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Interaction, solubilization and location of p-hydroxybenzoic acid and its sodium salt in micelles of moderately hydrophilic PEO-PPO-PEO triblock copolymers

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Abstract

Micelles of ABA type triblock copolymers (where A is polyethylene oxide PEO and B is polypropylene oxide PPO) viz. Pluronic® P103, P104 and P105 (each containing almost the same PPO mol wt. ∼ 3250 g/mol and 30, 40 and 50 wt.% of PEO, respectively) in the presence of p -hydroxybenzoic acid (PHBA) and its sodium salt (Na-PHBA) were examined by viscosity, dynamic light scattering (DLS), small angle neutron scattering (SANS) and NMR. Spherical polymeric micelles (apparent hydrodynamic diameter ∼ 20 nm) in water at 30 ° C grow in the presence of PHBA and transform into prolate-ellipsoidal shape with an increased aggregation number. The micellar transition was favored at higher PHBA concentration, temperature and for copolymers with more hydrophobicity. The PHBA salt, however, increased cloud point and showed only a marginal decrease in aggregation number even at much higher concentrations. The location of PHBA in micelle was elucidated by nuclear Overhauser enhancement spectroscopy (NOESY).

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References

  1. P. Alexandridis, B. Lindman, Amphiphilic Block Copolymers: Self-Assembly and Applications (Elsevier, 2000).

  2. K. Devanand, J. Selser, Nature 343, 739 (1990).

    Article  ADS  Google Scholar 

  3. G. Wanka, H. Hoffmann, W. Ulbricht, Macromolecules 27, 4145 (1994).

    Article  ADS  Google Scholar 

  4. B. Chu, Z. Zhou, Physical Chemistry of Polyoxyalkylene Block Copolymer Surfactants (CRC Press, 1996).

  5. G. Dumortier, J.L. Grossiord, F. Agnely, J.C. Chaumeil, Pharm. Res. 23, 2709 (2006).

    Article  Google Scholar 

  6. R. Ivanova, B. Lindman, P. Alexandridis, Adv. Colloid Interface Sci. 89, 351 (2001).

    Article  Google Scholar 

  7. P. Alexandridis, U. Olsson, B. Lindman, Langmuir 14, 2627 (1998).

    Article  Google Scholar 

  8. J. Zipfel, J. Berghausen, G. Schmidt, P. Lindner, P. Alexandridis, M. Tsianou, W. Richtering, Phys. Chem. Chem. Phys. 1, 3905 (1999).

    Article  Google Scholar 

  9. R. Ganguly, M. Kumbhakar, V. Aswal, J. Phys. Chem. B 113, 9441 (2009).

    Article  Google Scholar 

  10. Y. Kadam, R. Ganguly, M. Kumbhakar, V.K. Aswal, P.A. Hassan, P. Bahadur, J. Phys. Chem. B 113, 16296 (2009).

    Article  Google Scholar 

  11. P. Alexandridis, V. Athanassiou, S. Fukuda, T.A. Hatton, Langmuir 10, 2604 (1994).

    Article  Google Scholar 

  12. G. Riess, J. Nervo, D. Rogez, Polym. Eng. Sci. 17, 634 (1977).

    Article  Google Scholar 

  13. J. Horský, Z. Walterova, Colloid. Polym. Sci. 283, 1033 (2005).

    Article  Google Scholar 

  14. P. Yang, D. Zhao, D.I. Margolese, B.F. Chmelka, G.D. Stucky, Nature 396, 152 (1998).

    Article  ADS  Google Scholar 

  15. K. Flodström, V. Alfredsson, Microporous Mesoporous Mater. 59, 167 (2003).

    Article  Google Scholar 

  16. P. Alexandridis, M. Tsianou, Eur. Polym. J. 47, 569 (2011).

    Article  Google Scholar 

  17. M.S. Bakshi, A. Kaura, P. Bhandari, G. Kaur, K. Torigoe, K. Esumi, J. Nanosci. Nanotechnol. 6, 1405 (2006).

    Article  Google Scholar 

  18. A.V. Kabanov, E.V. Batrakova, V.Y. Alakhov, Adv. Drug Delivery Rev. 54, 759 (2002).

    Article  Google Scholar 

  19. K. Kataoka, A. Harada, Y. Nagasaki, Adv. Drug Delivery Rev. 47, 113 (2001).

    Article  Google Scholar 

  20. L. Heerema, D. Cakali, M. Roelands, E. Goetheer, D. Verdoes, J. Keurentjes, Sep. Purif. Technol. 74, 55 (2010).

    Article  Google Scholar 

  21. L. Heerema, D. Cakali, M. Roelands, E. Goetheer, D. Verdoes, J. Keurentjes, Sep. Purif. Technol. 73, 319 (2010).

    Article  Google Scholar 

  22. P. Alexandridis, L. Yang, Macromolecules 33, 5574 (2000).

    Article  ADS  Google Scholar 

  23. J. Mata, P. Majhi, O. Kubota, A. Khanal, K. Nakashima, P. Bahadur, J. Colloid Interface Sci. 320, 275 (2008).

    Article  Google Scholar 

  24. R. Ganguly, K. Kuperkar, P. Parekh, V. Aswal, P. Bahadur, J. Colloid Interface Sci. 378, 118 (2012).

    Article  Google Scholar 

  25. J. Armstrong, B. Chowdhry, J. Mitchell, A. Beezer, S. Leharne, J. Phys. Chem. 100, 1738 (1996).

    Article  Google Scholar 

  26. A. Parmar, K. Singh, A. Bahadur, G. Marangoni, P. Bahadur, Colloids Surf. B 86, 319 (2011).

    Article  Google Scholar 

  27. M. Donbrow, C. Rhodes, J. Pharm. Pharmacol. 18, 424 (1966).

    Article  Google Scholar 

  28. P. Mukerjee, J. Pharm. Sci. 60, 1528 (1971).

    Article  Google Scholar 

  29. A. Heins, D.B. McPhail, T. Sokolowski, H. Stöckmann, K. Schwarz, Lipids 42, 573 (2007).

    Article  Google Scholar 

  30. M. Khimani, R. Ganguly, V. Aswal, S. Nath, P. Bahadur, J. Phys. Chem. B 116, 14943 (2012).

    Article  Google Scholar 

  31. V. Aswal, P. Goyal, Curr. Sci. 79, 947 (2000).

    Google Scholar 

  32. J. Hayter, J. Penfold, Colloid Polym. Sci. 261, 1022 (1983).

    Article  Google Scholar 

  33. J.B. Hayter, J. Penfold, J. Chem. Soc., Faraday Trans. 1 77, 1851 (1981).

    Article  Google Scholar 

  34. J.B. Hayter, J. Penfold, Mol. Phys. 42, 109 (1981).

    Article  ADS  Google Scholar 

  35. J.-P. Hansen, J.B. Hayter, Mol. Phys. 46, 651 (1982).

    Article  ADS  Google Scholar 

  36. S.-H. Chen, Annu. Rev. Phys. Chem 37, 351 (1986).

    Article  ADS  Google Scholar 

  37. S.-H. Chen, T.-L. Lin, Methods Exp. Phys. 23, 489 (1987).

    Article  ADS  Google Scholar 

  38. R.C.d. Silva, W. Loh, J. Colloid Interface Sci. 202, 385 (1998).

    Article  Google Scholar 

  39. Y. Zhang, P.S. Cremer, Curr. Opin. Chem. Biol. 10, 658 (2006).

    Article  Google Scholar 

  40. Y. Zhang, S. Furyk, D.E. Bergbreiter, P.S. Cremer, J. Am. Chem. Soc. 127, 14505 (2005).

    Article  Google Scholar 

  41. G. Waton, B. Michels, R. Zana, J. Colloid Interface Sci. 212, 593 (1999).

    Article  Google Scholar 

  42. M.J. Kositza, C. Bohne, P. Alexandridis, T.A. Hatton, J.F. Holzwarth, Langmuir 15, 322 (1999).

    Article  Google Scholar 

  43. M. Prasad, S. Moulik, D. Chisholm, R. Palepu, J. Oleo Sci. 52, 523 (2003).

    Article  Google Scholar 

  44. A. Klaus, G.J. Tiddy, R. Rachel, A.P. Trinh, E. Maurer, D. Touraud, W. Kunz, Langmuir 27, 4403 (2011).

    Article  Google Scholar 

  45. R. Sharma, P. Bahadur, J. Surfactants Deterg. 5, 263 (2002).

    Article  Google Scholar 

  46. A. Shaheen, N. Kaur, R.K. Mahajan, Colloid Polym. Sci. 286, 319 (2008).

    Article  Google Scholar 

  47. Y.P. Saraf, S.S. Bhagwat, Sep. Technol. 5, 207 (1995).

    Article  Google Scholar 

  48. W.A. Pryor, J.A. Cornicelli, L.J. Devall, B. Tait, B. Trivedi, D. Witiak, M. Wu, J. Org. Chem. 58, 3521 (1993).

    Article  Google Scholar 

  49. L. Guo, R.H. Colby, P. Thiyagarajan, Physica B: Condens. Matter 385, 685 (2006).

    Article  ADS  Google Scholar 

  50. I. Goldmints, F.K. von Gottberg, K.A. Smith, T.A. Hatton, Langmuir 13, 3659 (1997).

    Article  Google Scholar 

  51. P. Alexandridis, T. Nivaggioli, T.A. Hatton, Langmuir 11, 1468 (1995).

    Article  Google Scholar 

  52. F. Li, L.H.J. de Haan, A.T.M. Marcelis, F.A.M. Leermakers, M.A.C. Stuart, E.J.R. Sudhölter, Soft Matter 5, 4042 (2009).

    Article  ADS  Google Scholar 

  53. N. Jain, V. Aswal, P. Goyal, P. Bahadur, Colloids Surf. A 173, 85 (2000).

    Article  Google Scholar 

  54. B. Foster, T. Cosgrove, B. Hammouda, Langmuir 25, 6760 (2009).

    Article  Google Scholar 

  55. G. Wanka, H. Hoffmann, W. Ulbricht, Colloid Polym. Sci. 268, 101 (1990).

    Article  Google Scholar 

  56. R. Nagarajan, Colloids Surf. B 16, 55 (1999).

    Article  Google Scholar 

  57. P. Parekh, K. Singh, D.G. Marangoni, V.K. Aswal, P. Bahadur, J. Surfactants Deterg. 15, 1 (2012).

    Article  Google Scholar 

  58. J. Ma, C. Guo, Y. Tang, J. Wang, L. Zheng, X. Liang, S. Chen, H. Liu, Langmuir 23, 3075 (2007).

    Article  Google Scholar 

  59. X. Liang, C. Guo, J. Ma, J. Wang, S. Chen, H. Liu, J. Phys. Chem. B 111, 13217 (2007).

    Article  Google Scholar 

  60. J. Ma, C. Guo, Y. Tang, H. Liu, Langmuir 23, 9596 (2007).

    Article  Google Scholar 

  61. D.L. Pavia, G.M. Lampman, G.S. Kriz, R.G. Engel, A Small-Scale Approach to Organic Laboratory Techniques (Cengage Learning, 2010).

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Authors and Affiliations

  1. Department of Chemistry, Veer Narmad South Gujarat University, 395 007, Surat, India

    Mehul Khimani, Paresh Parekh & Pratap Bahadur

  2. Solid State Physics Division, Bhabha Atomic Research Centre, 400 085, Mumbai, India

    Vinod K. Aswal

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  1. Mehul Khimani
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  2. Paresh Parekh
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  3. Vinod K. Aswal
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  4. Pratap Bahadur
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Correspondence to Mehul Khimani.

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Khimani, M., Parekh, P., Aswal, V.K. et al. Interaction, solubilization and location of p-hydroxybenzoic acid and its sodium salt in micelles of moderately hydrophilic PEO-PPO-PEO triblock copolymers. Eur. Phys. J. E 37, 38 (2014). https://doi.org/10.1140/epje/i2014-14038-9

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