Abstract
Numerous studies indicated that long non-coding RNAs (lncRNAs) play critical roles in glioma initiation and progression. SNHG25 is a newly identified lncRNA. And the functional role and molecular mechanism of SNHG25 in glioma cells have not been investigated. In this study, we found that SNHG25 was upregulated in glioma cells and tissues. CCK-8, EDU, and colony formation assays demonstrated that SNHG25 knockdown markedly inhibited glioma cell proliferation. In vivo studies showed that SNHG25 knockdown significantly inhibited tumor growth. Further studies indicated that SNHG25 positively regulated MAP2K2 through sponging miR-579-5p. High expression of SNHG25 activated MAPK signaling through MAP2K2. These data suggest that SNHG25 is a potential target and biomarker for glioma.
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The datasets used or analyzed during the study are available from the corresponding author on reasonable request.
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Jian Xu designed this study; Zeyu Wu, Peng Lun, and Tao Ji performed the experiments; Jiaojiao Niu, Xiuyan Sun, and Xia Liu analyzed the data; Jian Xu wrote the manuscript. All the authors have revised this manuscript and approved the submission.
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Wu, Z., Lun, P., Ji, T. et al. LncRNA SNHG25 Promotes Glioma Progression Through Activating MAPK Signaling. Mol Neurobiol 59, 6993–7005 (2022). https://doi.org/10.1007/s12035-022-03015-x
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DOI: https://doi.org/10.1007/s12035-022-03015-x