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An efficient and convenient synthesis of N-substituted amides under heterogeneous condition using Al(HSO4)3 via Ritter reaction

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Abstract

An efficient and inexpensive synthesis of N-substituted amides from the reaction of aliphatic and aromatic nitriles with various benzylic alcohols (secondary and tertiary) and tert-butyl alcohol by refluxing nitromethane via the Ritter reaction catalyzed by aluminum hydrogen sulfate [Al(HSO4)3] is described. The catalyst which is an air-stable, cost-effective solid acid could be readily recycled by filtration and reused four times without any significant loss of its activity.

An efficient and inexpensive synthesis of N-substituted amides by refluxing nitromethane via the Ritter reaction catalyzed by aluminum hydrogen sulfate [Al(HSO4)3] is described. The catalyst which is an air-stable, cost-effective solid acid could be readily recycled by filtration and reused four times without any significant loss of its activity.

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Acknowledgements

The authors gratefully acknowledge the partial support of this study by Ferdowsi University of Mashhad Research Council (Grant no. p/ 3/33741).

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, 9177948974, Iran

    ELNAZ KARIMIAN, BATOOL AKHLAGHINIA & SARA S E GHODSINIA

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  1. ELNAZ KARIMIAN
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  2. BATOOL AKHLAGHINIA
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  3. SARA S E GHODSINIA
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Correspondence to BATOOL AKHLAGHINIA.

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KARIMIAN, E., AKHLAGHINIA, B. & E GHODSINIA, S.S. An efficient and convenient synthesis of N-substituted amides under heterogeneous condition using Al(HSO4)3 via Ritter reaction. J Chem Sci 128, 429–439 (2016). https://doi.org/10.1007/s12039-016-1036-x

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  • DOI: https://doi.org/10.1007/s12039-016-1036-x

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