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Varied manifestations of Rosai-Dorfman disease and its management — a case report and review of literature

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Rosai Dorfman disease or sinus histiocytosis is a rare, idiopathic, benign and self-limiting histiocytic proliferative disorder, usually seen in younger patients. It most commonly involves the cervical lymph nodes, with a predominant infiltration of sinusoidal histiocytes and classically presents with massive cervical lymhadenopathy. Extranodal disease occurs in about 43% of cases and produces different signs and symptoms depending upon its location. We report a case of this disorder in 22-year-old male with initial isolated involvement of bilateral nasal cavity and paranasal sinuses with subsequent involvement of cervical lymph nodes and skin. The clinical presentation, histologic characterstics, radiographic findings and treatment of the disease are discussed.

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References

  1. Rosai J, Dorfman RF (1969) Sinus histiocytosis with massive lymphadepathy: a newly recognized benign clinicopathologic entity. Arch Pathol 87:63–70

    PubMed  CAS  Google Scholar 

  2. Wenig BM, Abbondnzo SL, Childer EL et al (1993) Extranodal sinus histiocytosis with massive lymphadenopathy (Rosai Dorfman disease) of the head and neck. Hum Pathol 24:483–492

    Article  PubMed  CAS  Google Scholar 

  3. Annesi G, Gianneti A (1996) Purely cutaneous Rosai Dorfman disease. Br J Dermatol 134:749–753

    Article  Google Scholar 

  4. Goodnight JW, Wang MB, Secarz JA et al (1996) Extranodal Rosai Dorfman disease of head neck. Laryngoscope 106: 253–256

    Article  PubMed  CAS  Google Scholar 

  5. Peter KKM, Michael TCF, Leung CY et al (1999) Nasal manifestation of extranodal Rosai-Dorfman disease-diagnosis and management. J. Laryngol Otol 113:275–280

    Google Scholar 

  6. Gregor RT, Ninnin D (1994) Rosai Dorfman disease of the paranasal sinuses. J Laryngol Otol 108:152–155

    Article  PubMed  CAS  Google Scholar 

  7. Foucar E, Rosai J, Dorfman RF (1979) The ophthalmologic manifestations of sinus histiocytosis with massive lymphadenopathy. Am J Ophthalmol 87:354–367

    PubMed  CAS  Google Scholar 

  8. Foucar E, Rosai J, Dorfman RF (1978) Sinus histiocytosis with massive lymphadenopathy: Ear, nose and throat manifestations. Arch Otolaryngol Head Neck Surg 104: 687–693

    CAS  Google Scholar 

  9. Green I, Dorfman RF, Rosai J (1997) Breast involvement by extranodal Rosai-Dorfman disease: report of seven cases. Am. J. Surg Pathol 21:664–668

    Article  PubMed  CAS  Google Scholar 

  10. Resnick DK, John BL, Lovely TJ (1996) Rosai Dorfman disease presenting with multiple orbital and intracranial masses. Acta Neuropathologica 91:554–557

    Article  PubMed  CAS  Google Scholar 

  11. Paulli M, Rosso R, Kindl S, et al (1992) Immunophenotypic characterization of the cell infiltrate in five cases of sinus histiocytosis with massive lymphadenopathy (Rosai Dorfman disease). Hum Pathol 23:647–654

    Article  PubMed  CAS  Google Scholar 

  12. Sacchi S, Artusi T, Torelli U et al (1992) Sinus histiocytosis with massive lymphadenopathy. Leuk Lymphoma 23: 647–654

    Google Scholar 

  13. Wright DH, Richards DB (1981) Sinus histiocytosis with massive lymphadenopathy (Rosai Dorfman disease): Report of a case with widespread nodal and extranodal dissemination. Histopathology 5(6):697–709

    Article  PubMed  CAS  Google Scholar 

  14. Eisen RN, Backley PJ, Howard DJ (1990) Immunophenotypic characterization of sinus histiocytosis with massive lymphadenopathy(Rosai-Dorfman disease). Semin Diagn Pathol 7:74–82

    PubMed  CAS  Google Scholar 

  15. McAlister WH, Herman T, Dehner LP (1990) Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Pediatr Radiol 20:425–432

    Article  PubMed  CAS  Google Scholar 

  16. Komp DM (1990) The treatment of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Semin Diagn Pathol 7:83–86

    PubMed  CAS  Google Scholar 

  17. Jabali Y, Smrcka V, Pradna J (2005) Rosai-Dorfman disease: successful long-term results by combination chemotherapy with prednisone, 6-mercaptopurine, methotrexate, and vinblastine: a case report. Int J Surg Pathol 13:285–9

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Otorhinolaryngology and Head and Neck Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India

    Pradipta Kumar Parida & Naresh K. Panda

  2. Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India

    Aman sharma

  3. Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India

    V. Mahesha & Ashim Das

Authors
  1. Pradipta Kumar Parida
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  2. Naresh K. Panda
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  3. Aman sharma
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  4. V. Mahesha
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  5. Ashim Das
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Correspondence to Naresh K. Panda.

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Parida, P.K., Panda, N.K., sharma, A. et al. Varied manifestations of Rosai-Dorfman disease and its management — a case report and review of literature. Indian J Otolaryngol Head Neck S 60, 365–368 (2008). https://doi.org/10.1007/s12070-008-0117-7

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  • DOI: https://doi.org/10.1007/s12070-008-0117-7

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