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Isoimperatorin-mediated green-synthesized silver nanoparticles: antibacterial, antioxidant, cytotoxicity, hemolytic and coagulation effects

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Abstract

The isolated and pure biological compounds have been widely used in natural-based nanoparticles, entailing applications in medicine, cosmetics and nutrition. In this study, the toxic effects (in vitro) and biomedical applications of isoimperatorin-mediated green synthesized silver nanoparticles (Iso-AgNPs) were investigated. The in vitro antioxidant, antibacterial and cytotoxic potential were determined by using standard protocols. Besides, blood compatibility was determined by hemolysis and coagulation tests. Based on the obtained results, Iso-AgNPs showed enhanced antioxidant capacity in comparison with the crude isoimperatorin and were found effective against the pathogenic bacterial strains. Cell viability study reveals the safety of Iso-AgNPs on H1299 and MCF-7 cell lines, and no significant cytotoxicity was observed. The non-hemolytic effect of Iso-AgNPs on erythrocyte cells (RBCs) and the absence of coagulation indicate high blood compatibility of these nanoparticles, which make them unique in comparison to the other silver nanoparticles. Altogether, our finding confirms the biological advantages of Iso-AgNPs as a cyto- and blood-compatible antibacterial and antioxidant nano-metal.

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References

  1. Burdusel A C, Gherasim O, Grumezescu A M, Mogoantă L, Ficai A and Andronescu E 2018 Nanomaterials 8 681

    Article  Google Scholar 

  2. Kotcherlakota R, Das S and Patra C R 2019 in Green synthesis, characterization and applications of nanoparticles (Netherlands; UK; US: Elsevier) p 389

  3. Lee S H and Jun B H 2019 Int. J. Mol. Sci. 20 865

    Article  CAS  Google Scholar 

  4. Paladini F and Pollini M 2019 Materials (Basel) 12 2540

    Article  CAS  Google Scholar 

  5. Rigo C, Ferroni L, Tocco I, Roman M, Munivrana I, Gardin C et al 2013 Int. J. Mol. Sci. 14 4817

    Article  CAS  Google Scholar 

  6. Sreekanth T V M, Ravikumar S and Eom I Y 2014 J. Photochem. Photobiol. B Biol. 141 100

    Article  CAS  Google Scholar 

  7. Tien D C, Liao C Y, Huang J C, Tseng K H, Lung J K, Tsung T T et al 2008 Rev. Adv. Mater. Sci. 18 750

    Google Scholar 

  8. Kumar B, Smita K, Seqqat R, Benalcazar K, Grijalva M and Cumbal L 2016 J. Photochem. Photobiol. B Biol. 159 8

    Article  CAS  Google Scholar 

  9. Sathishkumar P, Gu F L, Zhan Q, Palvannan T and Yusoff A R M 2018 Mater. Lett. 210 26

    Article  CAS  Google Scholar 

  10. Švecová M, Ulbrich P, Dendisová M and Matějka P 2018 Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 195 236

    Article  Google Scholar 

  11. Griffin S, Masood M I, Nasim M J, Sarfraz M, Ebokaiwe A P, Schäfer K H et al 2018 Antioxidants 7 3

    Article  Google Scholar 

  12. Mavaei M, Chahardoli A, Shokoohinia Y, Khoshroo A and Fattahi A 2020 Sci. Rep. 10 1

    Article  Google Scholar 

  13. Chahardoli A, Karimi N and Fattahi A 2018 Adv. Powder Technol. 29 202

    Article  CAS  Google Scholar 

  14. Chahardoli A, Karimi N, Fattahi A and Salimikia I 2019 J. Biomed. Mater. Res. Part A 107 621

    Article  CAS  Google Scholar 

  15. Chahardoli A, Karimi N, Sadeghi F and Fattahi A 2018 Artif. Cells Nanomed. Biotechnol. 46 579

    CAS  Google Scholar 

  16. Devi L B, Das S K and Mandal A B 2014 J. Phys. Chem. C 118 29739

    Article  CAS  Google Scholar 

  17. Yang J Y, Bae J, Jung A, Park S, Chung S, Seok J et al 2017 PLoS One 12 0181634

    Google Scholar 

  18. Widelski J, Popova M, Graikou K, Glowniak K and Chinou I 2009 Molecules 14 2729

    Article  CAS  Google Scholar 

  19. Shan Y, Xu C, Wang M, Zhu Z, Wu F G, Shi Z et al 2019 Talanta 192 154

    Article  CAS  Google Scholar 

  20. Azam M W and Khan A U 2019 Drug Discov. Today 24 350

    Article  CAS  Google Scholar 

  21. Yuan Y, Qu K, Tan D, Li X, Wang L, Cong C et al 2019 Microb. Pathog. 128 329

    Article  CAS  Google Scholar 

  22. Ersoz G, Uguz M, Aslan G, Horasan E S and Kaya A 2014 J. Hosp. Infect. 87 122

    Article  CAS  Google Scholar 

  23. Zhang X F, Shen W and Gurunathan S 2016 Int. J. Mol. Sci. 17 1603

    Article  Google Scholar 

  24. Chahardoli A, Karimi N and Fattahi A 2017 Iran. J. Pharm. Res. 16 1167

    CAS  Google Scholar 

  25. Hussain S M, Hess K L, Gearhart J M, Geiss K T and Schlager J J 2005 Toxicol. Vitr. 19 975

    Article  CAS  Google Scholar 

  26. Greulich C, Kittler S, Epple M, Muhr G and Köller M 2009 Langenbeck’s Arch. Surg. 394 495

    Article  CAS  Google Scholar 

  27. Wang J, Rahman M F, Duhart H M, Newport G D, Patterson T A, Murdock R C et al 2009 Neurotoxicology 30 926

    Article  Google Scholar 

  28. Chun J Y, Kang H K, Jeong L, Kang Y O, Oh J E, Yeo I S et al 2010 Colloid Surf. B Biointerfaces 78 334

    Article  CAS  Google Scholar 

  29. Kim H R, Kim M J, Lee S Y, Oh S M and Chung K H 2011 Mutat. Res. Toxicol Environ. Mutagen. 726 129

    Article  CAS  Google Scholar 

  30. Pratsinis A, Hervella P, Leroux J, Pratsinis S E and Sotiriou G A 2013 Small 9 2576

    Article  CAS  Google Scholar 

  31. Szmyd R, Goralczyk A G, Skalniak L, Cierniak A, Lipert B, Filon F L et al 2013 Biol. Chem. 394 113

    Article  CAS  Google Scholar 

  32. Gurunathan S, Jeong J K, Han J W, Zhang X F, Park J H and Kim J H 2015 Nanoscale Res. Lett. 10 1

    Article  CAS  Google Scholar 

  33. Rajan A, Vilas V and Philip D 2015 J. Mol. Liq. 212 331

    Article  CAS  Google Scholar 

  34. Kharat S N and Mendhulkar V D 2016 Mater. Sci. Eng. C 62 719

    Article  CAS  Google Scholar 

  35. Chang S T, Wu J H, Wang S Y, Kang P L, Yang N S and Shyur L F 2001 J. Agric. Food Chem. 49 3420

    Article  CAS  Google Scholar 

  36. Mittal A K, Bhaumik J, Kumar S and Banerjee U C 2014 J. Colloid Interface Sci. 415 39

    Article  CAS  Google Scholar 

  37. Kumar B, Smita K, Cumbal L and Debut A 2016 Bionanoscience 6 15

    Article  Google Scholar 

  38. Abdel-Aziz M S, Shaheen M S, El-Nekeety A A and Abdel-Wahhab M A 2014 J. Saudi Chem. Soc. 18 356

    Article  Google Scholar 

  39. Parthiban E, Manivannan N, Ramanibai R and Mathivanan N 2019 Reports 21 00297

    Google Scholar 

  40. Urbagarova B M, Shults E E, Taraskin V V, Radnaeva L D, Petrova T N, Rybalova T V et al 2020 J. Ethnopharmacol. 2020 112517

  41. Huang H, Lai W, Cui M, Liang L, Lin Y, Fang Q et al 2016 Sci. Rep. 6 25518

    Article  CAS  Google Scholar 

  42. Ashokraja C, Sakar M and Balakumar S 2017 Mater. Res. Express. 4 105406

  43. Fröhlich E 2016 Curr. Med. Chem. 23 408

    Article  Google Scholar 

Download references

Acknowledgements

We gratefully acknowledge the Research Council of Kermanshah University of Medical Sciences and the National Institute for Medicinal Research Development (NIMAD) for financial support.

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Authors and Affiliations

  1. Department of Biology, Faculty of Sciences, Razi University, Kermanshah, 6714414971, Iran

    Azam Chahardoli

  2. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran

    Farshad Qalekhani, Yalda Shokoohinia & Ali Fattahi

  3. Ric Scalzo Institute for Botanical Research, Southwest College of Naturopathic Medicine, Tempe, 85282, USA

    Yalda Shokoohinia

  4. Medical Biology Research Center, Health Technologies Institute, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran

    Ali Fattahi

Authors
  1. Azam Chahardoli
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  2. Farshad Qalekhani
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  3. Yalda Shokoohinia
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  4. Ali Fattahi
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Correspondence to Azam Chahardoli.

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Chahardoli, A., Qalekhani, F., Shokoohinia, Y. et al. Isoimperatorin-mediated green-synthesized silver nanoparticles: antibacterial, antioxidant, cytotoxicity, hemolytic and coagulation effects. Bull Mater Sci 45, 88 (2022). https://doi.org/10.1007/s12034-022-02665-w

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  • DOI: https://doi.org/10.1007/s12034-022-02665-w

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