Abstract
Self-assembling behaviour of block copolymers and their ability to evade the immune system through polyethylene oxide stealth makes it an attractive candidate for drug encapsulation. Micelles formed by polyethylene oxide-polypropylene oxide- polyethylene oxide triblock copolymers (PEO-PPO-PEO), pluronic P123, have been employed for encapsulating the anti-cancer drug doxorubicin hydrochloride. The binding affinity of doxorubicin within the micelle carrier is enhanced through complex formation of drug and anionic surfactant, aerosol OT (AOT). Electrostatic binding of doxorubicin with negatively charged surfactants leads to the formation of hydrophobic drug-surfactant complexes. Surfactant-induced partitioning of the anti-cancer drug into nonpolar solvents such as chloroform is investigated. SANS measurements were performed on pluronic P123 micelles in the presence of drug-surfactant complex. No significant changes in the structure of the micelles are observed upon drug encapsulation. This demonstrates that surfactant- drug complexes can be encapsulated in block copolymer micelles without disrupting the structure of aggregates.
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References
C de Verdiere, C Dubernet, F Nemati, M F Poupon, F Puisieux and P Couvreur, Cancer Chemother. Pharmacol. 33, 504 (1994)
G S Kwon and K Kataoka, Adv. Drug Delive. Rev. 16, 295 (1995)
Hyuk Sang Yoo, Eun Ah Lee and Tae Gwan Park, J. Control Release 82, 17 (2002)
Tatiana K Bronich, Andrew Nehls, Adi Eisenberg, Victor A Kabanov and Alexander V Kabanov, Colloids and Surfaces B16, 243 (1999)
K Kataoka, T Matsumoto, M Yokoyama, T Okano, Y Sakurai, S Fukushima, K Okamota and G S Kwon, J. Control Release 64, 143 (2000)
Yuan Tian, Palaniswamy Ravi, T Alan Hatton and Kam C Tam, Langmuir 23, 2638 (2007)
J S Pedersen, J. Appl. Crystallogr. 33, 637 (2000)
R Ganguly, V K Aswal and P A Hassan, J. Colloid Interface Sci. 315, 693 (2007)
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Bhattacharjee, J., Verma, G., Aswal, V.K. et al. Small angle neutron scattering study of doxorubicin-surfactant complexes encapsulated in block copolymer micelles. Pramana - J Phys 71, 991–995 (2008). https://doi.org/10.1007/s12043-008-0212-z
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DOI: https://doi.org/10.1007/s12043-008-0212-z