Abstract
Cancer biomarkers play an essential role in early diagnosis, progression, prediction, and potential response of treatment in cancer patients. However, the traditional cancer biomarkers detection techniques lack specificity and selectivity with drawbacks, such as irreproducibility and overdiagnosis. Nanomaterials, with their unique properties, provide efficient, reliable biosensing methods with high sensitivity and selectivity. This chapter represents an overview of the development of nanomaterials-based biosensing techniques and the integration of these nanomaterials in other techniques, such as mass spectrometry (MS), Raman spectroscopy, optical detection, electrical and electrochemical detection, and lab-on-a-chip technology for detection of cancer biomarkers.
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References
Aristotelous T, Hopkins AL, Navratilova I (2015) Surface plasmon resonance analysis of seven-transmembrane receptors. Methods Enzymol 556:499–525. https://doi.org/10.1016/bs.mie.2015.01.016
Arkan E, Saber R, Karimi Z, Shamsipur M (2015) A novel antibody-antigen based impedimetric immunosensor for low level detection of HER2 in serum samples of breast cancer patients via modification of a gold nanoparticles decorated multiwall carbon nanotube-ionic liquid electrode. Anal Chim Acta 874:66–74. https://doi.org/10.1016/j.aca.2015.03.022
Avci-Adali M, Perle N, Ziemer G, Wendel HP (2011) Current concepts and new developments for autologous in vivo endothelialisation of biomaterials for intravascular applications. Eur Cell Mater 21:157–176. https://doi.org/10.22203/eCM.v021a13
Balasubramanian K, Burghard M (2005) Chemically functionalized carbon nanotubes. Small 1:180–192. https://doi.org/10.1002/smll.200400118
Battistella C, Klok HA (2017) Controlling and monitoring intracellular delivery of anticancer polymer nanomedicines. Macromol Biosci 17:1–26. https://doi.org/10.1002/mabi.201700022
Bi S, Zhou H, Zhang S (2009) Multilayers enzyme-coated carbon nanotubes as biolabel for ultrasensitive chemiluminescence immunoassay of cancer biomarker. Biosens Bioelectron 24:2961–2966. https://doi.org/10.1016/j.bios.2009.03.002
Biju V (2014) Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy. Chem Soc Rev 43:744–764. https://doi.org/10.1039/c3cs60273g
Blundell ELCJ, Mayne LJ, Lickorish M et al (2016) Protein detection using tunable pores: resistive pulses and current rectification. Faraday Discuss 193:487–505. https://doi.org/10.1039/c6fd00072j
Chen J, Mishra L, Su X (2015) The landscape of DNA virus associations across human cancers. In: Wu W, Choudhry H (eds) Next generation sequencing in cancer research, volume 2: from basepairs to bedsides. Springer International Publishing, Cham, pp 303–315
Chen Y, Zhang Y, Pan F et al (2016) Breath analysis based on surface-enhanced Raman scattering sensors distinguishes early and advanced gastric cancer patients from healthy persons. ACS Nano 10:8169–8179. https://doi.org/10.1021/acsnano.6b01441
Chinen AB, Guan CM, Ferrer JR et al (2015) Nanoparticle probes for the detection of cancer biomarkers, cells, and tissues by fluorescence. Chem Rev 115:10530–10574. https://doi.org/10.1021/acs.chemrev.5b00321
Cottet V, Pariente A, Nalet B et al (2006) Low compliance with colonoscopic screening in first-degree relatives of patients with large adenomas. Aliment Pharmacol Ther 24:101–109. https://doi.org/10.1111/j.1365-2036.2006.02966.x
Dinish US, Balasundaram G, Chang YT, Olivo M (2014a) Sensitive multiplex detection of serological liver cancer biomarkers using SERS-active photonic crystal fiber probe. J Biophotonics 7:956–965. https://doi.org/10.1002/jbio.201300084
Dinish US, Balasundaram G, Chang YT, Olivo M (2014b) Actively targeted in vivo multiplex detection of intrinsic cancer biomarkers using biocompatible SERS nanotags. Sci Rep 4:1–7. https://doi.org/10.1038/srep04075
Doria G, Conde J, Veigas B et al (2012) Noble metal nanoparticles for biosensing applications. Sensors 12:1657–1687. https://doi.org/10.3390/s120201657
Downes A, Elfick A (2010) Raman spectroscopy and related techniques in biomedicine. Sensors 10(3):1871–1889. https://doi.org/10.3390/s100301871
Duffy MJ (2001) Carcinoembryonic antigen as a marker for colorectal cancer: Is it clinically useful? Clin Chem 47:624–630. https://doi.org/10.1093/clinchem/47.4.624
Etzioni R, Penson DF, Legler JM et al (2002) Overdiagnosis due to prostate-specific antigen screening: Lessons from U.S. prostate cancer incidence trends. J Natl Cancer Inst 94:981–990. https://doi.org/10.1093/jnci/94.13.981
Freeman R, Willner I (2012) Optical molecular sensing with semiconductor quantum dots (QDs). Chem Soc Rev 41:4067–4085. https://doi.org/10.1039/c2cs15357b
Garcia-Cortes M, Encinar JR, Costa-Fernandez JM, Sanz-Medel A (2016) Highly sensitive nanoparticle-based immunoassays with elemental detection: Application to Prostate-Specific Antigen quantification. Biosens Bioelectron 85:128–134. https://doi.org/10.1016/j.bios.2016.04.090
Ghazani AA, Lee JA, Klostranec J et al (2006) High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals. Nano Lett 6:2881–2886. https://doi.org/10.1021/nl062111n
Goossens N, Nakagawa S, Sun X, Hoshida Y (2015) Cancer biomarker discovery and validation. Transl Cancer Res 4:256–269. https://doi.org/10.3978/j.issn.2218-676X.2015.06.04
Gopinath SCB, Citartan M, Lakshmipriya T, Tang T-H, Chen Y (2015) Gold nanoparticles in biosensing analyses. In: Lungu M, Neculae A, Bunoiu M, Biris C (eds) Nanoparticles' promises and risks: characterization, manipulation, and potential hazards to humanity and the environment. Springer International Publishing, Cham, pp 221–234
Grinyte R, Barroso J, Möller M et al (2016) Microbead QD-ELISA: microbead ELISA using biocatalytic formation of quantum dots for ultra high sensitive optical and electrochemical detection. ACS Appl Mater Interfaces 8:29252–29260. https://doi.org/10.1021/acsami.6b08362
Grubisha DS, Lipert RJ, Park HY et al (2003) Femtomolar detection of prostate-specific antigen: an immunoassay based on surface-enhanced Raman scattering and immunogold labels. Anal Chem 75:5936–5943. https://doi.org/10.1021/ac034356f
Gustafsson S, Fornara A, Petersson K et al (2010) Evolution of structural and magnetic properties of magnetite nanoparticles for biomedical applications. Cryst Growth Des 10:2278–2284. https://doi.org/10.1021/cg901602w
Harun NA, Benning MJ, Horrocks BR, Fulton DA (2013) Gold nanoparticle-enhanced luminescence of silicon quantum dots co-encapsulated in polymer nanoparticles. Nanoscale. Accepted M
Hosseini M, Ahmadi E, Borghei YS, Ganjali MR (2017) A new fluorescence turn-on nanobiosensor for the detection of micro-RNA-21 based on a DNA-gold nanocluster. Methods Appl Fluoresc 5(1):015005. https://doi.org/10.1088/2050-6120/aa5e57
Hsu PI, Chen CH, Hsiao M et al (2010) Diagnosis of gastric malignancy using gastric juice α1-antitrypsin. Cancer Epidemiol Biomark Prev 19:405–411. https://doi.org/10.1158/1055-9965.EPI-09-0609
Hu C, Xu K, Cao H et al (2012) Ag@BSA core/shell microspheres as an electrochemical interface for sensitive detection of urinary retinal-binding protein. Anal Chem 84:10324–10331
Huang Y, Li H, Wang L et al (2016) Highly sensitive protein detection based on smart hybrid nanocomposite-controlled switch of DNA polymerase activity. ACS Appl Mater Interfaces 8:28202–28207. https://doi.org/10.1021/acsami.6b09270
Hull LC, Farrell D, Grodzinski P (2014) Highlights of recent developments and trends in cancer nanotechnology research-view from NCI alliance for nanotechnology in cancer. Biotechnol Adv 32:666–678. https://doi.org/10.1016/j.biotechadv.2013.08.003
Imperiale TF, Ransohoff DF, Itzkowitz SH et al (2014) Multitarget stool DNA testing for colorectal-cancer screening. N Engl J Med 370:1287–1297. https://doi.org/10.1056/nejmoa1311194
Jensen GC, Krause CE, Sotzing GA, Rusling JF (2011) Inkjet-printed gold nanoparticle electrochemical arrays on plastic. Application to immunodetection of a cancer biomarker protein. Phys Chem Chem Phys 13:4888–4894. https://doi.org/10.1039/c0cp01755h
Jiang Z, Le NDB, Gupta A, Rotello VM (2015) Cell surface-based sensing with metallic nanoparticles. Chem Soc Rev 44:4264–4274. https://doi.org/10.1039/c4cs00387j
Jie G, Wang L, Zhang S (2011) Magnetic electrochemiluminescent Fe3O4/CdSe-CdS nanoparticle/polyelectrolyte nanocomposite for highly efficient immunosensing of a cancer biomarker. Chem A Eur J 17:641–648. https://doi.org/10.1002/chem.201001128
Jokerst JV, Raamanathan A, Christodoulides N et al (2009) Nano-bio-chips for high performance multiplexed protein detection: determinations of cancer biomarkers in serum and saliva using quantum dot bioconjugate labels. Biosens Bioelectron 24:3622–3629. https://doi.org/10.1016/j.bios.2009.05.026
Jou AFJ, Lu CH, Ou YC et al (2015) Diagnosing the miR-141 prostate cancer biomarker using nucleic acid-functionalized CdSe/ZnS QDs and telomerase. Chem Sci 6:659–665. https://doi.org/10.1039/c4sc02104e
Kagan CR, Fernandez LE, Gogotsi Y et al (2016) Nano day: celebrating the next decade of nanoscience and nanotechnology. ACS Nano 10:9093–9103. https://doi.org/10.1021/acsnano.6b06655
Kavosi B, Salimi A, Hallaj R, Moradi F (2015) Ultrasensitive electrochemical immunosensor for PSA biomarker detection in prostate cancer cells using gold nanoparticles/PAMAM dendrimer loaded with enzyme linked aptamer as integrated triple signal amplification strategy. Biosens Bioelectron 74:915–923. https://doi.org/10.1016/j.bios.2015.07.064
Khazanov E, Yavin E, Pascal A et al (2012) Detecting a secreted gastric cancer biomarker molecule by targeted nanoparticles for real-time diagnostics. Pharm Res 29:983–993. https://doi.org/10.1007/s11095-011-0638-8
Kim DR, Lee CH, Zheng X (2009a) Probing flow velocity with silicon nanowire sensors. Nano Lett 9:1984–1988. https://doi.org/10.1021/nl900238a
Kim JP, Lee BY, Lee J et al (2009b) Enhancement of sensitivity and specificity by surface modification of carbon nanotubes in diagnosis of prostate cancer based on carbon nanotube field effect transistors. Biosens Bioelectron 24:3372–3378. https://doi.org/10.1016/j.bios.2009.04.048
Kwong GA, Von Maltzahn G, Murugappan G et al (2013) Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease. Nat Biotechnol 31:63–70. https://doi.org/10.1038/nbt.2464
Lassere M (2008) The biomarker-surrogacy evaluation schema: a review of the biomarker-surrogate literature and a proposal for a criterion-based, quantitative, multidimensional hierarchical levels of evidence schema for evaluating the status of biomarkers as surrogate endpoints. Stat Methods Med Res 17:303–340. https://doi.org/10.1177/0962280207082719
Le Goff A, Holzinger M, Cosnier S (2011) Enzymatic biosensors based on SWCNT-conducting polymer electrodes. Analyst 136:1279–1287. https://doi.org/10.1039/c0an00904k
Lerner MB, D’Souza J, Pazina T et al (2012) Hybrids of a genetically engineered antibody and a carbon nanotube transistor for detection of prostate cancer biomarkers. ACS Nano 6:5143–5149. https://doi.org/10.1021/nn300819s
Lewis JM, Heineck DP, Heller MJ (2015) Detecting cancer biomarkers in blood: challenges for new molecular diagnostic and point-of-care tests using cell-free nucleic acids. Expert Rev Mol Diagn 15:1187–1200. https://doi.org/10.1586/14737159.2015.1069709
Li H, Cao Z, Zhang Y et al (2011a) Simultaneous detection of two lung cancer biomarkers using dual-color fluorescence quantum dots. Analyst 136:1399–1405. https://doi.org/10.1039/c0an00704h
Li H, Wei Q, Wang G et al (2011b) Sensitive electrochemical immunosensor for cancer biomarker with signal enhancement based on nitrodopamine-functionalized iron oxide nanoparticles. Biosens Bioelectron 26:3044–3049. https://doi.org/10.1016/j.bios.2010.12.011
Li X, Tan J, Yu J et al (2014) Use of a porous silicon-gold plasmonic nanostructure to enhance serum peptide signals in MALDI-TOF analysis. Anal Chim Acta 849:27–35. https://doi.org/10.1016/j.aca.2014.08.028
Lin D, Pan J, Huang H et al (2014) Label-free blood plasma test based on surface-enhanced Raman scattering for tumor stages detection in nasopharyngeal cancer. Sci Rep 4:1–8. https://doi.org/10.1038/srep04751
Lin WY, Wang Y, Wang S, Tseng HR (2009) Integrated microfluidic reactors. Nano Today 4:470–481. https://doi.org/10.1016/j.nantod.2009.10.007
Liu D, Huang X, Wang Z et al (2013) Gold nanoparticle-based activatable probe for sensing ultralow levels of prostate-specific antigen. ACS Nano 7:5568–5576. https://doi.org/10.1021/nn401837q
Lu N, Gao A, Dai P et al (2015) Ultrasensitive detection of dual cancer biomarkers with integrated CMOS-compatible nanowire arrays. Anal Chem 87:11203–11208. https://doi.org/10.1021/acs.analchem.5b01729
Ma H, Li X, Yan T et al (2016) Electrochemiluminescent immunosensing of prostate-specific antigen based on silver nanoparticles-doped Pb (II) metal-organic framework. Biosens Bioelectron 79:379–385. https://doi.org/10.1016/j.bios.2015.12.080
Malhotra R, Patel V, Vaqué JP et al (2010) Ultrasensitive electrochemical immunosensor for oral cancer biomarker IL-6 using carbon nanotube forest electrodes and multilabel amplification. Anal Chem 82:3118–3123. https://doi.org/10.1021/ac902802b
Martínez-Rivas A, Chinestra P, Favre G et al (2010) Detection of label-free cancer biomarkers using nickel nanoislands and quartz crystal microbalance. Int J Nanomedicine 5:661–668. https://doi.org/10.2147/IJN.S12188
Medintz IL, Uyeda HT, Goldman ER, Mattoussi H (2005) Quantum dot bioconjugates for imaging, labelling and sensing. Nat Mater 4:435–446. https://doi.org/10.1038/nmat1390
Mehra R, Tomlins SA, Yu J et al (2008) Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer. Cancer Res 68:3584–3590. https://doi.org/10.1158/0008-5472.CAN-07-6154
Micheel CM, Nass SJ, Omenn GS (2012) Evolution of translational omics. The National Academies Press, Washington, DC
Misra R, Acharya S, Sahoo SK (2010) Cancer nanotechnology: application of nanotechnology in cancer therapy. Drug Discov Today 15:842–850. https://doi.org/10.1016/j.drudis.2010.08.006
Myung N, Ding Z, Bard AJ (2002) Electrogenerated chemiluminescence of CdSe nanocrystals. Nano Lett 2:1315–1319. https://doi.org/10.1021/nl0257824
Nie S, Emory Steven R (1997) Probing single molecules and single nanoparticles by surface-enhanced Raman scattering. Science 275:1102–1106. https://doi.org/10.1126/sciadv.abe4553
Nizioł J, Ossoliński K, Ossoliński T et al (2016) Surface-transfer mass spectrometry imaging of renal tissue on gold nanoparticle enhanced target. Anal Chem 88:7365–7371. https://doi.org/10.1021/acs.analchem.6b01859
Paik S, Shak S, Tang G, Kim C (2004) A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 351:2817–2826. https://doi.org/10.1080/14733400500093379
Pantarotto D, Singh R, McCarthy D et al (2004) Functionalized carbon nanotubes for plasmid DNA gene delivery. Angew Chemie Int Ed Engl 43:5242–5246. https://doi.org/10.1002/anie.200460437
Patel S, Ahmed S (2015) Emerging field of metabolomics: big promise for cancer biomarker identification and drug discovery. J Pharm Biomed Anal 107:63–74. https://doi.org/10.1016/j.jpba.2014.12.020
Patil SJ, Zajac A, Zhukov T, Bhansali S (2008) Ultrasensitive electrochemical detection of cytokeratin-7, using Au nanowires based biosensor. Sensors Actuators B Chem 129:859–865. https://doi.org/10.1016/j.snb.2007.09.080
Piccart-Gebhart MJ, Procter M, Leyland-Jones B et al (2005) Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 353:1659–1672
Qiao Z, Perestrelo R, Reyes-Gallardo EM et al (2015) Octadecyl functionalized core-shell magnetic silica nanoparticle as a powerful nanocomposite sorbent to extract urinary volatile organic metabolites. J Chromatogr A 1393:18–25. https://doi.org/10.1016/j.chroma.2015.03.026
Qin W, Wang K, Xiao K et al (2017) Carcinoembryonic antigen detection with “Handing”-controlled fluorescence spectroscopy using a color matrix for point-of-care applications. Biosens Bioelectron 90:508–515. https://doi.org/10.1016/j.bios.2016.10.052
Ramesh BS, Giorgakis E, Lopez-Davila V et al (2016) Detection of cell surface calreticulin as a potential cancer biomarker using near-infrared emitting gold nanoclusters. Nanotechnology 27:285101. https://doi.org/10.1088/0957-4484/27/28/285101
Ranzoni A, Sabatte G, Van Ijzendoorn LJ, Prins MWJ (2012) One-step homogeneous magnetic nanoparticle immunoassay for biomarker detection directly in blood plasma. ACS Nano 6:3134–3141. https://doi.org/10.1021/nn204913f
Raza MU, Peri SSS, Ma LC et al (2018) Self-induced back action actuated nanopore electrophoresis (SANE). Nanotechnology 29(43):435501. https://doi.org/10.1088/1361-6528/aad7d1
Romond EH, Perez EA, Bryant J et al (2005) Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 353:1673–1684. https://doi.org/10.1056/nejmoa052122
Rusling JF, Sotzing G, Papadimitrakopoulosa F (2009) Designing nanomaterial-enhanced electrochemical immunosensors for cancer biomarker proteins. Bioelectrochemistry 76:189–194. https://doi.org/10.1016/j.bioelechem.2009.03.011
Schuerle S, Dudani JS, Christiansen MG et al (2016) Magnetically actuated protease sensors for in vivo tumor profiling. Nano Lett 16:6303–6310. https://doi.org/10.1021/acs.nanolett.6b02670
Schwaederle M, Chattopadhyay R, Kato S et al (2017) Genomic alterations in circulating tumor DNA from diverse cancer patients identified by next-generation sequencing. Cancer Res 77:5419–5427. https://doi.org/10.1158/0008-5472.CAN-17-0885
Sekhar PK, Ramgir NS, Joshi RK, Bhansali S (2008) Selective growth of silica nanowires using an Au catalyst for optical recognition of interleukin-10. Nanotechnology 19. https://doi.org/10.1088/0957-4484/19/24/245502
Sengupta S, Eavarone D, Capila I et al (2005) Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. Nature 436:568–572. https://doi.org/10.1038/nature03794
Shalev G, Landman G, Amit I et al (2013) Specific and label-free femtomolar biomarker detection with an electrostatically formed nanowire biosensor. NPG Asia Mater 5:1–7. https://doi.org/10.1038/am.2012.75
Sharifi M, Avadi MR, Attar F et al (2019) Cancer diagnosis using nanomaterials based electrochemical nanobiosensors. Biosens Bioelectron 126:773–784. https://doi.org/10.1016/j.bios.2018.11.026
Shehada N, Cancilla JC, Torrecilla JS et al (2016) Silicon nanowire sensors enable diagnosis of patients via exhaled breath. ACS Nano 10:7047–7057. https://doi.org/10.1021/acsnano.6b03127
Shen J, Zhou Y, Fu F et al (2015) Immunochromatographic assay for quantitative and sensitive detection of hepatitis B virus surface antigen using highly luminescent quantum dot-beads. Talanta 142:145–149. https://doi.org/10.1016/j.talanta.2015.04.058
Singh RD, Shandilya R, Bhargava A et al (2018) Quantum dot based nano-biosensors for detection of circulating cell free miRNAs in lung carcinogenesis: From biology to clinical translation. Front Genet 9:1–23. https://doi.org/10.3389/fgene.2018.00616
Slamon DJ, Leyland-Jones B, Shak S, Fuchs H (2001) Use of chemotherapy plus a monoclonal antibody against her2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344:783–792
Tan A, Yildirimer L, Rajadas J et al (2011) Quantum dots and carbon nanotubes in oncology: a review on emerging theranostic applications in nanomedicine. Nanomedicine 6:1101–1114. https://doi.org/10.2217/nnm.11.64
Tan SJ, Yeo T, Sukhatme SA et al (2017) Personalized treatment through detection and monitoring of genetic aberrations in single circulating tumor cells. Adv Exp Med Biol 994:255–273. https://doi.org/10.1007/978-3-319-55947-6_14
Tian B, Cohen-Karni T, Qing Q et al (2010) Three-dimensional, flexible nanoscale field-effect transistors as localized bioprobes. Science 329:830–834. https://doi.org/10.1126/science.1192033
Tîlmaciu CM, Morris MC (2015) Carbon nanotube biosensors. Front Chem 3:1–21. https://doi.org/10.3389/fchem.2015.00059
Tong R, Coyle VJ, Tang L et al (2010) Polylactide nanoparticles containing stably incorporated cyanine dyes for in vitro and in vivo imaging applications. Microsc Res Tech 73:901–909. https://doi.org/10.1002/jemt.20824
Torres A, Alshalalfa M, Tomlins SA et al (2017) Comprehensive determination of prostate tumor ETS gene status in clinical samples using the CLIA decipher assay. J Mol Diagn 19:475–484. https://doi.org/10.1016/j.jmoldx.2017.01.007
Tot T (2002) Cytokeratins 20 and 7 as biomarkers. Eur J Cancer 38:758–763. https://doi.org/10.1016/s0959-8049(02)00008-4
Uludaǧ Y, Tothill IE (2010) Development of a sensitive detection method of cancer biomarkers in human serum (75%) using a quartz crystal microbalance sensor and nanoparticles amplification system. Talanta 82:277–282. https://doi.org/10.1016/j.talanta.2010.04.034
Viswambari Devi R, Doble M, Verma RS (2015) Nanomaterials for early detection of cancer biomarker with special emphasis on gold nanoparticles in immunoassays/sensors. Biosens Bioelectron 68:688–698. https://doi.org/10.1016/j.bios.2015.01.066
Vita M, Skansen P, Hassan M, Abdel-Rehim M (2005) Development and validation of a liquid chromatography and tandem mass spectrometry method for determination of roscovitine in plasma and urine samples utilizing on-line sample preparation. J Chromatogr B Anal Technol Biomed Life Sci 817:303–307. https://doi.org/10.1016/j.jchromb.2004.12.022
Wang HN, Vo-Dinh T (2009) Multiplex detection of breast cancer biomarkers using plasmonic molecular sentinel nanoprobes. Nanotechnology 20. https://doi.org/10.1088/0957-4484/20/6/065101
Wang YW, Doerksen JD, Kang S et al (2016) Multiplexed molecular imaging of fresh tissue surfaces enabled by convection-enhanced topical staining with SERS-coded nanoparticles. Small 12:5612–5621. https://doi.org/10.1002/smll.201601829
Weiss PS (2010) Nanoscience and nanotechnology: present and future. ACS Nano 4:1771–1772. https://doi.org/10.1021/nn100710n
Xie Y, Zhi X, Su H et al (2015) A novel electrochemical microfluidic chip combined with multiple biomarkers for early diagnosis of gastric cancer. Nanoscale Res Lett 10:1–9. https://doi.org/10.1186/s11671-015-1153-3
Xu F, Wei L, Chen Z, Min W (2013) Frustrated FRET for high-contrast high-resolution two-photon imaging. Opt Express 21(12):14097. https://doi.org/10.1364/OE.21.014097
Xu S, Dong B, Zhou D et al (2016) Paper-based upconversion fluorescence resonance energy transfer biosensor for sensitive detection of multiple cancer biomarkers. Sci Rep 6:1–9. https://doi.org/10.1038/srep23406
Xu Y, Jang K, Yamashita T et al (2012) Microchip-based cellular biochemical systems for practical applications and fundamental research: from microfluidics to nanofluidics. Anal Bioanal Chem 402:99–107. https://doi.org/10.1007/s00216-011-5296-5
Ye F, Zhao Y, El-Sayed R et al (2018) Advances in nanotechnology for cancer biomarkers. Nano Today 18:103–123. https://doi.org/10.1016/j.nantod.2017.12.008
Yin PT, Shah S, Chhowalla M, Lee KB (2015) Design, synthesis, and characterization of graphene-nanoparticle hybrid materials for bioapplications. Chem Rev 115:2483–2531. https://doi.org/10.1021/cr500537t
Yoo M, Yeo WS (2016) Determining the ratio of two types of prostate specific antigens with biochips and gold nanoparticles for accurate prostate cancer diagnosis. Anal Sci 32:1117–1121. https://doi.org/10.2116/analsci.32.1117
Yu X, Munge B, Patel V et al (2006) Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers. J Am Chem Soc 128:11199–11205. https://doi.org/10.1021/ja062117e
Zeineldin R (2013) Nanotechnology for cancer screening and diagnosis. Woodhead Publishing Limited, Sawston
Zhang J, Li C, Zhi X et al (2016a) Hairpin DNA-templated silver nanoclusters as novel beacons in strand displacement amplification for microRNA detection. Anal Chem 88:1294–1302. https://doi.org/10.1021/acs.analchem.5b03729
Zhang L, Lv D, Su W et al (2013) Detection of cancer biomarkers with nanotechnology. Am J Biochem Biotechnol 9:71–89. https://doi.org/10.3844/ajbbsp.2013.71.89
Zhang X, Chen B, He M et al (2016b) Boronic acid recognition based-gold nanoparticle-labeling strategy for the assay of sialic acid expression on cancer cell surface by inductively coupled plasma mass spectrometry. Analyst 141:1286–1293. https://doi.org/10.1039/c5an02402a
Zhang Y, Chen B, He M et al (2014) Immunomagnetic separation combined with inductively coupled plasma mass spectrometry for the detection of tumor cells using gold nanoparticle labeling. Anal Chem 86:8082–8089. https://doi.org/10.1021/ac500964s
Zhang Y, Li M, Gao X et al (2019) Nanotechnology in cancer diagnosis: progress, challenges and opportunities. J Hematol Oncol 12:1–13. https://doi.org/10.1186/s13045-019-0833-3
Zheng T, Pierre-Pierre N, Yan X et al (2015) Gold nanoparticle-enabled blood test for early stage cancer detection and risk assessment. ACS Appl Mater Interfaces 7:6819–6827. https://doi.org/10.1021/acsami.5b00371
Zhou WH, Zhu CL, Lu CH et al (2009) Amplified detection of protein cancer biomarkers using DNAzyme functionalized nanoprobes. Chem Commun:6845–6847. https://doi.org/10.1039/b916217h
Zhu D, Yang RX, Tang YP et al (2016) Robust nanoplasmonic substrates for aptamer macroarrays with single-step detection of PDGF-BB. Biosens Bioelectron 85:429–436. https://doi.org/10.1016/j.bios.2016.05.039
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Muhaymin, A., Awan, U.A., Haider, A., Naeem, M. (2022). Nanotechnology for Cancer Biomarkers. In: Shehzad, A. (eds) Cancer Biomarkers in Diagnosis and Therapeutics. Springer, Singapore. https://doi.org/10.1007/978-981-16-5759-7_12
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