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Charge and rigidity effects on the encapsulation of quercetin by multilamellar vesicles

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Abstract

Although quercetin has a wide range of applications due to its biological properties, its activity may be affected due to its low solubility and its potential for degradation in a physiological environment. The nanoparticulate and microparticulate systems appear as a powerful strategy to enhance its biological activity as well as to contribute to the viability of this compound for pharmacological purposes. Here, we present an innovative and applied research to study the effect of different lipid compositions on the encapsulation of quercetin by using multilamellar vesicles (MLVs). For this purpose, the effects of charge and rigidity in the formulation’s average size, size distribution, charge properties, encapsulation and release efficiencies of this polyphenol were explored. Our results demonstrated that the rigidity imposed by cholesterol increased both the homogeneity of the size distribution and the encapsulation efficiency enabling a significant rate of quercetin release at the system with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/cholesterol (80:20). The charge modulated both the average size and size distribution as well as resulted in high encapsulation and release efficiencies in the formulation composed by (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (80:20). To the best of our knowledge, this is the first study concerning charge and rigidity effects on the encapsulation of quercetin in MLVs. Furthermore, the findings presented in this work is a starting point on the use of lipid composition as a modulating agent of important parameters in the development of nano and micro systems for controlled release.

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Acknowledgements

NBL slade acknowledges the financial support from Research Supporting Foundation of Minas Gerais State (FAPEMIG-Brazil; Grant APQ-00554-21). J A Moreto would like to acknowledge the financial support received from the National Council of Technological and Scientific Development (CNPq-Brazil; Grant 303659/2019-0) and Research Supporting Foundation of Minas Gerais State (FAPEMIG-Brazil; Grant APQ-02276-18). We are thankful to Prof. Dr M P dos Santos Cabrera for donating the quercetin sample, Prof. Dr J Ruggiero Neto for the use of the ZetaSizer Nano ZS90 (Malvern Instruments Ltd, Worcestershire, UK), Prof. Dr P I S Maia and the Biochemistry Department of UFTM for the structures and equipment made available. Mendes also thanks the Coordination for the Improvement of Higher Education Personnel (CAPES) for the scholarship and Graduate Program in Materials Science and Technology (PPGCTM-UFTM).

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  1. These authors have contributed equally to this study.

Authors and Affiliations

  1. Department of Physics, Federal University of Triângulo Mineiro, Uberaba, 38064-300, Brazil

    Luciana Custódio, Leandro Antunes Mendes, Jéferson Aparecido Moreto & Natália Bueno Leite Slade

  2. Department of Physics, São Paulo State University, São José do Rio Preto, SP, 15054-000, Brazil

    Dayane S Alvares

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  1. Luciana Custódio
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  2. Leandro Antunes Mendes
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Correspondence to Natália Bueno Leite Slade.

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Custódio, L., Mendes, L.A., Alvares, D.S. et al. Charge and rigidity effects on the encapsulation of quercetin by multilamellar vesicles. Bull Mater Sci 45, 159 (2022). https://doi.org/10.1007/s12034-022-02734-0

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