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Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of gastric cancer

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Tumor Biology

Abstract

A long ncRNA (lncRNA) prostate cancer non-coding RNA 1 (PRNCR1) in the 8q24 has been reported to be upregulated in prostate cancer with a function of activating androgen receptor (AR). AR plays a key role in the gender disparity, cell migration, and invasion of gastric cancer (GC). We hypothesized that single nucleotide polymorphisms (SNPs) in the lncRNA PRNCR1 may be related to the risk of GC. We conducted a case-control study to investigate the association between SNPs in the lncRNA PRNCR1 and the risk of GC. Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) assay was used to determine the genotypes of 613 subjects including 219 cases with GC and 394 controls. We found that patients with the rs13252298AG genotype displayed a 1.50-fold increased risk of GC (AG vs. AA, 95 % confidence interval (CI) = 1.05–2.12, p = 0.02). Interestingly, the rs7007694CT and CC and the rs1456315GG genotypes displayed a decreased risk of GC (rs7007694CT vs. TT, odds ratio (OR) = 0.68, 95 % CI = 0.48–0.97, p = 0.03; rs7007694CC vs. TT, OR = 0.36, 95 % CI = 0.13–0.97, p = 0.04; rs1456315GG vs. AA, OR = 0.30, 95 % CI = 0.13–0.70, p = 0.004, respectively). Our results suggest that SNPs in the lncRNA PRNCR1 may be a biomarker for the etiology of GC.

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References

  1. Gonzalez CA, Sala N, Rokkas T. Gastric cancer: epidemiologic aspects. Helicobacter. 2013;18:34–8.

    Article  PubMed  Google Scholar 

  2. Jakszyn P, Gonzalez CA. Nitrosamine and related food intake and gastric and oesophageal cancer risk: a systematic review of the epidemiological evidence. World J Gastroenterol WJG. 2006;12:4296–303.

    Article  CAS  PubMed  Google Scholar 

  3. Lee HJ, Yang HK, Ahn YO. Gastric cancer in Korea. Gastr Cancer Off J Int Gastr Cancer Assoc Japan Gastr Cancer Assoc. 2002;5:177–82.

    Google Scholar 

  4. Li L, Feng T, Lian Y, Zhang G, Garen A, Song X. Role of human noncoding RNAs in the control of tumorigenesis. Proc Natl Acad Sci U S A. 2009;106:12956–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Zhang X, Rice K, Wang Y, Chen W, Zhong Y, Nakayama Y, et al. Maternally expressed gene 3 (MEG3) noncoding ribonucleic acid: isoform structure, expression, and functions. Endocrinology. 2010;151:939–47.

    Article  CAS  PubMed  Google Scholar 

  6. Pibouin L, Villaudy J, Ferbus D, Muleris M, Prosperi MT, Remvikos Y, et al. Cloning of the mRNA of overexpression in colon carcinoma-1: a sequence overexpressed in a subset of colon carcinomas. Cancer Genet Cytogenet. 2002;133:55–60.

    Article  CAS  PubMed  Google Scholar 

  7. Fu X, Ravindranath L, Tran N, Petrovics G, Srivastava S. Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1. DNA Cell Biol. 2006;25:135–41.

    Article  PubMed  Google Scholar 

  8. Calin GA, Liu CG, Ferracin M, Hyslop T, Spizzo R, Sevignani C, et al. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell. 2007;12:215–29.

    Article  CAS  PubMed  Google Scholar 

  9. Lin R, Maeda S, Liu C, Karin M, Edgington TS. A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene. 2007;26:851–8.

    Article  CAS  PubMed  Google Scholar 

  10. Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z, Sharpless NE. Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. PLoS Genet. 2010;6:e1001233.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Chung S, Nakagawa H, Uemura M, Piao L, Ashikawa K, Hosono N, et al. Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility. Cancer Sci. 2011;102:245–52.

    Article  CAS  PubMed  Google Scholar 

  12. Lochhead P, Ng MT, Hold GL, Rabkin CS, Vaughan TL, Gammon MD, et al. Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer. Eur J Cancer Prev. 2011;20:54–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Guo Y, Fang J, Liu Y, Sheng HH, Zhang XY, Chai HN, et al. Association between polymorphism rs6983267 and gastric cancer risk in Chinese population. World J Gastroenterol. 2011;17:1759–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Wu CW, Chi CW, Chang TJ, Lui WY, P'Eng FK. Sex hormone receptors in gastric cancer. Cancer-Am Cancer Soc. 1990;65:1396–400.

    CAS  Google Scholar 

  15. Iushkov PV. Sex hormone receptors in the gastric mucosa in gastric precancer and cancer. Arkh Patol. 1997;59:24–7.

    CAS  PubMed  Google Scholar 

  16. Polimeno L, Silecchia G, Spaziani E, Scucchi A, Dell'Aquila P, Ierardi E, et al. Estrogens, androgens, and EGF receptor expression in gastric carcinoma induced by N-methyl-N′-nitro-N-nitrosoguanidine. Dig Dis Sci. 1994;39:635–40.

    Article  CAS  PubMed  Google Scholar 

  17. Matsui M, Kojima O, Kawakami S, Uehara Y, Takahashi T. The prognosis of patients with gastric cancer possessing sex hormone receptors. Surg Today. 1992;22:421–5.

    Article  CAS  PubMed  Google Scholar 

  18. Kominea A, Konstantinopoulos PA, Kapranos N, Vandoros G, Gkermpesi M, Andricopoulos P, et al. Androgen receptor (AR) expression is an independent unfavorable prognostic factor in gastric cancer. J Cancer Res Clin Oncol. 2004;130:253–8.

    Article  CAS  PubMed  Google Scholar 

  19. Miyamoto H, Yang Z, Chen YT, Ishiguro H, Uemura H, Kubota Y, et al. Promotion of bladder cancer development and progression by androgen receptor signals. J Natl Cancer Inst. 2007;99:558–68.

    Article  CAS  PubMed  Google Scholar 

  20. Fang Z, Zhang T, Dizeyi N, Chen S, Wang H, Swanson KD, et al. Androgen receptor enhances p27 degradation in prostate cancer cells through rapid and selective TORC2 activation. J Biol Chem. 2012;287:2090–8.

    Article  CAS  PubMed  Google Scholar 

  21. Li LJ, Sun RF, Liang YD, Pan XM, Li ZH, Bai P, Zeng XF, Zhang DX, Zhang L, and Gao LB. Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer. J Exp Clin Canc Res. 2013;32.

  22. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, et al. The transcriptional landscape of the mammalian genome. Science. 2005;309:1559–63.

    Article  CAS  PubMed  Google Scholar 

  23. Zaratiegui M, Irvine DV, Martienssen RA. Noncoding RNAs and gene silencing. Cell. 2007;128:763–76.

    Article  CAS  PubMed  Google Scholar 

  24. Mercer TR, Dinger ME, Mattick JS. Long non-coding RNAs: insights into functions. Nat Rev Genet. 2009;10:155–9.

    Article  CAS  PubMed  Google Scholar 

  25. Costa FF. Non-coding RNAs: Meet thy masters. BioEssays: news and reviews in molecular, cellular and developmental biology. 2010;32:599–608

  26. Orom UA, Derrien T, Beringer M, Gumireddy K, Gardini A, Bussotti G, et al. Long noncoding RNAs with enhancer-like function in human cells. Cell. 2010;143:46–58.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Yang PK, Kuroda MI. Noncoding RNAs and intranuclear positioning in monoallelic gene expression. Cell. 2007;128:777–86.

    Article  CAS  PubMed  Google Scholar 

  28. Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 2010;464:1071–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Gong C, Maquat LE. lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements. Nature. 2011;470:284–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Zhao Y, Guo Q, Chen J, Hu J, Wang S, Sun Y. Role of long non-coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer: a clinical and in vitro investigation. Oncol Rep. 2014;31:358–64.

    CAS  PubMed  Google Scholar 

  31. Zhang EB, Kong R, Yin DD, You LH, Sun M, Han L, et al. Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a. Oncotarget. 2014;5:2276–92.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Zhang EB, Han L, Yin DD, Kong R, De W, Chen J. c-Myc-induced, long, noncoding H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer. Med Oncol. 2014;31:914.

    Article  PubMed  Google Scholar 

  33. Sun M, Jin FY, Xia R, Kong R, Li JH, Xu TP, et al. Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer. BMC Cancer. 2014;14:319.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Heemers HV, Tindall DJ. Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex. Endocr Rev. 2007;28:778–808.

    Article  CAS  PubMed  Google Scholar 

  35. Tian Y, Wan H, Lin Y, Xie X, Li Z, Tan G. Androgen receptor may be responsible for gender disparity in gastric cancer. Med Hypotheses. 2013;80:672–4.

    Article  CAS  PubMed  Google Scholar 

  36. Zhang BG, Du T, Zang MD, Chang Q, Fan ZY, Li JF, et al. Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9. Oncotarget. 2014

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (no. 81302149 and 81202387), Distinguished Young Scientist of Sichuan University (no. 2013SCU04A38), the Science and Technology Pillar Program of Sichuan Province (2014KJT059-2014SZ0001), and the PhD Programs Foundation of the Ministry of Education of China (no. 20130181120011).

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Authors and Affiliations

  1. Department of Forensic Medicine, Medical College of Soochow University, Suzhou, 215123, Jiangsu, People’s Republic of China

    Lijuan Li

  2. Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of China

    Lijuan Li, Yundan Liang, Ruifen Sun, Fang Yuan, Lin Zhang & Linbo Gao

  3. Department of Orthopedics, National Clinical Key Specialty, Yanan Hospital, Kunming Medical University, Kunming, 650051, Yunnan, People’s Republic of China

    Fu Jia

  4. Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of China

    Peng Bai

  5. Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of China

    Lin Zhang & Linbo Gao

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  1. Lijuan Li
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Correspondence to Lin Zhang or Linbo Gao.

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Li, L., Jia, F., Bai, P. et al. Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of gastric cancer. Tumor Biol. 37, 299–303 (2016). https://doi.org/10.1007/s13277-015-3750-2

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  • DOI: https://doi.org/10.1007/s13277-015-3750-2

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