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Cancer and Alzheimer’s Inverse Correlation: an Immunogenetic Analysis

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Abstract

Numerous studies have demonstrated an inverse link between cancer and Alzheimer’s disease (AD), with data suggesting that people with Alzheimer’s have a decreased risk of cancer and vice versa. Although other studies have investigated mechanisms to explain this relationship, the connection between these two diseases remains largely unexplained. Processes seen in cancer, such as decreased apoptosis and increased cell proliferation, seem to be reversed in AD. Given the need for effective therapeutic strategies for AD, comparisons with cancer could yield valuable insights into the disease process and perhaps result in new treatments. Here, through a review of existing literature, we compared the expressions of genes involved in cell proliferation and apoptosis to establish a genetic basis for the reciprocal association between AD and cancer. We discuss an array of genes involved in the aforementioned processes, their relevance to both diseases, and how changes in those genes produce varying effects in either disease.

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This is a review paper. No original data are presented. All data presented are cited with corresponding references and citations.

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Acknowledgements

The authors acknowledge the financial support of the Krembil Foundation.

Funding

This work was supported by an operating grant from the Krembil Foundation.

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  1. Krembil Discovery Tower, Krembil Brain Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada

    Aditya Bhardwaj, S. Imindu Liyanage & Donald F. Weaver

  2. Departments of Medicine and Chemistry, University of Toronto, Toronto, Canada

    Donald F. Weaver

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All authors contributed to the development and writing of this review. The first draft of the manuscript was written by Aditya Bhardwaj and Imindu Liyanage. D. Weaver contributed to all subsequent drafts. All authors commented on all successive versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Donald F. Weaver.

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Bhardwaj, A., Liyanage, S.I. & Weaver, D.F. Cancer and Alzheimer’s Inverse Correlation: an Immunogenetic Analysis. Mol Neurobiol 60, 3086–3099 (2023). https://doi.org/10.1007/s12035-023-03260-8

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