Skip to main content

Advertisement

SpringerLink
Log in

Distribution of plasma fatty acids is associated with response to chemotherapy in non-Hodgkin’s lymphoma patients

  • Original Paper
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

Our recent data have linked plasma phospholipid fatty acid (FA) profile in patients with non-Hodgkin’s lymphoma (NHL) with the clinical stage and aggressiveness of the disease. Thus, we proposed that plasma FA status in these patients may influence the effect of chemotherapy. The aim of this work was to assess FA status in NHL patients undergoing chemotherapy in relation to their response to therapy. We analyzed plasma FA profile in 47 newly diagnosed NHL patients before chemotherapy, after 3 cycles and after the end of the planned chemotherapy. Patients were treated according to the hospital protocol: 28 patients with cyclophosphamide, doxorubicin, vincristine and prednisone, 7 with other anthracycline-containing regimens, 4 patients with cyclophosphamide, vincristine and prednisone and 8 with fludarabine-based regimens. Rituximab was added in 22 patients. Ten patients who did not receive all planned chemotherapy due to death or toxicity (non-completers) had significantly lower (p < 0.05) baseline proportion of palmitoleic, linoleic, eicosapentaenoic and docosahexaenoic acid, as well as n-3 and n-6 FA, than the patients who completed chemotherapy (completers). Furthermore, the completers were divided according to the response to chemotherapy to complete remission (CR), stable disease and progressive disease (PD). Proportion of palmitic acid after the end of chemotherapy was the highest in the PD group, while stearic acid showed the opposite trend. Palmitoleic acid and all n-3 FA (18:3, 20:5, 22:5 and 22:6) were the highest in the patients in remission and the lowest in PD (p < 0.001). Linoleic acid decreased and arachidonic acid increased from the CR to the PD group (p < 0.001). These results suggest that aberrations in plasma FA may influence response to chemotherapy in patients with NHL.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Cvetkovic Z, Cvetkovic B, Petrovic M, Ranic M, Debeljak-Martarcic J, Vucic V, et al. Lipid profile as a prognostic factor in cancer patients. J BUON. 2009;14(3):501–6.

    CAS  PubMed  Google Scholar 

  2. Murphy RA, Wilke MS, Perrine M, Pawlowicz M, Mourtzakis M, Lieffers JR, et al. Loss of adipose tissue and plasma phospholipids: relationship to survival in advanced cancer patients. Clin Nutr. 2010;29(4):482–7.

    Article  CAS  PubMed  Google Scholar 

  3. Agatha G, Hafer R, Zintl F. Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia. Cancer Lett. 2001;173(2):139–44.

    Article  CAS  PubMed  Google Scholar 

  4. McClinton S, Moffat LE, Horrobin DF, Manku MS. Abnormalities of essential fatty acid distribution in the plasma phospholipids of patients with bladder cancer. Br J Cancer. 1991;63(2):314–6.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Murphy RA, Bureyko TF, Mourtzakis M, Chu QS, Clandinin MT, Reiman T, et al. Aberrations in plasma phospholipid fatty acids in lung cancer patients. Lipids. 2012;47(4):363–9.

    Article  CAS  PubMed  Google Scholar 

  6. Zuijdgeest-van Leeuwen SD, van der Heijden MS, Rietveld T, van den Berg JW, Tilanus HW, Burgers JA, et al. Fatty acid composition of plasma lipids in patients with pancreatic, lung and oesophageal cancer in comparison with healthy subjects. Clin Nutr. 2002;21(3):225–30.

    Article  CAS  PubMed  Google Scholar 

  7. Lisboa AQ, Rezende M, Muniz-Junqueira MI, Ito MK. Altered plasma phospholipid fatty acids and nutritional status in patients with uterine cervical cancer. Clin Nutr. 2008;27(3):371–7.

    Article  CAS  PubMed  Google Scholar 

  8. Cvetkovic Z, Vucic V, Cvetkovic B, Petrovic M, Ristic-Medic D, Tepsic J, et al. Abnormal fatty acid distribution of the serum phospholipids of patients with non-Hodgkin lymphoma. Ann Hematol. 2010;89(8):775–82.

    Article  CAS  PubMed  Google Scholar 

  9. MacDonald N, Easson AM, Mazurak VC, Dunn GP, Baracos VE. Understanding and managing cancer cachexia. J Am Coll Surg. 2003;197(1):143–61.

    Article  PubMed  Google Scholar 

  10. Marra CA, de Alaniz MJ, Brenner RR. Modulation of delta 6 and delta 5 rat liver microsomal desaturase activities by dexamethasone-induced factor. Biochim Biophys Acta. 1986;879(3):388–93.

    Article  CAS  PubMed  Google Scholar 

  11. Pratt VC, Watanabe S, Bruera E, Mackey J, Clandinin MT, Baracos VE, et al. Plasma and neutrophil fatty acid composition in advanced cancer patients and response to fish oil supplementation. Br J Cancer. 2002;87(12):1370–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Purdue MP, Bassani DG, Klar NS, Sloan M, Kreiger N. Dietary factors and risk of non-Hodgkin lymphoma by histologic subtype: a case-control analysis. Cancer Epidemiol Biomarkers Prev. 2004;13(10):1665–76.

    CAS  PubMed  Google Scholar 

  13. Harris NL, Stein H, Coupland SE, Hummel M, Favera RD, Pasqualucci L, et al. New approaches to lymphoma diagnosis. Hematology Am Soc Hematol Educ Program. 2001;2001(1):194–220.

    Google Scholar 

  14. Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M. Report of the committee on Hodgkin’s disease staging classification. Cancer Res. 1971;31(11):1860–1.

    CAS  PubMed  Google Scholar 

  15. WHO. Obesity: preventing and managing the global epidemic. Geneva: World Health Organization; 2000.

  16. Zilversmit DB, Davis AK. Microdetermination of plasma phospholipids by trichloroacetic acid precipitation. J Lab Clin Med. 1950;35(1):155–60.

    CAS  PubMed  Google Scholar 

  17. Tepsic J, Vucic V, Arsic A, Blazencic-Mladenovic V, Mazic S, Glibetic M. Plasma and erythrocyte phospholipid fatty acid profile in professional basketball and football players. Eur J Appl Physiol. 2009;107(3):359–65.

    Article  CAS  PubMed  Google Scholar 

  18. Arsic A, Vucic V, Tepsic J, Mazic S, Djelic M, Glibetic M. Altered plasma and erythrocyte phospholipid fatty acid profile in elite female water polo and football players. Appl Physiol Nutr Metab. 2012;37(1):40–7.

    Article  CAS  PubMed  Google Scholar 

  19. Zhang J, Zhang L, Ye X, Chen L, Gao Y, Kang JX, et al. Characteristics of fatty acid distribution is associated with colorectal cancer prognosis. Prostaglandins Leukot Essent Fatty Acids. 2013;88(5):355–60.

    Google Scholar 

  20. Pandey M, Khatri AK, Dubey SS, Gautam A, Shukla VK. Erythrocyte membrane fatty acid profile in patients with primary carcinoma of the gallbladder. J Surg Oncol. 1995;59(1):31–4.

    Article  CAS  PubMed  Google Scholar 

  21. Evans LM, Cowey SL, Siegal GP, Hardy RW. Stearate preferentially induces apoptosis in human breast cancer cells. Nutr Cancer. 2009;61(5):746–53.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. de Alaniz MJ, Marra CA. Role of delta 9 desaturase activity in the maintenance of high levels of monoenoic fatty acids in hepatoma cultured cells. Mol Cell Biochem. 1994;137(1):85–90.

    Article  PubMed  Google Scholar 

  23. Marzo I, Martinez-Lorenzo MJ, Anel A, Desportes P, Alava MA, Naval J, et al. Biosynthesis of unsaturated fatty acids in the main cell lineages of human leukemia and lymphoma. Biochim Biophys Acta. 1995;1257(2):140–8.

    Article  PubMed  Google Scholar 

  24. Pala V, Krogh V, Muti P, Chajes V, Riboli E, Micheli A, et al. Erythrocyte membrane fatty acids and subsequent breast cancer: a prospective Italian study. J Natl Cancer Inst. 2001;93(14):1088–95.

    Article  CAS  PubMed  Google Scholar 

  25. Fernandez E, Chatenoud L, La Vecchia C, Negri E, Franceschi S. Fish consumption and cancer risk. Am J Clin Nutr. 1999;70(1):85–90.

    CAS  PubMed  Google Scholar 

  26. Polesel J, Talamini R, Montella M, Parpinel M, Dal Maso L, Crispo A, et al. Linoleic acid, vitamin D and other nutrient intakes in the risk of non-Hodgkin lymphoma: an Italian case-control study. Ann Oncol. 2006;17(4):713–8.

    Article  CAS  PubMed  Google Scholar 

  27. Grunfeld C, Feingold KR. Regulation of lipid metabolism by cytokines during host defense. Nutrition. 1996;12(1 Suppl):S24–6.

    CAS  PubMed  Google Scholar 

  28. Spencer L, Mann C, Metcalfe M, Webb M, Pollard C, Spencer D, et al. The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential. Eur J Cancer. 2009;45(12):2077–86.

    Article  CAS  PubMed  Google Scholar 

  29. Simopoulos AP. Importance of the ratio of omega-6/omega-3 essential fatty acids: evolutionary aspects. World Rev Nutr Diet. 2003;92:1–22.

    Article  CAS  PubMed  Google Scholar 

  30. Tepsic J, Vucic V, Arsic A, Mazic S, Djelic M, Glibetic M. Unfavourable plasma and erythrocyte phospholipid fatty acid profile in elite amateur boxers. Eur J Sport Sci. 2013;13(4):414–21.

    Article  PubMed  Google Scholar 

  31. Xia SH, Wang J, Kang JX. Decreased n-6/n-3 fatty acid ratio reduces the invasive potential of human lung cancer cells by downregulation of cell adhesion/invasion-related genes. Carcinogenesis. 2005;26(4):779–84.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the Project III 41030 financed by the Ministry of Education, Science and Technological Development of the Republic of Serbia.

Conflict of interest

The authors declared no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Hematology, Clinical Hospital Center Zemun, Vukova 9, 11080, Belgrade, Serbia

    Zorica Cvetković

  2. Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Tadeusa Koscuska 1, 11129, Belgrade, Serbia

    Vesna Vučić, Ivana Karadžić, Marija Ranić & Marija Glibetić

  3. Department of Urology, Clinical Hospital Center Zemun, Vukova 9, 11080, Belgrade, Serbia

    Bora Cvetković

Authors
  1. Zorica Cvetković
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vesna Vučić
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bora Cvetković
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ivana Karadžić
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Marija Ranić
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Marija Glibetić
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Vesna Vučić.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cvetković, Z., Vučić, V., Cvetković, B. et al. Distribution of plasma fatty acids is associated with response to chemotherapy in non-Hodgkin’s lymphoma patients. Med Oncol 30, 741 (2013). https://doi.org/10.1007/s12032-013-0741-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12032-013-0741-2

Keywords

Search

Navigation