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Head and Neck Squamous Cell Cancer: Biology (II) and Translational Methods

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

The essential steps implicated in carcinogenesis are acquisition of autonomous proliferative signaling; inhibition of growth inhibitory signals; evasion of apoptosis; immortalization; angiogenesis; tissue invasion and metastasis. A considerable progress in understanding the process of carcinogenesis has further stimulated the high throughput translational methods and systems biology approach to revolutionize this field of cancer biology. The era of molecular targeted therapy has dawned and would soon replace the more ‘toxic’ classical ‘broad-spectrum’ cancer chemotherapy. This review summarises the steps of carcinogenesis and the concepts involved in translational methods, systems-biology and molecular targeted therapy.

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Author information

Author notes

  1. Xiaolin Nong

    Present address: , A-1/ 19, sector H, Aliganj, Lucknow (UP), India

Authors and Affiliations

  1. Department of Head and Neck Surgery, UT MD Anderson Cancer center, Houston, USA

    Anupam Mishra

  2. Department of Obstetrics and Gynaecology, K.G. Medical University, Lucknow, India

    Amita Pandey

  3. Oral and Maxillofacial Surgery, Guangxi Medical University, Guangxi, China

    Xiaolin Nong

Authors
  1. Anupam Mishra
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  2. Amita Pandey
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  3. Xiaolin Nong
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Correspondence to Anupam Mishra.

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Mishra, A., Pandey, A. & Nong, X. Head and Neck Squamous Cell Cancer: Biology (II) and Translational Methods. Indian J Otolaryngol Head Neck S 59, 245–251 (2007). https://doi.org/10.1007/s12070-007-0071-9

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  • DOI: https://doi.org/10.1007/s12070-007-0071-9

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