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Chitosan nanoparticles containing Physalis alkekengi-L extract: preparation, optimization and their antioxidant activity

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Abstract

Physalis alkekengi-L is a medicinal herb with a high antioxidant capacity. It is used to treat various diseases. In this study, encapsulation of the hydro-alcoholic extract of P. alkekengi-L into chitosan nanoparticles (CNPs) was optimized by using response surface methodology, and its antioxidant capacity and anticancer activity were investigated. The results of the antioxidant capacity evaluation showed that the antioxidant activity of the chitosan nanoparticles containing extract did not significantly decrease by increasing the time of storage (over a 12 day period) as compared to that of un-encapsulated extracts. In conclusion, CNPs can be used to encapsulate and improve the stability of P. alkekengi-L extract and its antioxidantproperties.

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Acknowledgements

This work was financially supported by the Yasuj University of Medical Sciences.

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Authors and Affiliations

  1. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, 7591994799, Iran

    Reza Mahmoudi, Maryam Tajali Ardakani, Sajad Afrouz & Hassan Bardania

  2. Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 14115-111, Iran

    Behnam Hajipour Verdom

  3. Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, 48471–91971, Iran

    Abouzar Bagheri

  4. Interdisciplinary Nanoscience Centre (iNANO) and Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 14, DK-8000, Aarhus C, Denmark

    Hossein Mohammad-Beigi

  5. Bioprocess Engineering Department, Institute of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, 1497716316, Iran

    Farhang Aliakbari

  6. Department and Center for Biotechnology Research, School of Medicine, Semnan, 35198-99951, Iran

    Farhang Aliakbari

  7. Medicinal Plant Research Center, Yasuj University of Medical Sciences, Yasuj, 7591994799, Iran

    Zeinab Salehpour

  8. Department of Advanced Medical Sciences and Technologies, School of Medicine, Jahrom University of Medical Sciences, Jahrom, 7414846199, Iran

    Mohsen Alipour

Authors
  1. Reza Mahmoudi
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  2. Maryam Tajali Ardakani
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  3. Behnam Hajipour Verdom
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  4. Abouzar Bagheri
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  5. Hossein Mohammad-Beigi
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  6. Farhang Aliakbari
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  7. Zeinab Salehpour
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  8. Mohsen Alipour
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  9. Sajad Afrouz
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  10. Hassan Bardania
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Corresponding author

Correspondence to Hassan Bardania.

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Mahmoudi, R., Tajali Ardakani, M., Hajipour Verdom, B. et al. Chitosan nanoparticles containing Physalis alkekengi-L extract: preparation, optimization and their antioxidant activity. Bull Mater Sci 42, 131 (2019). https://doi.org/10.1007/s12034-019-1815-3

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  • DOI: https://doi.org/10.1007/s12034-019-1815-3

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