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The Regulatory Mechanism of Rab21 in Human Diseases

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Abstract

Rab proteins are important components of small GTPases and play crucial roles in regulating intracellular transportation and cargo delivery. Maintaining the proper functions of Rab proteins is essential for normal cellular activities such as cell signaling, division, and survival. Due to their vital and irreplaceable role in regulating intracellular vesicle transportation, accumulated researches have shown that the abnormalities of Rab proteins and their effectors are closely related to human diseases. Here, this review focused on Rab21, a member of the Rab family, and introduced the structures and functions of Rab21, as well as the regulatory mechanisms of Rab21 in human diseases, including neurodegenerative diseases, cancer, and inflammation. In summary, we described in detail the role of Rab21 in human diseases and provide insights into the potential of Rab21 as a therapeutic target for diseases.

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Acknowledgements

We thank the Biological and Medical Engineering Core Facilities of Beijing Institute of Technology for supplying our experimental equipment.

Funding

This work was supported by the Ministry of Science and Technology major projects (STI2030-Major Projects 2022ZD0206800), the National Natural Science Foundation of China (Grant No. 92049102), Beijing Nova Program (Grant No. 20220484083), and Beijing Municipal Natural Science Foundation (Grant No. 7222113).

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    Xinjian Li, Junjun Ni, Hong Qing & Zhenzhen Quan

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XJ.L and ZZ. Q conceived and designed the studies and wrote the manuscript. JJ. N provided some valuable advice for this article. H. Q edited and advised the manuscript. All authors contributed to the data analysis and presentation in the paper.

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Li, X., Ni, J., Qing, H. et al. The Regulatory Mechanism of Rab21 in Human Diseases. Mol Neurobiol 60, 5944–5953 (2023). https://doi.org/10.1007/s12035-023-03454-0

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