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Association of polymorphisms in FLT3, EGFR, ALOX5, and NEIL3 with glioblastoma in the Han Chinese population

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Abstract

Glioblastoma (GBM) is the highest-grade glioma in astrocytoma. Patients often have poor prognosis due to therapeutic resistance and tumor recurrence. Identification of the genetic factors of GBM could be important contribution to early prevention of this disease. We genotyped 17 tag single-nucleotide polymorphisms (tSNPs) from nine genes in this study, including 72 cases and 302 controls. SNP genotyping was conducted using Sequenom MassARRAY RS1000. Statistical analysis of the association between tSNPs and GBM was performed using the χ 2 test and SNPStats software. The rs3829382 in FLT3 was associated with increased odds of developing GBM using the χ 2 test. When we analyzed tSNPs under different inheritance models, we found rs9642393 in EGFR increased odds of developing GBM in the dominant model. After stratification by gender, we found that rs12645561 in NEIL3 and rs2291427 in ALOX5 were associated with developing GBM. Polymorphisms within FLT3, EGFR, NEIL3, and ALOX5 may contribute to the occurrence of GBM in the Han Chinese population. However, the functional significance of these polymorphisms needs further investigation.

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Acknowledgments

This work was supported by China Postdoctoral Science Foundation funded Projects (No. 2012M521798). The authors declare that they have no competing interests. We thanked all the patients and individuals for their participation in this study.

Conflict of interest

The authors declare that they have no conflict of interests.

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Authors and Affiliations

  1. Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Tibet University for Nationalities, #6 East Wenhui Road, Xianyang, 712082, Shaanxi, China

    Tian-Bo Jin, Mutu Jiri, Xu-Gang Shi, Dong-Ya Yuan & Long-Li Kang

  2. National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi’an, 710069, Shaanxi, China

    Tian-Bo Jin, Xiao-Lan Li & Hua Yang

  3. Medical Examination Center of Tangdu Hospital, The Fourth Military Medical University, No. 569 Xinsi Road, Xi’an, 710038, Shaanxi, China

    Shan-Qu Li

Authors
  1. Tian-Bo Jin
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  2. Xiao-Lan Li
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  3. Hua Yang
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  4. Mutu Jiri
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  5. Xu-Gang Shi
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  6. Dong-Ya Yuan
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  7. Long-Li Kang
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  8. Shan-Qu Li
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Corresponding authors

Correspondence to Long-Li Kang or Shan-Qu Li.

Additional information

Tian-Bo Jin and Xiao-Lan Li are joint first authors.

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Jin, TB., Li, XL., Yang, H. et al. Association of polymorphisms in FLT3, EGFR, ALOX5, and NEIL3 with glioblastoma in the Han Chinese population. Med Oncol 30, 718 (2013). https://doi.org/10.1007/s12032-013-0718-1

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  • DOI: https://doi.org/10.1007/s12032-013-0718-1

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