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Comprehensive Analysis of ABCA Family Members in Lung Adenocarcinoma with Prognostic Values

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Abstract

ATP-binding cassette subfamily A (ABCA) has received wide recognition because it possesses the capacity to translocate its derivatives, xenobiotics, vitamins, and cholesterol across biological membranes. Some ABCA members have causative relevance to inborn diseases, and a number of studies have explored their functions in cancer progression and metastasis. Here, we explored the interrelation between ABCA genes and lung adenocarcinoma (LUAD). We specified the expression and functions of ABCA members in LUAD using the GEPIA, GEO, Human Protein Atlas, UALCAN, TIMER, and Kaplan–Meier Plotter databases. ABCA5, ABCA6, ABCA8, ABCA9, and ABCA10 were found to be significantly less expressed in LUAD and correlated with TP53 mutation in patients with LUAD. Furthermore, ABCA5, ABCA6, and ABCA8 were relevant to overall survival of patients with LUAD. In conclusion, this study showed that ABCA members may be related to the TP53 mutation of LUAD. Moreover, it may serve as a potential marker for the prognosis of LUAD.

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Funding

This work was supported by the Special Funds of Science and Technology Development of the Chinese Central Government to guide Local in 2020 (An innovation platform for improving the prevention and treatment of frequently occurring diseases in Gansu Province).

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Authors and Affiliations

  1. Department of Respiratory and Critical Care Medicine, Second People’s Hospital of Gansu Province, Lanzhou, 730000, Gansu, China

    Yanxia Yang, Xiaoping Liu, Xin Wang, Jie Zhang, Shuhua Li & Xueping Ma

  2. Affiliated Hospital of Northwest University for Nationalities, Lanzhou, 730000, Gansu, China

    Yanxia Yang, Xiaoping Liu, Xin Wang, Jie Zhang, Shuhua Li & Xueping Ma

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  1. Yanxia Yang
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  2. Xiaoping Liu
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  3. Xin Wang
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Correspondence to Xueping Ma.

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Yang, Y., Liu, X., Wang, X. et al. Comprehensive Analysis of ABCA Family Members in Lung Adenocarcinoma with Prognostic Values. Mol Biotechnol 64, 1441–1453 (2022). https://doi.org/10.1007/s12033-022-00506-z

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