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Association of lncRNA PRNCR1 polymorphisms with cancer susceptibility: a meta-analysis of the current literature

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Abstract

Considerable studies exploring the relevance of single-nucleotide polymorphisms (SNPs) in the prostate cancer noncoding RNA 1 (PRNCR1) gene with various cancer susceptibilities have obtained debatable results. This meta-analysis was performed to precisely assess this association. Relevant published studies were selected by retrieving studies from PubMed, Embase, Web of Science, CNKI and Chinese Wanfang databases. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were applied to evaluate the strength of PRNCR1 polymorphisms correlated with cancer susceptibility. A total of 12 articles, containing 40 independent case–control studies and seven SNPs (rs1016343, rs13252298, rs16901946, rs7007694, rs1456315, rs13254738 and rs7463708), were ultimately included in our meta-analysis. Summary results revealed a significant association with an increased overall risk of cancer for the rs1016343 C>T polymorphism (T vs C: OR=1.19, 95% CI=1.02–1.39; TT+CT vs CC: OR= 1.25, 95% CI=1.05–1.49) and rs16901946 A>G polymorphism (G vs A: OR=1.17, 95% CI=1.09–1.27; GG+AG vs AA: OR=1.20, 95% CI=1.09–1.32). Moreover, evidence of the rs13252298 A>G polymorphism correlation with decreased overall risk of cancer was observed (GG vs AG+AA: OR=0.78, 95% CI =0.67–0.92). Subgroup analyses by cancer type and ethnicity also revealed that the rs1016343 C>T polymorphism was linked with an increased risk of prostate cancer and Caucasians, respectively. The rs13252298 A>G polymorphism was correlated with a decreased risk of colorectal cancer and prostate cancer. The rs16901946 A>G polymorphism was related to an increased risk of gastric cancer and colorectal cancer in Asians. Additionally, the rs13254738 A>C polymorphism was correlated with reduced cancer risk in Asians. No correlations were discovered with cancer risk in rs7007694 T>C, rs7463708 T>G, and rs1456315 A>G polymorphisms. In summary, our meta-analysis indicates that PRNCR1 rs1016343, rs16901946 and 13252298 polymorphisms are associated with cancer susceptibility. Further large-scale studies are required to certify our findings.

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Acknowledgments

We thank Luping Wang for providing help in data analysis.

Author information

Author notes

  1. YL and PD designed and drafted the manuscript; PD, GYL, JSZ, and YTL searched relevant articles and extracted data; PD, YYL, and NTF performed the data analyses. YL gave the final approval of the version to be submitted. All authors read and approved the final manuscript.

Authors and Affiliations

  1. Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, People’s Republic of China

    Peng Du, Guoyong Li, Jisheng Zhu & Yong Li

  2. Department of Daytime Inpatient Ward, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, People’s Republic of China

    Yuting Luo & Nantao Fu

Authors
  1. Peng Du
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  2. Guoyong Li
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  3. Jisheng Zhu
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  4. Yuting Luo
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  5. Nantao Fu
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  6. Yong Li
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Correspondence to Yong Li.

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Corresponding editor: Upendra Nongthomba

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Du, P., Li, G., Zhu, J. et al. Association of lncRNA PRNCR1 polymorphisms with cancer susceptibility: a meta-analysis of the current literature. J Genet 100, 19 (2021). https://doi.org/10.1007/s12041-021-01269-3

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  • DOI: https://doi.org/10.1007/s12041-021-01269-3

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