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Emerging Role of Non-coding RNAs in Autism Spectrum Disorder

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Abstract

Autism spectrum disorders (ASD) embrace a diverse set of neurodevelopmental diseases with a multifaceted genetic basis. Non-coding RNAs (ncRNAs) are among putative loci with critical participation in the development of ASD. Expression of some lncRNAs, namely RP11-466P24.2, SYP-AS1, STXBP5-AS1, and IFNG-AS1 has been decreased in ASD, while AK128569, CTD-2516F10.2, MSNP1AS, RPS10P2-AS1, LINC00693, LINC00689, NEAT1, TUG1, and Shank2‐AS lncRNAs have been over-expressed in ASD. Expression of several miRNAs which are implicated in the immunological developmental, immune responses, and protein synthesis as well as those participating in the regulation of PI3K/Akt/mTOR and EGFR signaling pathways is dysregulated in the context of ASD. In the present article, we describe investigations which appraised the role of lncRNAs, miRNAs, and circRNAs in the pathobiology of ASD.

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Abbreviations

ASD:

Autism spectrum disorders (ASD)

ncRNAs:

Non-coding RNAs

miRNAs:

MicroRNAs

circRNAs:

Circular RNAs

NATs:

Natural antisense transcripts

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Authors and Affiliations

  1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Soudeh Ghafouri-Fard

  2. Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland

    Rezvan Noroozi

  3. Psychiatric Clinics, Center for Affective, Stress and Sleep Disorders, University of Basel, Basel, Switzerland

    Serge Brand

  4. Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq

    Bashdar Mahmud Hussen

  5. Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Reyhane Eghtedarian

  6. Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Taheri

  7. Institute of Human Genetics, Jena University Hospital, 07740, Jena, Germany

    Mohammad Taheri

  8. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Kaveh Ebrahimzadeh

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  1. Soudeh Ghafouri-Fard
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  2. Rezvan Noroozi
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  3. Serge Brand
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  4. Bashdar Mahmud Hussen
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  6. Mohammad Taheri
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Contributions

SGF wrote the draft and revised it. MT designed and supervised the study. SB and KE edited the final version and collected the data. RN, BMH, and RE collected the data and designed the figure and tables. All the authors read and approved the submitted version.

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Correspondence to Mohammad Taheri or Kaveh Ebrahimzadeh.

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Ghafouri-Fard, S., Noroozi, R., Brand, S. et al. Emerging Role of Non-coding RNAs in Autism Spectrum Disorder. J Mol Neurosci 72, 201–216 (2022). https://doi.org/10.1007/s12031-021-01934-3

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