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Recent Advances in Nano-Bio-Sensing Fabrication Technology for the Detection of Oral Cancer

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Abstract

Nanotechnology-based miniaturized devices have been a breakthrough in the pre-clinical and clinical research areas, e.g. drug delivery, personalized medicine. They have revolutionized the discovery and development of biomarker-based diagnostic devices for detection of various diseases such as tuberculosis, malaria and cancer. Nanomaterials (NMs) hold tremendous diagnostic potential due to their high surface-to-volume ratio and quantum confinement phenomenon, improving the detection limit of clinically relevant biomolecules in bio-fluids. Thus, they are helpful in the translation of bench-on platform to point-of-care (POC) screening device. The nanomaterial-based biosensor fabrication technology has also simplified and improved oral cancer (OC) or oral squamous cell carcinomas (OSCC) diagnosis. The fabrication of nano-bio sensors involves application specific modifications of NMs. The unique properties functionalized NMs have augmented their application on the nano-biosensing platform for the detection of clinically relevant biomolecules in bio-fluids. Therefore, this article summarizes the recent advancements in the process of fabrication of nano-biosensors for detection of OC.

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Acknowledgements

The authors would like to acknowledge the Department of Health Research – Multidisciplinary Research Unit, King George’s Research Unit, Lucknow for providing the required infrastructure to prepare this manuscript. SV would like to acknowledge the Indian Council of Medical Research, New Delhi, India for the Research Associate fellowship.

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No funding was received to assist with the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Health Research – Multidisciplinary Research Unit, King George’s Medical University, Lucknow, 226003, Uttar Pradesh, India

    Jaya Singhal, Saurabh Verma, Sumit Kumar & Divya Mehrotra

  2. Department of Oral and Maxillofacial Surgery, King George’s Medical University, Lucknow, 226003, Uttar Pradesh, India

    Jaya Singhal & Divya Mehrotra

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  1. Jaya Singhal
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  2. Saurabh Verma
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  3. Sumit Kumar
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  4. Divya Mehrotra
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JS and SK conceived the idea, JS and SV prepared the manuscript, JS performed the literature search and data analysis, JS and SV prepared illustration, SK and DM helped in drafting and critical review of the manuscript.

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Correspondence to Sumit Kumar or Divya Mehrotra.

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Singhal, J., Verma, S., Kumar, S. et al. Recent Advances in Nano-Bio-Sensing Fabrication Technology for the Detection of Oral Cancer. Mol Biotechnol 63, 339–362 (2021). https://doi.org/10.1007/s12033-021-00306-x

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