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An Updated Review of Mitochondrial Transplantation as a Potential Therapeutic Strategy Against Cerebral Ischemia and Cerebral Ischemia/Reperfusion Injury

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Abstract

Regardless of the progress made in the pathogenesis of ischemic stroke, it remains a leading cause of adult disability and death. To date, the most effective treatment for ischemic stroke is the timely recanalization of the occluded artery. However, the short time window and reperfusion injury have greatly limited its application and efficacy. Mitochondrial dysfunction and ATP depletion have become regarded as being hallmarks of neuropathophysiology following ischemic stroke. Mitochondrial transplantation is a novel potential therapeutic intervention for ischemic stroke that has sparked widespread concern during the past few years. This review summarizes and discusses the effects of mitochondrial transplantation in in vitro and in vivo ischemic stroke models. In addition, pharmacological interventions promoting mitochondrial transplantation are reviewed and discussed. We also discuss the potential challenges to the clinical application of mitochondrial transplantation in the treatment of ischemic stroke.

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Acknowledgements

All figures are created with BioRender.com.

Funding

This work was supported by the Senior Research Scholar Grant from the National Research Council of Thailand (SCC); Thailand Science Research and Innovation-Chaing Mai University (Fundamental Fund 2565 to SCC); the NSTDA Research Chair grant from the National Science and Technology Development Agency Thailand (NC); and the Chiang Mai University Center of Excellence Award (NC).

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Authors and Affiliations

  1. Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand

    Huatuo Huang, Thura Tun Oo, Nattayaporn Apaijai, Nipon Chattipakorn & Siriporn C Chattipakorn

  2. Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand

    Huatuo Huang, Nattayaporn Apaijai & Nipon Chattipakorn

  3. Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, 50200, Thailand

    Huatuo Huang, Thura Tun Oo, Nattayaporn Apaijai, Nipon Chattipakorn & Siriporn C Chattipakorn

  4. Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand

    Siriporn C Chattipakorn

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  1. Huatuo Huang
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NC and SCC: conception and funding acquisition; HTH: writing-original draft; TOO, NA, NC, and SCC: writing-reviewing and editing.

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Correspondence to Siriporn C Chattipakorn.

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Huang, H., Oo, T.T., Apaijai, N. et al. An Updated Review of Mitochondrial Transplantation as a Potential Therapeutic Strategy Against Cerebral Ischemia and Cerebral Ischemia/Reperfusion Injury. Mol Neurobiol 60, 1865–1883 (2023). https://doi.org/10.1007/s12035-022-03200-y

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