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Synthesis and antiulcer activity of 2-[5-substituted-1-H-benzo(d) imidazol-2-yl sulfinyl]methyl-3-substituted quinazoline-4-(3H) ones

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Abstract

2-[5-substituted-1-H-benzo(d)imidazol-2-yl sulfinyl]methyl-3-substituted quinazoline-4-(3H)-one derivatives were synthesized and tested for antiulcer activity against pylorus ligation-induced, aspirin induced and ethanol induced ulcer in rat model. All the synthesized compounds were characterized by using IR, MS and 1H NMR spectral and elemental analysis. The compounds were scramed for their antiulcer activity: compounds 5k and 5n showed higher activity than omeprazole used as standard.

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Authors and Affiliations

  1. Smt. S.S. Patil College of Pharmacy, Chopda, 425 107, India

    Avinash Patil

  2. Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, 835 215, India

    Swastika Ganguly

  3. R.C. Patel College of Pharmacy, Shirpur, 425 405, India

    Sanjay Surana

Authors
  1. Avinash Patil
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  2. Swastika Ganguly
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  3. Sanjay Surana
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Correspondence to Avinash Patil.

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Patil, A., Ganguly, S. & Surana, S. Synthesis and antiulcer activity of 2-[5-substituted-1-H-benzo(d) imidazol-2-yl sulfinyl]methyl-3-substituted quinazoline-4-(3H) ones. J Chem Sci 122, 443–450 (2010). https://doi.org/10.1007/s12039-010-0052-5

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  • DOI: https://doi.org/10.1007/s12039-010-0052-5

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