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LncRNA-TUG1 Downregulation is Correlated with the Development of Progressive Chronic Kidney Disease Among Patients with Congestive Heart Failure

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Abstract

TUG1 is an lncRNA that plays a critical role in kidney injury. Our preliminary sequencing analysis showed altered TUG1 expression in both congestive heart failure (CHF) patients and CHF patients complicated with chronic kidney disease (CKD). We then studied the role of TUG1 in these two diseases. We enrolled 120 CHF patients without obvious complications, 60 CHF patients complicated with CKD, and 60 healthy volunteers. TUG1 expression in plasma samples from these participants was determined using RT-qPCR. The diagnostic value of TUG1 for CKD development in CHF patients was evaluated by ROC curve analysis. A 2-year follow-up was performed to detect the correlation between TUG1 expression levels and the development of CKD in CHF. TUG1 was lowly expressed in CHF patients and was further downregulated in CHF patients complicated with progressive CKD. ROC curve analysis showed that plasma TUG1 expression levels could be used to distinguish CHF patients complicated with CKD from CHF patients without CKD and healthy controls. During the 2-year follow-up, high CHF expression levels predicted a low incidence of progressive CKD among CHF patients. With the treatment of progressive CHF + CKD, plasma TUG1 was upregulated. LncRNA-TUG1 downregulation may develop the progressive CKD among patients with CHF.

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Author notes

  1. Wei Zhao and Yuan Zhang have contributed equally to the work.

Authors and Affiliations

  1. Department of Emergency, First Affiliated Hospital of Tianjin University of Chinese Medicine, No. 88 Changling Road, Liqizhuang Street, Xiqing District, Tianjin City, 300000, People’s Republic of China

    Wei Zhao & Xuezheng Liu

  2. Department of Pediatrics, First Affiliated Hospital of Tianjin University of Chinese Medicine, Tianjin City, 300000, People’s Republic of China

    Yuan Zhang

  3. Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin City, 300000, People’s Republic of China

    Mingzhu Zhang & Xiaohan Li

  4. Department of Nephrology, First Affiliated Hospital of Tianjin University of Chinese Medicine, Tianjin City, 300000, People’s Republic of China

    Yong Zhi

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  1. Wei Zhao
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  2. Yuan Zhang
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  3. Mingzhu Zhang
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  4. Yong Zhi
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  5. Xiaohan Li
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  6. Xuezheng Liu
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Correspondence to Xuezheng Liu.

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Zhao, W., Zhang, Y., Zhang, M. et al. LncRNA-TUG1 Downregulation is Correlated with the Development of Progressive Chronic Kidney Disease Among Patients with Congestive Heart Failure. Mol Biotechnol 64, 493–498 (2022). https://doi.org/10.1007/s12033-021-00427-3

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  • DOI: https://doi.org/10.1007/s12033-021-00427-3

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