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Biologic Basis of Personalized Therapy in Head and Neck Squamous Cell Carcinoma

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Contemporary Oral Oncology

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the 7th most common cancer worldwide, with more than 500,000 new cases each year [1]. HNSCCs are associated with a 5-year overall survival of approximately 50 % which has remained largely unchanged [2]. Cetuximab is the only FDA-approved targeted therapy for HNSCC and there are no clinically used biomarkers for HNSCC. Personalized therapy, treatment management customized to individual patient profile, is now being investigated with greater emphasis on the molecular profile of the patients, in addition to their clinical and pathological status. With the stagnant 5-year overall survival, this shift toward molecular integration is definitely warranted. Molecular profiling has the ability to categorize the patients based on effective treatment modality, treatment response and susceptibility to develop metastasis, thereby delineating the prognosis more accurately. Response assessment further enables selection of drugs based on the status of the targeted pathways, hence ensuring better treatment outcome. Nevertheless, the success of this approach is dependent on the selection of appropriate biomarkers. Differences in the biology of cancers in terms of characteristics such as site, tissue of origin, and etiology make it mandatory to catalog the changes that are specific to each cancer as a step toward the personalized medicine approach. The advent of high-throughput techniques has enabled a global view of the molecular changes that occur at every level and hence are arguably the best option to understand and identify the probable clinically relevant and targetable pathways in HNSCC.

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Authors and Affiliations

  1. Strand Life Sciences Pvt. Ltd., Bangalore, India

    Pramila Tata, Kalyanasundaram Subramaniayan, Vaijayanti Gupta & Urvashi Bahadur

  2. Integrated Head and Neck Oncology Program, Mazumdar Shaw Center for Translational Research (MSCTR), MSMF, Bangalore, India

    Amritha Suresh

  3. University of Chicago, Chicago, IL, USA

    Nishant Agrawal

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  1. Pramila Tata
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  4. Vaijayanti Gupta
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Correspondence to Pramila Tata .

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  1. Department of Head and Neck, Plastic and Reconstructive Surgery, Roswell Park Cancer Institute, Buffalo, USA

    Moni Abraham Kuriakose

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Tata, P., Subramaniayan, K., Suresh, A., Gupta, V., Bahadur, U., Agrawal, N. (2017). Biologic Basis of Personalized Therapy in Head and Neck Squamous Cell Carcinoma. In: Kuriakose, M.A. (eds) Contemporary Oral Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-14911-0_12

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