3):263–271

    Article  CAS  PubMed  Google Scholar 

  14. Kornblut AD, Wolff SM, Fauci AS (1982) Ear disease in patients with Wegener’s granulomatosis. Laryngoscope 92(7 Pt 1):713–717

    Article  CAS  PubMed  Google Scholar 

  15. Trott MS, Hughes GB, Calabrese LH, Barna BP, Nodar RH (1996) Hearing and Sjögren’s syndrome. Ear Nose Throat J 75(10):666–668

    CAS  PubMed  Google Scholar 

  16. Hatzopoulos S, Amoroso C, Aimoni C, Lo Monaco A, Govoni M, Martini A (2002) Hearing loss evaluation of Sjögren’s syndrome using distortion product otoacoustic emissions. ActaOtolaryngol Suppl 548:20–25

    Google Scholar 

  17. Ziavra N, Politi EN, Kastanioudakis I, Skevas A, Drosos AA (2000) Hearing loss in Sjögren’s syndrome patients. A comparative study. Clin Exp Rheumatol 18(6):725–728

    CAS  PubMed  Google Scholar 

  18. Tumiati B, Casoli P (1995) Sudden sensorineural hearing loss and anticardiolipin antibody. Am J Otolaryngol 16(3):220

    Article  CAS  PubMed  Google Scholar 

  19. Ramos-Casals M, Brito-Zeron P, Yague J, Akasbi M, Bautista R, Ruano M et al (2005) Hypocomplementaemia as an immunological marker of morbidity and mortality in patients with primary Sjögren’s syndrome. Rheumatology 44(1):89–94

    Article  CAS  PubMed  Google Scholar 

  20. Katz J, Burkard RF (2002) Handbook of clinical audiology, 5th edn. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  21. Meena RS, Aseri Y, Singh BK, Verma PC (2012) Hearing loss in patients of chronic renal failure: a study of 100 cases. Indian J Otolaryngol Head Neck Surg 64(4):356–359

    Article  PubMed  Google Scholar 

  22. Bhumika N, Prabhu GV, Am Ferreira, Kulkarni MK (2013) Noise-induced hearing loss still a problem in shipbuilders: a cross-sectional study in Goa, India. Ann Med Health Sci Res 3(1):1–6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Doig JA, Whaley K, Dick WC, Nuki G, Williamson J, Buchanan WW (1971) Otolaryngological aspects of Sjögren’s syndrome. Br Med J 4(5785):460–463

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Boki KA, Ioannidis JP, Segas JV, Maragkoudakis PV, Petrou D, Adamopoulos GK et al (2001) How significant is sensorineural hearing loss in primary Sjögren’s syndrome? An individually matched case-control study. J Rheumatol 28(4):798–801

    CAS  PubMed  Google Scholar 

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Acknowledgments

The authors wish to thank the institutional review board for its financial support toward this study through the fluid research fund.

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Authors and Affiliations

  1. Department of ENT, Christian Medical College, Vellore, India

    C. V. Thanooja, Ann Mary Augustine, Anjali Lepcha, Amit Kumar Tyagi & Achamma Balraj

  2. Department of Rheumatology, Christian Medical College, Vellore, India

    Pulukool Sandhya & Debashish Danda

Authors
  1. C. V. Thanooja
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  2. Ann Mary Augustine
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  3. Anjali Lepcha
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  4. Pulukool Sandhya
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  5. Amit Kumar Tyagi
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  6. Debashish Danda
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  7. Achamma Balraj
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Corresponding author

Correspondence to Ann Mary Augustine.

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Conflict of interest

C. V. Thanooja, Ann Mary Augustine, Anjali Lepcha, Pulukool Sandhya, Amit Kumar Tyagi, Debashish Danda, Achamma Balraj declare that they have no conflict of interest.

Funding

This study was funded by a research grant from the institution.

Ethical Approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional review board and ethics committee and with the 1964 Helsinki declaration and its later amendments.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Thanooja, C.V., Augustine, A.M., Lepcha, A. et al. Audiological Profile in Primary Sjögren’s Syndrome in a Tertiary Care Setting and its Clinical Implications. Indian J Otolaryngol Head Neck Surg 70, 59–65 (2018). https://doi.org/10.1007/s12070-015-0956-y

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  • DOI: https://doi.org/10.1007/s12070-015-0956-y

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