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Electrochemical studies of ropinirole, an anti-Parkinson’s disease drug

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Abstract

The electrochemical behaviour of ropinirole has been examined for the first time. The voltammetric response attributed to the oxidation of indol-2-one ring was used for electroanalytical measurements of drug molecule.

The oxidation behaviour of a potent anti-Parkinson’s disease drug ropinirole hydrochloride was investigated over a wide pH range in aqueous solution at glassy carbon electrode using cyclic and square-wave voltammetry. The oxidation of drug is a pH dependent irreversible process and occurs in two steps. The mechanism of the oxidation process has been discussed. Using the sharp oxidation response in 0.1 M sulphuric acid at a potential of +1.27 V attributed to the oxidation of indol-2-one ring in drug molecule, rapid electroanalytical methods for the determination of ropinirole by pulse voltammetric techniques were developed and validated. The proposed voltammetric methods were applied to direct quantification of ropinirole in film-coated tablets, with results in close agreement (at 95% confidence level) with those obtained using a comparative HPLC method.

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Acknowledgements

This work was supported through a grant (Investigation of new methods in analysis of drugs and bioactive substances) from the Ministry of Science, Education and Sports of the Republic of Croatia.

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Authors and Affiliations

  1. Faculty of Pharmacy and Biochemistry, University of Zagreb, A Kovacica 1, 10000, Zagreb, Croatia

    BILJANA NIGOVIĆ, SANDRA JURIĆ, ANA MORNAR & INES MALENICA

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  1. BILJANA NIGOVIĆ
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  2. SANDRA JURIĆ
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Correspondence to BILJANA NIGOVIĆ.

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NIGOVIĆ, B., JURIĆ, S., MORNAR, A. et al. Electrochemical studies of ropinirole, an anti-Parkinson’s disease drug. J Chem Sci 125, 1197–1205 (2013). https://doi.org/10.1007/s12039-013-0444-4

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  • DOI: https://doi.org/10.1007/s12039-013-0444-4

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