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Recent Insights into the Roles of PEST‐Containing Nuclear Protein

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Abstract

PEST-containing nuclear protein (PCNP), a short-lived small nuclear protein with 178 amino acids, is a nuclear protein containing two PEST sequences. PCNP is highly expressed in several malignant tumors such as cervical cancer, rectal cancer, and lung cancer. It is also associated with cell cycle regulation and the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) and Wnt signaling pathways during tumor growth. The present article discuss how PCNP regulates the PI3K/AKT/mTOR and Wnt signaling pathways and related proteins, and the ubiquitination of PCNP regulates tumor cell cycle as well as the progress of the application of PCNP in the pathophysiology and treatment of colon cancer, human ovarian cancer, thyroid cancer, lung adenocarcinoma and oral squamous cell carcinoma. The main relevant articles were retrieved from PubMed, with keywords such as PEST-containing nuclear protein (PCNP), cancer (tumor), and signaling pathways as inclusion/exclusion criteria. Relevant references has been included and cited in the manuscript.

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Funding

This work was supported by the Program for Innovative Talents of Science and Technology in Henan Province (No. 23HASTIT043), the Natural Science Foundation of Henan Province for Excellent Young Scholars (No. 212300410026), the Medical Science and Technology Program of Henan Province (No. SBGJ202103096), and the Program for Young Key Teacher of Henan Province (No. 2020GGJS037).

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  1. Shiyun Guo and Ruidong Ding have contributed equally to this work.

Authors and Affiliations

  1. Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, Henan, China

    Shiyun Guo, Ruidong Ding, Qian Zhao, Xu Wang, Shuangyu Lv & Xin-Ying Ji

  2. Kaifeng Key Laboratory for Infectious Diseases and Biosafety, Kaifeng, 475004, Henan, China

    Xin-Ying Ji

  3. Faculty of Basic Medical Subjects, Shu-Qing Medical College of Zhengzhou, Mazhai, Erqi District, Zhengzhou, 450064, Henan, China

    Xin-Ying Ji

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Conceptualization: SL and XJ; writing—original draft: SG, RD, QZ, and XW; writing—review and editing: SL and XJ.

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Guo, S., Ding, R., Zhao, Q. et al. Recent Insights into the Roles of PEST‐Containing Nuclear Protein. Mol Biotechnol (2024). https://doi.org/10.1007/s12033-024-01188-5

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