Abstract
Pyrimidine-5-carbonitrile and pyrimidine-5-carboxamide were synthesized from the various substituted benzaldehyde, malononitrile and cyanoacetamide, urea/thiourea in the presence of ammonium chloride followed by characterization using IR, \(^{1}\hbox {H NMR}\) spectroscopic technique.
Graphic Abstract
Pyrimidine-5-carbonitrile and pyrimidine-5-carboxamide were synthesized from the various substituted benzaldehyde, malononitrile and cyanoacetamide, urea/thiourea in the presence of ammonium chloride.
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Acknowledgements
The authors are thankful to Maratha Vidya Prasarak Samaj, Nashik for providing infrastructure for research and spectral data. The authors also express their sincere thanks to the Principal, K.R.T. Arts B. H. Commerce and A.M. Science (KTHM) College, Gangapur Road, Nashik and the Principal, K. G. D. M. Arts, Commerce and Science College, Niphad.
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J. S. Aher: Affiliated to Savitribai Phule Pune University (Formerly University of Pune), Maharashtra, India.
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Aher, J.S., kardel, A.V., Gaware, M.R. et al. One pot synthesis of pyrimidine-5-carbonitrile and pyrimidine-5-carboxamide using ammonium chloride under solvent free condition. J Chem Sci 131, 54 (2019). https://doi.org/10.1007/s12039-019-1633-6
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DOI: https://doi.org/10.1007/s12039-019-1633-6