Chitosan nanoparticles containing Physalis alkekengi-L extract: preparation, optimization and their antioxidant activity

  • Reza Mahmoudi
  • Maryam Tajali Ardakani
  • Behnam Hajipour Verdom
  • Abouzar Bagheri
  • Hossein Mohammad-Beigi
  • Farhang Aliakbari
  • Zeinab Salehpour
  • Mohsen Alipour
  • Sajad Afrouz
  • Hassan BardaniaEmail author


Physalis alkekengi-L is a medicinal herb with a high antioxidant capacity. It is used to treat various diseases. In this study, encapsulation of the hydro-alcoholic extract of P. alkekengi-L into chitosan nanoparticles (CNPs) was optimized by using response surface methodology, and its antioxidant capacity and anticancer activity were investigated. The results of the antioxidant capacity evaluation showed that the antioxidant activity of the chitosan nanoparticles containing extract did not significantly decrease by increasing the time of storage (over a 12 day period) as compared to that of un-encapsulated extracts. In conclusion, CNPs can be used to encapsulate and improve the stability of P. alkekengi-L extract and its antioxidantproperties.


Physalis alkekengi-L chitosan nanoparticles antioxidant activity stability of extract 



This work was financially supported by the Yasuj University of Medical Sciences.

Supplementary material

12034_2019_1815_MOESM1_ESM.doc (76 kb)
Supplementary material 1 (doc 76 KB)
12034_2019_1815_MOESM2_ESM.jpg (34 kb)
Supplementary material 2 (jpg 33 KB)
12034_2019_1815_MOESM3_ESM.jpg (282 kb)
Supplementary material 3 (jpg 282 KB)


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Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  • Reza Mahmoudi
    • 1
  • Maryam Tajali Ardakani
    • 1
  • Behnam Hajipour Verdom
    • 2
  • Abouzar Bagheri
    • 3
  • Hossein Mohammad-Beigi
    • 4
  • Farhang Aliakbari
    • 5
    • 6
  • Zeinab Salehpour
    • 7
  • Mohsen Alipour
    • 8
  • Sajad Afrouz
    • 1
  • Hassan Bardania
    • 1
    Email author
  1. 1.Cellular and Molecular Research CenterYasuj University of Medical SciencesYasujIran
  2. 2.Department of Biophysics, Faculty of Biological SciencesTarbiat Modares UniversityTehranIran
  3. 3.Department of Clinical Biochemistry and Genetics, Faculty of MedicineMazandaran University of Medical SciencesSariIran
  4. 4.Interdisciplinary Nanoscience Centre (iNANO) and Department of Molecular Biology and GeneticsAarhus UniversityAarhus CDenmark
  5. 5.Bioprocess Engineering Department, Institute of Industrial and Environmental BiotechnologyNational Institute of Genetic Engineering and BiotechnologyTehranIran
  6. 6.Department and Center for Biotechnology Research, School of MedicineSemnanIran
  7. 7.Medicinal Plant Research CenterYasuj University of Medical SciencesYasujIran
  8. 8.Department of Advanced Medical Sciences and Technologies, School of MedicineJahrom University of Medical SciencesJahromIran

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