Abstract
The immune system protects our bodies against infections and cancers. This review introduce readers to the thymus – a primary lymphoid organ – which is the site of development and maturation of functional T lymphocytes. Progenitor stem cells arise from the bone marrow and undergo sequential development in the thymus where non-self-reactive T cells are selected. Subsequently, post selection and maturation, the mature T cells exit the thymus as naïve T cells into the peripheral lymph nodes. Studies on the thymus are likely to enhance our understanding of T cell development and reduce disease burdens by improving the cellular immune response.
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M Deobagkar-Lele, C Bhaskarla, R Dhanaraju, M Ponnusamy, D Nandi, Innate immunity and the 2011 Nobel Prize, Resonance, Vol.17, No.10 pp.974–995, 2012.
A Ahmed, B Saha, A Patwardhan, S Shivaprasad, D Nandi, The Major Players in Adaptive Immunity–Humoral Immunity, Resonance, Vol.14, No.5 pp.455–471, 2009.
A Ahmed, B Saha, A Patwardhan, S Shivaprasad, D Nandi, The Major Players in Adaptive Immunity 1. Cell-mediated Immunity, Resonance, Vol.14, No.6 pp.610–621, 2009.
G Anderson, Y Takahama, Thymic Epithelial Cells: Working Class Heroes for T cell Development and Repertoire Selection, Trends Immunol., Vol.33, pp.256–63, 2012.
J F Miller, Immunological Function of the Thymus, Lancet, Vol.2, pp.748–9, 1961.
J F Miller, D Osoba, Current Concepts of the Immunological Function of the Thymus, Physiol Rev., Vol.47, pp.437–520, 1967.
L Westera, J Drylewicz, I den Braber, T Mugwagwa, I van der Maas, L Kwast, T Volman, E H van de Weg-Schrijver, I Bartha, G Spierenburg, K Gaiser, M T Ackermans, B Asquith, R J de Boer, K Tesselaar, J A Borghans, Closing the Gap Between T-cell Life Span Estimates From Stable Isotopelabeling Studies in Mice and Humans, Blood, 122, pp.2205–12, 2013.
L Klein, B Kyewski, P M Allen, K A Hogquist, Positive and Negative Selection of the T cell Repertoire: What Thymocytes See (and Don’t Dee), Nat Rev Immunol, Vol.14, pp.377–91, 2014.
G Anderson, E J Jenkinson, Fetal Thymus Organ Culture, CSH Protoc., pdb.prot4808.
W Savino, D A Mendes-da-Cruz, A Lepletier, M Dardenne, Hormonal Control of T-cell Development in Health and Disease, Nat Rev Endocrinol., Vol.12, 77–89, 2016.
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1 Shamik and 2 Sanmoy are research scholars studying T cell immunity. Dipankar Nandi is a Professor in the Biochemistry Department of the Indian Institute of Science, Bangalore.
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Majumdar, S., Pathak, S. & Nandi, D. Thymus. Reson 23, 197–217 (2018). https://doi.org/10.1007/s12045-018-0605-3
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DOI: https://doi.org/10.1007/s12045-018-0605-3