Skip to main content
SpringerLink
Log in

Association between KIAA0319 SNPs and risk of dyslexia: a meta-analysis

  • Research Note
  • Published:
Journal of Genetics Aims and scope Submit manuscript

Abstract

The aetiology of developmental dyslexia (DD) is complex; although candidate genes have been suggested, the molecular mechanism and risk factors remain unknown. The KIAA0319 gene is functionally related to neuronal migration and axon growth, and several studies have examined associations between KIAA0319 polymorphisms with DD, but the results remain inconsistent. The sample size affects the results of meta-analysis. The aim of this meta-analysis was to clarify the effect of KIAA0319 polymorphisms on dyslexia susceptibility according to the available evidence. All eligible case–control and transmission/disequilibrium test (TDT) studies published until March 2018 were identified by searching Medline, PubMed, Embase, Web of Science and Chinese Biomedical Database, limited to Chinese and English language papers. Pooled odds ratios and 95% confidence intervals were calculated using STATS package v12.0. A total of 11 related studies, including 3130 cases of dyslexia and 3460 healthy control subjects, as well as four TDT studies with 842 families were included in our meta-analysis. The results indicated that the polymorphisms rs4504469, rs2038137, rs2179515, rs3212236, rs6935076, rs9461045, rs2143340 and rs761100 have no association between the polymorphisms and dyslexia risk. Three subgroup meta-analyses were performed according to the study design, country and population. The stratified analysis revealed that the KIAA0319 rs4504469 minor allele was a risk allele t in the TDT subgroup, rs3212236 minor allele was a risk allele t in the UK subgroup and rs6935076 minor allele was a risk allele t in the Canada subgroup. Further studies with larger sample sizes that assess gene–gene and gene–environment interactions are required. The sample size of our study is larger than that of the previous studies, and the results are different from those of the previous studies. We have synthesized all the current studies on KIAA0319 and obtained reliable results.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  • Becker N., Vasconcelos M., Oliveira V., Santos F. C. D., Bizarro L., Almeida R. M. M. et al. 2017 Genetic and environmental risk factors for developmental dyslexia in children: systematic review of the last decade. Dev. Neuropsychol. 42, 423–445.

    Article  Google Scholar 

  • Brkanac Z., Chapman N. H., Matsushita M. M., Chun L., Nielsen K., Cochrane E. et al. 2007 Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B, 556–560.

    Article  CAS  Google Scholar 

  • Centanni T. M., Booker A. B., Sloan A. M., Chen F., Maher B. J., Carraway R. S. et al. 2014 Knockdown of the dyslexia-associated gene KIAA0319 impairs temporal responses to speech stimuli in rat primary auditory cortex. Cereb. Cortex 24, 1753–1766.

    Article  CAS  Google Scholar 

  • Cope N., Harold D., Hill G., Moskvina V., Stevenson J., Holmans P. et al. 2005 Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. Am. J. Hum. Genet. 76, 581–591.

    Article  CAS  Google Scholar 

  • Couto J. M., Livne-Bar I., Huang K., Xu Z., Cate-Carter T., Feng Y. et al. 2010 Association of reading disabilities with regions marked by acetylated H3 histones in KIAA0319. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B, 447–462.

    Article  CAS  Google Scholar 

  • Darki F., Peyrard-Janvid M., Matsson H., Kere J. and Klingberg T. 2012 Three dyslexia susceptibility genes, DYX1C1, DCDC2, and KIAA0319, affect temporo-parietal white matter structure. Biol. Psychiatry 72, 671–676.

    Article  CAS  Google Scholar 

  • Dennis M. Y., Paracchini S., Scerri T. S., Prokunina-Olsson L., Knight J. C., Wade-Martins R. et al. 2009 A common variant associated with dyslexia reduces expression of the KIAA0319 gene. PLoS Genet. 5, 135–139.

    Article  Google Scholar 

  • Francks C., Paracchini S., Smith S. D., Richardson A. J., Scerri T. S., Cardon L. R. et al. 2004 A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. Am. J. Hum. Genet. 75, 1046–1058.

    Article  CAS  Google Scholar 

  • Harold D., Paracchini S., Scerri T., Dennis M., Cope N., Hill G. et al. 2006 Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia. Mol. Psychiatry 11, 1085–1091.

    Article  CAS  Google Scholar 

  • Kaplan D. E., Gayan J., Ahn J., Won T. W., Pauls D., Olson R. K. et al. 2002 Evidence for linkage and association with reading disability on 6p21.3-22. Am. J. Hum. Genet. 70, 1287–1298.

    Article  CAS  Google Scholar 

  • Kazeem G. R. and Farrall M. 2005 Integrating care-control and TDT studies. Ann. Hum. Genet. 69, 329–335.

    Article  CAS  Google Scholar 

  • Ludwig K. U., Roeske D., Schumacher J., Schulte-Körne G., König I. R., Warnke A. et al. 2008 Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample. J. Neural. Transm. 115, 1587–1589.

    Article  Google Scholar 

  • Mascheretti S., Bureau A., Trezzi V., Giorda R. and Marino C. 2015 An assessment of gene-by-gene interactions as a tool to unfold missing heritability in dyslexia. Hum. Genet. 134, 749–760.

    Article  CAS  Google Scholar 

  • Newbury D. F., Paracchini S., Scerri T. S., Winchester L., Addis L., Richardson A. J. et al. 2011 Investigation of dyslexia and SLI risk variants in reading- and language-impaired subjects. Behav. Genet. 41, 90–104.

    Article  CAS  Google Scholar 

  • Paracchini S., Thomas A., Castro S., Lai C., Paramasivam M., Wang Y. et al. 2006 The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. Hum. Mol. Genet. 15, 1659–1666.

    Article  CAS  Google Scholar 

  • Shao S., Kong R., Zou L., Zhong R., Lou J., Zhou J. et al. 2016a The roles of genes in the neuronal migration and neurite outgrowth network in developmental dyslexia: single- and multiple-risk genetic variants. Mol. Neurobiol. 53, 3967–3975.

    Article  CAS  Google Scholar 

  • Shao S., Niu Y., Zhang X., Kong R., Wang J., Liu L. et al. 2016b Opposite associations between individual KIAA0319 polymorphisms and developmental dyslexia risk across populations: a stratified meta-analysis by the study population. Sci. Rep. 6, 30454.

    Article  CAS  Google Scholar 

  • Su M., Wang J., Maurer U., Zhang Y., Li J., McBride-Chang C. et al. 2015 Gene-environment interaction on neural mechanisms of orthographic processing in Chinese children. J. Neurolinguistics 33, 172–186.

    Article  Google Scholar 

  • Venkatesh S. K., Siddaiah A., Padakannya P. and Ramachandra N. B. 2011 An examination of candidate gene SNPs for dyslexia in an Indian sample. Behav. Genet. 41, 105–109.

    Article  Google Scholar 

  • Venkatesh S. K., Siddaiah A., Padakannaya P. and Ramachandra N. B. 2013 Analysis of genetic variants of dyslexia candidate genes KIAA0319 and DCDC2 in Indian population. J. Hum. Genet. 58, 531–538.

    Article  CAS  Google Scholar 

  • Zhao H., Chen Y., Zhang B. P. and Zuo P. X. 2016 KIAA0319 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children. J. Hum. Genet. 61, 745–752.

    Article  CAS  Google Scholar 

  • Zou L., Chen W., Shao S., Sun Z., Zhong R., Shi J. et al. 2012 Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: an integrated meta-analysis. Am. J. Med. Genet. B Neuropsychiatr. Genet. 159, 970–976.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This research was supported by the National Natural Science Foundation of China, project no. 81760597.

Author information

Authors and Affiliations

  1. Medical School, University of Shihezi, Xinjiang, 832000, People’s Republic of China

    Ke-Gao Deng, Hua Zhao & Peng-Xiang Zuo

  2. Medical School, Quzhou College of Technology, Zhejiang, 324000, People’s Republic of China

    Hua Zhao

Authors
  1. Ke-Gao Deng
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hua Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peng-Xiang Zuo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Peng-Xiang Zuo.

Additional information

Corresponding Editor: H. A. Ranganath

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Deng, KG., Zhao, H. & Zuo, PX. Association between KIAA0319 SNPs and risk of dyslexia: a meta-analysis. J Genet 98, 62 (2019). https://doi.org/10.1007/s12041-019-1103-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12041-019-1103-4

Keywords

Search

Navigation