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Dithiocarbamate promoted practical synthesis of N-Aryl-2-aminobenzazoles: Synthesis of novel Aurora-A kinase inhibitor

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Abstract

Various N-aryl-2-aminobenzoxazoles and N-aryl-2-aminobenzothiazoles were synthesized from o-aminophenol and o-aminothiophenol, respectively, mediated by dithiocarbamate in one step. The salient features of this method include mild reaction condition, high yield and large scale synthesis. Application of this methodology has been demonstrated by synthesizing potent Aurora kinase-A inhibitors.

Various N-aryl-2-aminobenzoxazoles and N-aryl-2-aminobenzothiazoles were synthesized from o-aminophenol and o-aminothiophenol, respectively, mediated by dithiocarbamate in one step. Application of this methodology has been demonstrated by synthesizing potent Aurora kinase-A inhibitors.

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Acknowledgments

The authors are very thankful to analytical department of Dr. Reddy’s Laboratories Ltd. for the spectral and analytical data.

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Authors and Affiliations

  1. Department of Chemistry, HTP Campus, GITAM University, Rudraram, Hyderabad, Telangana, 502 329, India

    NARESH KUMAR KATARI, M VENKATANARAYANA & KUMMARI SRINIVAS

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  1. NARESH KUMAR KATARI
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  2. M VENKATANARAYANA
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  3. KUMMARI SRINIVAS
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Correspondence to NARESH KUMAR KATARI.

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Supplementary Information

NMR, IR and mass spectra of the synthesized compounds are reported in Supplementary Information available at www.ias.ac.in/chemsci.

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KATARI, N.K., VENKATANARAYANA, M. & SRINIVAS, K. Dithiocarbamate promoted practical synthesis of N-Aryl-2-aminobenzazoles: Synthesis of novel Aurora-A kinase inhibitor. J Chem Sci 127, 447–453 (2015). https://doi.org/10.1007/s12039-015-0803-4

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  • DOI: https://doi.org/10.1007/s12039-015-0803-4

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